Vitamin B6 250mg Vidipha treatment for vitamin B6 deficiency (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Vitamin B6

Ingredient

Composition information	Content
Vitamin B6	250mg

Uses

indications

Vitamin B6 250 mg is indicated in the following cases:

Vitamin B6 deficiency treatment. These two substances act as coenzymes in metabolism of protein, glucid and lipid. Pyridoxine participates in the synthesis of gamma-aminobutyric acid (GABA) in the central nervous system and participates in Hemoglobin synthesis.

Daily needs for children are 0.3–2 mg, adults about 1.6–2 mg and pregnant or nursing mothers are 2.1–2.2 mg. It is rare for vitamin B6 deficiency in humans, but it may occur in the case of absorption disorders, congenital metabolic disorders or drug disorders caused by drugs. When there is a shortage due to nutrition, there is less difficult case of a B vitamins, so vitamin supplements in the form of a mixture are more effective than single use.

The best is still improving the diet. Meat, fish, eggs, milk, liver, kidneys, vegetables, fruits are a rich source of natural pyridoxine. Increased body demand and vitamin B6 supplementation may be necessary in the following cases: alcoholism, burns, congestive heart failure, prolonged fever, stomach removal, dialysis, hyperthyroidism, bacterial infections, intestinal diseases (such as diarrhea, bowel inflammation), malabsorption related to liver - knot. For patients treated with isoniazid or women who take birth control pills, vitamin B6 needs more daily than usual.

Pyridoxine deficiency can lead to iron -cell anemia, peripheral neuritis, seborrheic dermatitis, dry lips.

Some metabolic disorders such as xanthurenic acid - urinary, cystathionine - primary primary, increased oxalate - primary (genetic) can respond to high doses of pyridoxine.

Pharmacokinetics

absorption

Pyridoxine is easily absorbed through the gastrointestinal tract, which may be reduced in people with malabsorption syndrome or after gastric cutting. Pyridoxine's normal concentration in plasma is about 30–80 ng/ml.

Distribution

After injection or oral, the drug is mostly reserved in the liver, less than in the muscle and brain. The whole body of Vitamin B6 is estimated at about 167 mg. The main types of vitamin B6 in the blood are pyridoxal and pyridoxal phosphate highly linked to protein.

pyridoxal through the placenta and concentration in fetal plasma is 5 times the concentration of the mother's plasma. Vitamin B6 concentration in breast milk is about 150–204 ng/ml after the mother takes 2.5–5 mg of vitamin B6 daily, vitamin B6 concentration in breast milk on average 130 ng/ml.

Metabolism

In red blood cells, pyridoxine converted into pyridoxal phosphate and pyridoxamine converted into pyridoxamine phosphate. In the liver, pyridoxine phosphoryl turned into pyridoxine phosphate and transformed amine into pyridoxal and pyridoxamine to quickly get phosphorylation. Riboflavin is necessary to convert pyridoxine phosphate into pyridoxal phosphate.

Elimination

Semi -selling time of pyridoxine is about 15-20 days. In the liver, pyridoxal transforms into 4-pyridoxic acid excreted into the urine. In cirrhosis, the rate of degradation may increase. Pyridoxal can be removed by hemolysis.

Before taking Vitamin B6 250mg Vidipha treatment for vitamin B6 deficiency (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Children: Use other cell formats with appropriate content.

Adults: Take pills with a little water, 1-4 capsules each.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Stop using pyridoxine. After stopping pyridoxine, neurological dysplasia gradually improved and long -term monitoring saw a good recovery, can stop the drug for up to 6 months for the sensory nervous system to return to normal.

What to do when forgetting a dose? But if it's almost time for the next dose, only use the following dose. Do not use double dose or add dose to compensate for the dose to forget to drink.

Side Effects

When using Vitamin B6 250 mg, you may experience unwanted effects (ADR).

Using pyridoxine lasts at a dose of 10 mg/day is said to be safe but using pyridoxine for a long time at a dose of 200 mg or more daily can cause neurological disease.

Central nerve: headache, drowsiness, drowsiness.

Endocrine and metabolism: Acid infection, folic acid decreased.

digestive: Nausea and vomiting. liver: AST increases.

Neuros - muscle: Taking a dose of 200 mg/day and long (over 2 months) can cause severe peripheral neuropathy, progressing from unstable appearance and numbness to numbness and clumsy hands. This condition can recover when stopping the drug, although there is still more or less sequelae.

Other: allergic reactions.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin B6 250 mg is contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Be cautious when used

After a long time of using pyridoxine at a dose of 200 mg/day or more daily, showing manifestations of nerve toxicity (such as severe peripheral neuropathy and severe sensory neuropath).

Taking a dose of 200 mg or more every day, lasting over 30 days can cause pyridoxine dependence syndrome and cessation syndrome.

using pyridoxine for a long time with a daily dose of over 10 mg has not been shown to be safe.

Drugs containing excipients can cause abdominal pain and diarrhea.

The drug contains lactose excipients, should not be used for patients with galactose intolerance, lactase deficiency, glucose-galactose absorption disorders.

The ability to drive and operate machinery

Precautions when taking the drug because the drug can cause headaches, drowsiness, drowsiness.

pregnancy

pyridoxine through the placenta and there is evidence of safety when used for pregnant women. Additional dose according to daily needs is not harmful to the fetus.

breastfeeding period

pyridoxine into breast milk. No effect when used according to daily needs. High -dose pyridoxine has been used (600 mg/day, divided into 3 times) to turn off milk, although it is usually ineffective.

Drug interaction

pyridoxine reduces the effect of levodopa in the treatment of Parkinson's disease.

Dosage 200 mg/day may cause a decrease in 40-50% of the concentration of phenytoin and phenobarbital in the blood in some patients.

Pyridoxine can lighten depression in women who take birth control pills.

Oral contraceptives can increase Pyridoxine demand.

Storage

Store in dry places, temperatures not exceeding 30 ° C, avoiding light.

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