Vitamin B12 Kabi 1000mcg medicine for Vitamin B12 deficiency (100 tubes x 1ml)

Dosage form 100 tube box
Specifications Cyanocobalamin

Ingredient

Composition information	Content
Cyanocobalamin	1000mcg

Uses

Indications

Vitamin B12 Kabi indicated in the following cases:

Treatment of vitamin B12 deficiency due to lack of ability to absorb Bioolmer. ATC code: b03ba01.

Vitamin B12 has the effect of hematuria. In the human body, these cobalamin forms coenzymes active are methylcobalamin and 5 - deoxyadenosylcobalamin is essential for cells copied and increased
heads, hematopoietic, nucleoprotein and myelin synthesis.

methylcobalamin is essential for creating methionin and derivatives of s-adenosylmethionin from homocystein.

methylcobalamin is also closely related to folic acid in some important metabolic paths. When vitamin B2 levels are not enough, it will impair the function of some other types of folic acid in the cell.

Hematology abnormalities in patients with vitamin B12 deficiency are due to this process. 5-damoxaadenosylcobalamin is essential for the isomorphic, converting L-methylmalonyl coa into success. Vitamin B2 is essential for all tissues with strong growth speeds such as hematuria, small intestine, uterus.

Lack of vitamin B12 can cause non -recovery damage in the nervous system, myelin is destroyed, have seen nerve cells in the spine and cortex died, causing some neurological symptoms such as abnormalities in the hands, feet, loss of tendon reflexes, confusion, dementia, hallucinations, mental disorders.

These nerve damage can occur without changes in hematopoietic systems. Therefore, Vitamin B12 deficiency can also occur with the elderly dementia or mental signs even without anemia.

The mechanism of nerve damage due to the lack of vitamin B12 is not well known, possibly due to the deficiency of methionine synthetase and methionine is not converted into s-adenosylmethionin.

pharmacokinetics

absorption:

After intramuscularly, Vitamin B12 is absorbed quickly and the peak plasma concentration is achieved after 1 hour.

Distribution:

After absorption, vitamins B12 binds to Transcobalamin I and II and is quickly removed from plasma to distribute priority to the liver parenchyma. The liver is home to 90% of the reserve of vitamin B12, some of the kidney reserves.

Vitamin B12 passes the placenta and is secreted into breast milk.

Vitamin B12 metabolizes in the liver.

The sale time of vitamin B2 is about 6 hours. Vitamin B12 is excreted by the surface and has a liver cycle. Vitamin B, beyond the daily demand is eliminated through urine, are largely in the form of non -metabolic.

Before taking Vitamin B12 Kabi 1000mcg medicine for Vitamin B12 deficiency (100 tubes x 1ml)

How to use

vitamin B12 used by intramuscularly.

Do not get intravenously.

Dosage

attack dose: Use 1000 mcg (1 tube) daily or 3 times per week, intramuscularly. Use 10 mg (10 tubes) during the treatment.

Maintenance dose: 1000 mcg (1 tube) per month, intramuscularly.

Note: Cyanocobalamin injected containing benzyl alcohol preservatives are not used for babies and premature babies because they can be toxic leading to death.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using vitamin B12 Kabi, you may experience unwanted effects (ADR).

Allergic reactions are rare but sometimes very heavy can be deadly after injecting COBALAMIN.

Rare, ADR

Body: Anaphylaxis reaction, fever, headache, dizziness, bronchospasm, mouth-covered vessel. Treatment.

Unwanted effects are usually mild, self -out, except for anaphylactic reaction.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vitamin B12 Kabi is contraindicated in the following cases:

History of allergies to cobalamin.

Be cautious when used

This drug contains sodium, which should be cautious for patients who are having the mode of sodium.

There is no specified diagnosis. Regularly monitor the patient's blood parameters.

Most huge red blood cell anemia is due to vitamin B12 deficiency or folic acid. It is necessary to identify the cause before treatment, do not use folic acid to treat huge red blood cell anemia unknown cause unless combined with vitamin B12, otherwise it will promote neurological damage due to vitamin B12 deficiency.

improper use of the drug can hide the accurate diagnosis.

Patients with malignant anemia need to be treated monthly vitamin B12 for the rest of their lives. If not, it will cause recurrent anemia and increase the risk of insecurity and no damage
to restore spinal cord nerves.

During the initial treatment in malignant anemia patients, strictly controlled potassium potassium for the first 48 hours and supplemented if necessary.

The impact of the drug on the ability to drive and operate machinery

No report.

Used for pregnant and lactating women

Pregnancy: There is no full research on humans. No problem occurs when using vitamin B12 with daily recommended dose.

When used with treatment dose, it is necessary to consider the benefits of the mother and the potential risk for the fetus. This drug should not be used to treat huge red blood cell anemia in pregnant women because this is due to folate.

Breastfeeding period: Vitamin B12 is secreted into breast milk. No problem occurs when used in daily recommended dose. When you have to use vitamin B12 for a mother in the case of pathology, you can still breastfeed.

Medicinal interaction

simultaneously use vitamin B12 with chloramphenicol can reduce the effect of hematuria treatment of vitamin B2 in anemia patients. Need to be closely monitored when using these two drugs.

methotrexate, pyrimethamine and most antibiotics are at risk of affecting bacterial diagnostic tests due to vitamin B12 deficiency.

Cavalry:

can mix vitamin B12 in a solution with vitamin B1, B6, or with fumarat iron, ascorbic acid, folic acid, sulfate or iron fructose and folic acid in some forms of injection.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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