Vitamin C 500mg khapharco prevention and treatment of Scorbut (200 tablets)

Dosage form Box of 200 tablets
Specifications Acid ascorbic

Ingredient

Composition information	Content
Acid ascorbic	500mg

Uses

Indications

Vitamin C 500mg khapharco is indicated for room and scorbut treatment.

Pharmacokic

ATC code: A11ga01.

Ascorbic acid is a water-soluble vitamin, which is reduced in many oxidative biological reactions. There are some biological functions of ascorbic acid that have been clearly defined, including collagen, carnitin, catecholamine, tyrosin, corticosteroid and aldosterone, so vitamin C is necessary for the development of cartilage, bones, teeth and healing wounds. Ascorbic acid has also participated as a reducing agent in the drug metabolic enzyme system along with Cytochrom P450. The activity of this drug metabolic enzyme system will be reduced without ascorbic acid. Ascorbic acid also regulates absorption, transportation and reserves of iron, affecting the formation of hemoglobin and the formation of red blood cells.

Dynamic pharmacokinetics

absorption: Vitamin C is easily absorbed after drinking, but absorption is a positive process and may be limited after very large doses. Provide regular amount of vitamin C through diets from 30 - 180 mg daily, about 70 - 90% absorbed. At the dose per 1g daily, the absorption decreases to about 50% or less.

In normal human research, only 50% of 1 dose of oral 1.5g of vitamin C is absorbed. Absorption of vitamin C in the stomach - intestines can be reduced in diarrhea or gastric disease.

Normal vitamin C concentration in plasma is about 10 - 20 micrograms/ml. Plasma concentrations below 1 - 1.5 micrograms/ml when scorbut disease. The total amount of vitamin C reserved in the body is estimated at 1.5g with about 30 - 45mg daily rotation. Clinical signs of Scorbut disease often become clear after 3-5 months of vitamin C deficiency.

Distribution: Vitamin C is widely distributed in body tissues. High vitamin C levels are found in the liver, leukocytes, platelets, gland tissue and lens of the eye. About 25% of vitamin C in plasma combined with protein. Ascorbic acid passes through the placenta and distributed in breast milk.

Metabolism and elimination: Ascorbic acid oxygen - Radio chemical into dehydroorscorbic acid. A little vitamin C converted into non-activity compounds including ascorbic acid-2-sulfate and oxalic acid excreted in urine. There is a threshold of eliminating ascorbic acid through the kidneys about 14 micrograms/ml, this threshold may vary depending on each person. When the body saturated ascobic acid and blood concentration exceeds the threshold, ascorbic acid cannot be changed and eliminated into the urine. This is the basis for Ascorbic acid saturated test for vitamin C nutrients. When saturated in tissue and ascorbic acid level in low blood, ascorbic acid eliminates little or does not eliminate into the urine. Ascorbic acid can be removed by hemolysis.

pharmacokinetics

absorption:

Vitamin C is easy to drink, but may be limited after huge doses. In normal people, only about 50% of the oral dose of 1.5g vitamin C is absorbed.

Distribution:

Widely distributed in tissues, about 25% vitamin C in plasma combined with protein.

Era:

Vitamin C oxygen - chemical reversible into dehydroorscorbic acid. A little vitamin C converted into non -active compounds including ascorbic acid - 2 - sulfate and oxalic acid excreted in urine.

The amount of vitamin C exceeding the needs of the body is also quickly eliminated into the urine in the form of unchanged. This usually happens when the daily amount of vitamin C is exceeded 200 mg.

Before taking Vitamin C 500mg khapharco prevention and treatment of Scorbut (200 tablets)

How to use

vitamin C 500mg khapharco oral.

Dosage

Dosage recommended: 1 tablet x 1 - 2 times/day.

There is no special requirement on drug treatment after use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: Diuretic by infusion may work after a large dose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Vitamin C 500mg khapharco that you may encounter.

Increase oxalate. Nausea, vomiting, heartburn, abdominal spasms, fatigue, redness, headache, insomnia and drowsiness have occurred. After taking 1g daily or larger dose, diarrhea may occur.

Common, ADR> 1/100

Kidney: Increased oxalate urine.

