Vitamin B6 250mg Mekophar drug treatment vitamin B6 (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Pyridoxin HCl

Ingredient

Composition information	Content
Pyridoxin HCl	250mg

Uses

indications

Vitamin B6 250 mg is indicated in the following cases:

Vitamin B6 deficiency treatment.

Anemia genetic iron cells.

Treatment of metabolic disorders: Treatment of oxalic acid hypertrophy in primary urine, primary urine homocysteine, primary urinary cystathionine, or urine with xanthurenic acid.

Pharmacokology

pyridoxine (vitamin B6) is a high -body B vitamin in water, when entering the body, it changes into a pyridoxal phosphate and pyridoxamine phosphate.

These two substances work as coenzymes in metabolism of protein, glucid and lipid. Pyridoxine participates in the synthesis of gamma-aminobutyric acid (GABA) in the central nervous system and participates in Hemoglobin synthesis. Pyridoxine deficiency can lead to iron -cell anemia, peripheral neuritis, seborrheic dermatitis, dry lips.

pharmacokinetics

absorption:

Vitamin B6 is easily absorbed through the gastrointestinal tract, which can be reduced in people with malabsorption syndrome or after gastric cutting. The normal concentration of pyridoxine in plasma is 30–80 ng/ml.

Distribution:

After injection or oral, most of the liver is stored in the liver, partly in the muscle and brain. The whole body of Vitamin B6 is estimated at about 167 mg, in the main forms of vitamin B6 in the blood, pyridoxal and pyridoxal phosphate, high links to proteins. Pyridoxal through placenta and fetal plasma concentrations 5 times more concentrations in the mother's plasma.

Metabolism:

In the liver, pyridoxine phosphoryl turned into pyridoxine phosphate and transformed amine into pyridoxal and pyridoxamine to quickly get phosphorylation. Riboflavin is necessary to convert pyridoxine phosphate into pyridoxal phosphate.

Era:

Semi -selling time of pyridoxine is about 15–20 days. In the liver, pyridoxine transforms into 4-pyridoxic acid excreted into urine. Pyridoxal can be removed by hemolysis.

Before taking Vitamin B6 250mg Mekophar drug treatment vitamin B6 (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Dosage as directed by the doctor.

Recommended dose:

Treatment of vitamin B6 deficiency: Adults take 1–4 tablets/day.

Treatment of genetic iron -cell anemia: 1–2 tablets/day. If after 1–2 months of treatment, the disease does not improve, and another treatment must be considered. If there is a response, pyridoxine can be reduced to 30–50mg/day. It may be required to be treated with this vitamin for a lifetime to prevent anemia in people.

Treatment of metabolic disorders: 1–2 tablets/day. If responded, prolonged treatment for life. Some patients with increased anti -primary oxalia can be treated at lower doses (physiological doses or less than 100 mg/day).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

pyridoxine is usually not toxic. Using pyridoxine lasts for a dose of 10 mg/day is said to be safe, but using pyridoxine for a long time at a larger dose or equal to 200 mg/day can cause neurological diseases. In addition, you may experience unwanted effects (ADR) later.

Central nerve: headache , drowsiness, drowsiness.

Endocrine and metabolism: acidic acidosis, folic acid decreased.

digestion: Nausea, vomiting. liver: AST increases.

Nervousness - Topic: Topic of 200 mg/day and long (over 2 months) can cause severe peripheral nerves, progressing from unstable and numbness to numbness and clumsy hands. This condition can recover when stopping the drug, although there is still more or less sequelae.

Other: allergies.

Instructions on how to handle ADR

Stop using the drug if necessary. Immediately notify the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Vitamin B6 250 mg contraindicated in the following cases:

Hypersensitivity to pyridoxine or any ingredients of the drug.

Used in combination with IEVODOPA.

Be cautious when used

After a long time of using pyridoxine (vitamin B6) larger than or equal to 200 mg/day, showing manifestation of nerve toxicity (severe peripheral neuropathy and severe sensory neurological disease).

The larger dose or 200 mg/day lasts more than 30 days can cause pyridoxine dependence syndrome and cessation syndrome.

Preparations contain lactose monohydrates and white sugar. Caution or should not use this medication for patients with rare genetic disorders in galactose tolerance and fructose, lactase lactase deficiency, glucose -galactose absorption disorders, or sucrase - Isomtase.

Preparations containing castor oil, which can cause stomach pain and diarrhea .

Preparations containing methyl hydroxybenzoate and propyl hydroxybenzoate, which can cause allergic reactions (may be delayed), cautious when used.

The ability to drive and operate machinery

When using vitamin B6 dose over 200 mg/day for a long time can cause neurological disease. Be careful to use with people who perform dangerous jobs and need focus.

Pregnancy

Animal studies do not show any teratogenic effect. In the absence of teratogenic effect in animals, but it is not sure that the drug will cause human defects. So far, human defects have been shown to cause teratogenicity in animals in studies conducted well on both species.

In clinical studies, analysis on a large number of women exposed to drugs during pregnancy does not seem to show any specific effects of malformations or toxic fetuses. However, only epidemiological studies can verify drugs without such risks.

This preparation can be prescribed during pregnancy if necessary.

The period of breastfeeding

There is no sufficient data, avoiding use during breastfeeding.

drug interaction

pyridoxine reduces the effect of levodopa in the treatment of Parkinson's disease; This does not happen with the preparation is a mixture of levodopa - carbidopa or levodopa - benserazide.

Dosage of 200 mg/day may cause 40–50% decrease in the concentration of phenytoin and phenobarbital in the blood in some patients.

Some drugs may increase the demand for pyridoxine such as hydralazine, isoniazid, penicillamine and oral contraceptives. Pyridoxine can gently reduce depression in women who take birth control pills.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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