Vitamin B1 - B6 - B12 Mekophar drugs for treatment of B vitamins (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Vitamin B1, Vitamin B6, Vitamin B12

Ingredient

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Composition information	Content
Vitamin B1	125mg
Vitamin B6	125mg
Vitamin B12	125mcg

Uses

Indications

Vitamin B1-B6-B12 drugs are indicated in the following cases:

Treatment of vitamin B vitamins due to nutrition such as weakness , anorexia, anemia , nursing period.

neurological disorders caused by isoniazid.

neuropathic disorders, multiple neuritis due to chronic alcoholism.

Red blood cell anemia.

Pharmacokology

Thiamin, Pyridoxin, Cyanocobalamin are vitamins of group B, when entering the body:

Thiamin combined with Adenosin Triphosphate (ATP) in the liver, kidneys, leukocytes to form a thiamin diphosphate form is coenzyme carbohydrate metabolism, which is responsible for carboxyl reduction of alpha-cetoacids such as pyruvat and alpha-cetoglutarat and in using pentose in the Hexose cycle Monophosphate. These two substances act as coenzymes in metabolism of protein, glucid and | lipid. Pyridoxin participates in the synthesis of gamma-aminobutyric acid (GABA) in the central nervous system and participates in the synthesis of hemoglobin. Hematoma, synthesis of nucleoprotein and myelin.

The rate of thiamin absorption through the gastrointestinal tract decreases when taking the drug during meals, the drug is distributed into most tissues and milk. When absorbing at a minimum of daily need, there are very little or no thiamin excreted through the urine. When absorbed beyond the minimum needs, Thiamin warehouses in saturated tissues, the amount of excreted through the urine in the form of intact thiamin molecules and metabolized form.

pyridoxine is largely reserved in the liver and part of the brain. In red blood cells, pyridoxin transformed into pyridoxal phosphate. In the liver, pyridoxin phosphoryl turned into pyridoxin phosphate and transformed the amines into pyridoxal and pyridoxamin to quickly get phosphorylation. The sale time of pyridoxin is about 15-20 days. In the liver, pyridoxal transforms into 4-pyridoxic acid excreted into urine.

Cyanocobalamin is absorbed in the second half of the ileum. In the bloodstream, Cyanocobalamin attaches to Transcobalamin II is a plasma globulin to be transported to tissues. The peak concentration in plasma is achieved after taking 8 - 12 hours, Cyanocobalamin is metabolized in the liver, the sale time is about 6 days, Cyanocobalamin is eliminated through bile and has a liver - intestinal cycle. Cyanocobalamin exceeds the daily demand that is discharged through urine, mostly in the form of non -metabolic. Cyanocobalamin passes the placenta and distributes into breast milk.

Before taking Vitamin B1 - B6 - B12 Mekophar drugs for treatment of B vitamins (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Dosage: According to the doctor's instructions.

Recommended dose:

Adults:

The shortage of B vitamins, neurological disorders caused by Isoniazid: take 1 tablet/day.

Neurological disorders, multiple neuritis due to chronic alcoholism: take 1 tablet, 2 times/day.

Red blood cell anemia: Take 1 capsule, 3 times/day.

Children: Do not recommend using this preparation for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

How to handle: Actively monitor for timely treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using vitamin B1-B6-B12, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Rare, ADR

The immune system: allergic reactions.

Not determined frequency

Use vitamin B6 dose of 200mg/day and prolonged (over 2 months) can cause severe peripheral neuropathy, progressing from unstable gait and numbness to numbness and clumsy hands. This condition can recover when stopping the drug, although there is still more or less sequelae.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin B1-B6-B12 drug is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

malignant u: Because vitamin B12 increases the tissue with high growth rate, there is a risk of progression

Be cautious when using

avoid simultaneous use with alcohol.

Children should be used under adult supervision.

After a long time of using vitamin B6 at a dose of 200mg/day, it may have been seen manifestation of neurotoxicity (such as severe peripheral neuropathy and severe sensory neurological disease). Using a dose of 200mg per day, lasting over 30 days can cause a dependence of vitamin B6.

Preparations containing lactose, cautious when used for patients with rare genetic disorders in galactose tolerance, lactase lactase deficiency or glucose-galactose absorption disorders.

Preparations containing erythrosin, a few studies show that erythrosin causes mouse thyroid tumors and affects the function of the thyroid gland, but there is no firm conclusion about these effects.

The ability to drive and operate machinery

When using vitamin B6 dose over 200mg/day for a long time can cause neurological disease. Be careful when using with drivers, operators or people doing dangerous jobs that need focus.

Pregnancy

Pregnancy: High doses of vitamin B6 can cause drug dependence syndrome in infants.

Be cautious when used for pregnant women.

breastfeeding period

Precautions when used for breastfeeding women

Interactive drugs, cavalry of drugs

Interaction of drugs:

Isoniazid, penicilamine, oral contraceptives can change the metabolism or bioavailability of vitamin B6.

Vitamin B6 reduces the effect of levodopa, unless combined with dopadecarboxylase inhibitors.

Using vitamin B6 dose of 200mg/day can cause a decrease in 40-50% of the concentration of phenytoin and phenobarbital in the blood in some patients.

aminoglycosides, chloramphenicol, cimetidine reduces the absorption of vitamin B6:

Absorption of vitamin B12 from the gastrointestinal tract may be reduced when used with Neomycin, aminosalicylic acid, anti -receptor drugs H2 and Colchicin.

Serum concentration may be reduced when used simultaneously with oral contraceptives.

chloramphenicol used on the gastrointestinal tract may reduce the effect of vitamin B12 in anemia.

The treatment effect of vitamin B12 may be reduced when used simultaneously with omeprazol. Omeprazol reduces gastric acid, so it reduces the absorption of vitamin B12.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Other drugs

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