Blood: Hemolytic anemia guide how to handle ADR

Do not stop suddenly after using high doses of vitamin C for a long time to prevent the recovery scorbut due to the induction of the metabolism of vitamin C, as it is a physiological response and the consequence of the previous high doses of vitamin C.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin C 500mg khapharco is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when used

Taking high doses of vitamin C can lead to greasy phenomenon, so when reducing the dose, it will lead to a deficiency of vitamin C. Large doses of vitamin C during pregnancy which leads to scorbut disease in newborns.

Increased oxalate oxalate and the formation of calcium oxalate stones in the kidneys may occur after high doses of vitamin C, should avoid high doses of vitamin C for patients with calcium oxalate stones in the kidneys, if necessary, should closely monitor oxalate urinary. Vitamin C can cause acidification of urine, sometimes leading to urate or cystin precipitate, or oxalate stones, or medications in the urinary tract.

Excessive use and prolonged preparations containing vitamin C can cause enamel corrosion.

Using vitamin C can falsify the results of glucose test in urine (fake positive when using copper sulfate reagent or fake negative when using glucose oxidase method).

Taking high doses of vitamin C for a long time can cause dangerous heart disease in humans | There is high amount of iron reserves or people infected with tissue iron.

Can cause hemolysis in newborns G6PD deficiency

It is necessary to consider patients who are eating salt restrictions when using vitamin C in the form of sodium ascorbat. Each gram of sodium ascorbate contains about 5meq Sodium.

High doses, prolonged for pregnant women.

The effect of the drug on the ability to drive and operate machinery

due to the unwanted effect of headache, drowsiness. Patients need to be cautious when participating in activities that require alertness such as driving or operating machinery.

Use drugs for women during pregnancy and nursing mothers

Pregnant women: Vitamin C passes through the placenta, the concentration of umbilical cord blood is 2-4 times the concentration of the mother's blood. If you use vitamin C according to normal needs, there is no problem on people. However, taking large amounts of vitamin C during pregnancy can increase the need for vitamin C and lead to scorbut disease in infants.

breastfeeding women: Ascorbic acid is distributed in breast milk. Mother's milk has a normal diet containing 40 - 70 micrograms of vitamin C/ml, no problem has occurred for babies.

Drug interaction

simultaneously used in the ratio of over 200 mg of vitamin C with 30 mg of elemental iron to increase iron absorption through stomach - intestines; However, most patients have the ability to absorb iron to drink fully without having to use Vitamin C simultaneously.

Simultaneous use of vitamin C with aspirin increases the secretion of vitamin C and reduces aspirin secretion in urine. Salicylate inhibits leukocytes and platelets absorb ascorbic acid.

Therefore, the concentration of ascorbic acid in leukemia and in plasma is reduced, only a little higher than the concentration of people with abnorbic acid deficiency in tissue. However, so far there has been no evidence that Salicylate therapy has promoted ascorbic acid deficiency. Although vitamin C supplements for people who are using salicylate, ascorbic acid levels in plasma increases, ascorbic acid levels in leukemia have not increased and vitamin C reserves in body tissues do not increase. Therefore, vitamin C supplementation for people who are using salicylat is not guaranteed. However, patients who use high doses of salicylat without any symptoms of vitamin C deficiency also need to assess the shortage.

Simultaneous use of vitamin C with fluuphenazin leads to a decrease in plasma fluphenazin levels.

The acidification of urine after using vitamin C can change the excretion of other drugs.

Vitamin C is high doses that can destroy vitamin B12, it is necessary to advise patients to avoid taking vitamin C high doses within 1 hour before or after taking vitamin B12.

Vitamin C can reduce the absorption of selenium (drink at least 4 hours apart).

Vitamin C can increase the effects of hydroxyd aluminum and reduce the effect of amphetamine.

Because vitamin C is a powerful reducing agent, it affects many tests based on oxidation - reducing reactions. The presence of vitamin C in urine increases the amount of glucose if quantitative with copper reagent (II) sulfate and false reduction of glucose amount - if quantified by glucose oxydase method. With other tests, it is necessary to consult a specialized document on the effects of vitamin C.

There are several vitamin C reports that reduce Warfarin's anticoagulant effect, but not sure.

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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