Vitamin B6 100mg/ml Vinphaco injection is treated with vitamin B6 deficiency, Parkinson's toxicity, Parkinson's disease (100 pipes x 1ml)

Dosage form 100 tube box
Specifications Pyridoxin hydrochloride

Ingredient

Thành phần cho 1ml

Composition information	Content
Pyridoxin hydrochloride	25mg

Uses

indications

Vitamin B6 drugs are indicated in the following cases:

Treatment of vitamin B6 deficiency. Isoniazid in tuberculosis treatment. These two substances act as coenzymes in the metabolism of protein, glucid and lipid. Pyridoxin participates in the synthesis of gamma acid - Aminobutyric (GABA) in the central nervous system and participates in Hemoglobulin synthesis.

Daily needs for children are 0.3 - 2 mg, adults about 1.6 - 2 mg and pregnant or lactating mothers are 2.1 - 2.2 mg. It is rare for vitamin B6 deficiency in humans, but it may occur in the case of absorption disorders, congenital metabolic disorders or drug disorders caused by drugs. For patients treated with isoniazid or women who take birth control pills, vitamin B6 needs more daily than usual.

Many drugs such as pyridoxin antagonists: isoniazid, cycloserin, penicilamine, hydralazin and other carbonyl groups can be combined with vitamin B6 and inhibit the Coenzyme function of this vitamin. Pyridoxin is used to treat seizures and/or coma due to isoniazid poisoning. These symptoms are considered to be caused by reduction in gaba concentrations in the central nervous system, perhaps due to Isoniazid inhibits the activity of pyridoxal - 5 - phosphate in the brain. Pyridoxin is also used as a medicine to support other measures in the treatment of acute poisoning caused by Giromitra to treat nervous effects (such as convulsions, coma) of methylhydrazin, hydrolyzed from gyrometrin toxins found in these mushrooms.

Pharmacokinetics

absorption

After injection, pyridoxin is quickly absorbed.

Metabolism

pyridoxin is converted into activity form of pyridoxal phosphate. This substance is kept mainly in the liver and is converted into 4-pyridoxic acid and some other non-active substances.

Elimination

mainly excreted through the kidneys. Pyridoxin also passes the placenta and is present in breast milk.

Before taking Vitamin B6 100mg/ml Vinphaco injection is treated with vitamin B6 deficiency, Parkinson's toxicity, Parkinson's disease (100 pipes x 1ml)

How to use

intravenously or intravenously.

Dosage

Usual dose: 100 - 1000mg/day. Use 15-20 days.

Treatment of convulsions in young children dependent pyridoxin: Taking dose 10 - 100mg intramuscular or intravenously.

Isoniazid poisoning treatment: Take a dose of 1 - 4 g of intravenous injection, then intramuscularly 1 g, every 30 minutes until the dose is out.

Cycloserin overdose: Local dose 25mg/kg, 1/3 intramuscular injection, the rest of the intravenous injection for 3 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? This condition can recover when stopping the drug, although there is still more or less sequelae.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using vitamin B6, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Rare, ADR

Digestive: Nausea and vomiting.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vitamin B6 drugs are contraindicated in cases of hypersensitivity to drugs or any ingredients of the drug.

Be cautious when used

After a long time of using pyridoxin at a dose of 200 mg/day, it may have seen a manifestation of neurotoxicity (such as severe peripheral neuropathy and severe sensory neurological disease).

Taking a dose of 200 mg daily, lasting over 30 days can cause pyridoxin dependence syndrome.

The ability to drive and operate machinery

The drug has little effect on the ability to drive and operate machinery.

Pregnancy

Additional doses on daily needs are not harmful to the fetus, but with high doses that can cause drug dependence syndrome in infants.

The period of breastfeeding

does not affect anything when used according to daily needs. Having used high doses of pyridoxin (600mg/day, divided 3 times) to turn off the milk, although it is usually not effective.

Drug interaction

pyridoxin reduces the effect of levodopa in the treatment of Parkinson's disease; This does not happen with the preparation is a mixture of Levodopa - Carbidopa or Levodopa - Enserazid.

Dosage of 200 mg/day may cause 40 to 50% reduction in phenytoin and phenobarbiton levels in the blood in some patients.

pyridoxin can lighten depression in women who take birth control pills.

Oral contraceptives can increase the demand for pyridoxin.

Storage

In closed packaging, avoiding warm, avoiding light, temperatures below 30 ° C.

Other drugs

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