Vitamin B.Vitab B12 Danapha prevents and treats calcium and B vitamins (100 tablets) (100 tablets)

Riboflavin (Vitamin B2) is transformed into 2 coenzymes, Flavin Mononucleotid (FMN) and Flavin Adenin Dinucleotid (FDA), which are dynamic coenzymes needed for tissue respiration. Riboflavin is needed for the activation of pyridoxin, the conversion of trytophan into niacin and related to the integrity of red blood cells.

pyridoxin (vitamin B6) exists in three forms: pyridoxal, pyridoxin and pyridoxamin, when entering the body transforms into pyridoxal phosphate and partially into pyridoxamin phosphate. These two substances act as coenzymes in metabolism of protein, glucid, and lipid. Pyridoxin participates in the synthesis of Aminobutyric Gama acid (GABA) in the central nervous system and participates in the synthesis of hemoglobulin.

Nicotinamid (vitamin PP) in the function can be performed after converting to Nicotinamid Adenin Dinucleotid (NAD) or Nicotinamid Adenin Dinucleotid phosphate (NADP). NAD and NADP have a vital role in metabolism, as a coenzyme that catalyzes the redox reaction necessary for cell respiration, glycogen resolution and lipid metabolism. Among these reactions, these coenzymes work as hydrogen transport molecules.

calcium pantothenate (vitamin B5): People need an external pantothenic acid source for intermediate metabolism of carbohydrates, proteins, lipids. Pantothenic acid is the precursor of coenzym A needed for acetylation reaction (Acyl group activation) in the new glucose, releasing energy from carbohydrates, synthesizing and degrading fatty acids, sterol synthesis and steroid hormones, porphyrin, acetylcholin and other compounds. Pantothenic acid is also necessary for the normal function of the epithelium.

vitamin B12 (cyanocobalamin) in the form of coenzym, plays a major role in hematuria.

Dynamic pharmacokinetics

Thiamin (Vitamin B1): The absorption of Thiamin in daily eating through the gastrointestinal tract is due to the positive transportation of Na+. When Thiamin concentration in the gastrointestinal tract, passive diffusion is also important. However, high -dose absorption is limited. In adults, about 1 mg of Thiamin is completely struck every day in tissues and this is the minimum amount of daily need. When absorbed at this level, there are very little or no thiamin excreted through urine in the form of intact thiamin molecules. When thiamin absorption increases further, excretion in the form of unprocessed thiamin will increase.

riboflavin (vitamin B2) is absorbed mainly in the duodenum. Riboflavin metabolites are distributed throughout the tissue in the body and into milk. A small amount of reserves in the liver, spleen, kidney and heart. Riboflavin dissolves in water, excreted through the kidneys and partly through the stool. In people with abdominal fertilizer and artificial dialysis, riboflavin is also eliminated but slower in people with normal kidney function. Riboflavin passes through the placenta and milk.

pyridoxin (vitamin B6) is quickly absorbed through the gastrointestinal tract, except for the case of poorly absorbed syndrome. The drug is mostly reserved in the liver and parts in the muscle and brain. Pyridoxin excreted mainly through the kidneys in the form of metabolism. The amount of introduction if exceeding the daily demand is mostly eliminated in the form of constant.

Nicotinamid absorbs quickly through the gastrointestinal tract after taken and widely distributed into the body tissue. Half of the lifetime of the drug is about 45 minutes. Nicotinamd metabolizes the liver into n-methylnicotinamid, 2-pyridon and 4-pyridon derivatives and also forms nicotnurid. After using nicotinamid at the usual doses, only a small amount of excretion in the urine in the form of constant, but when large doses are used, the amount of excretion in the form of unchanged will increase.

Calcium pantothenate (Vitamin B5) is easy to absorb through the gastrointestinal tract after oral. The normal pantothenate concentration in serum is 100 micrograms/ml or more. Dexpanthanol easily converts into pantothenic acid, which is widely distributed in the body tissue, mainly in the form of coenzyme A. The highest concentration seen in the liver, adrenal glands, heart and kidneys. Mother's milk for breastfeeding, eating a normal diet, containing about 2 micrograms of pantothenic acid in 1 ml. About 70% of the doses of pantothenic acid oral deduction in the form of unchanged water and about 30% in the feces.

Cyanocobalamin (Vitamin B12) after oral oral is absorbed through the intestine, mainly in the ileum in two mechanisms: the passive mechanism when the amount is high and the mechanism of action allows the absorption of physiological doses, but it is necessary to have intrinsic factors, glycoprotein due to cells into the stomach lining. The level of absorption is about 1% does not depend on the dose and thus taking 1 mg day will satisfy daily needs and sufficient to treat all types of vitamin B12 deficiency.