Vitamin C Kabi 500mg/5ml room injection and scorbut treatment (1 blister x 6 tubes)

Dosage form Box of 1 blister x 6 tubes
Specifications Vitamin C

Ingredient

Thành phần cho 5ml

Composition information	Content
Vitamin C	500mg

Uses

Indications

Vitamin C Kabi 500 mg/5 ml is indicated in the following case:

Preventing and treating Scorbut disease, other cases need vitamin C supplementation, when the shortage is acute or unable to use oral.

Pharmacokic

Vitamin C is a water -soluble vitamin, necessary to synthesize collagen and components of connective tissue. The human body cannot produce vitamin C for themselves but must be taken from the source of food. Vitamin C deficiency will lead to Scorbut disease. The lack of manifestations in symptoms of bleeding easily, fragile capillary walls, anemia, cartilage and bone damage, slowly seamless wounds.

Ascorbic acid has the ability to reduce in many oxidation - reduction biological reactions. There are some biological functions of ascorbic acid that have been clearly defined, including collagen biosynthesis, carnitin, catecholamine, tyrosin, corticosteroid, aldosteron. Ascorbic acid has also participated as a reducing agent in the drug metabolic enzyme system along with Cytochrom P450. The activity of this drug metabolic enzyme system will be reduced without ascorbic acid.

Ascorbic acid also regulates absorption, transportation and iron reserves.

Ascorbic acid is an effective antioxidant protection. Ascorbic acid eliminates oxygen, reaction nitrogen, free oxygen and hypocloride are free radicals that are toxic to the body.

Ascorbic acid in white blood cells is especially important because there is ROS (Reactive Oxygen Species) generated during leukocytes or active leukocytes due to inflammation. High ascorbate concentration in leukemia protects leukemia against oxidation damage without inhibiting the bactericidal activity of the microbiological body. The antioxidant activity of ascorbic acid also protects against protein breakdown in inflammatory positions such as joints and lungs.

Ascorbic acid can regulate prostaglandin synthesis, have bronchodilator, vasodilator and anticoagulant, the ability to convert folic acid into folinic acid, convert carbohydrates, synthesize lipids, proteins, resist bacterial and cell respiration.

pharmacokinetics

absorption:

Not applicable.

Distribution:

Vitamin C is widely distributed in body tissues. High vitamin C levels are found in the liver, leukocytes, platelets, gland tissue and lens of the eye. About 25% of vitamin C in plasma combined with protein. Ascorbic acid passes through the placenta and distributed in breast milk.

Metabolism:

Acal acid ascorbic oxidizes reversible into dehydrooscorbic acid. A little vitamin C converted into non -activity compounds including ascorbic acid - 2 - sulfate and oxalic acid.

Era:

There is an abnormal excretion threshold of about 14 mcg/ml, this threshold may vary depending on each person. When the body saturated ascorbic acid and blood levels in excess of the threshold, ascorbic acid cannot be changed and eliminated into the urine. When saturated in tissue and ascorbic acid levels in low blood, ascorbic acid eliminates less or not excreted into the urine. Ascorbic acid can be removed by hemolysis.

Before taking Vitamin C Kabi 500mg/5ml room injection and scorbut treatment (1 blister x 6 tubes)

How to use

Only in special cases when it is impossible to drink or when suspected of being absorbed by the injection.

Can be intramuscular, intravenous or subcutaneous, it is best to intramuscularly.

Dosage

Adults:

0.5-1 g/day to treat Scorbut.

200 - 500 mg/day to prevent scorbut.

Children:

100 - 300 mg/day to treat scorbut disease.

30 mg/day to prevent scorbut.

Old people:

There is no special dose requirement.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Expression:

Kidney stones, nausea, gastritis, diarrhea.

Management:

Diuretic by infusion can work after large dose.

What to do when forgetting a dose?

This drug is done in medical facilities. In case of forgetting the rare dose.

Side Effects

When using Vitamin C Kabi 500 mg/ 5 ml, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: digestive disorders, including diarrhea when taking high doses.

urinary tract: Increase oxalate and can form oxalate stones in the kidneys if urine becomes acidic when taking high doses for a long time. The dose of 600 mg or more daily has diuretic effects. High doses for a long time can cause deficiency symptoms when reduced the dose to normal levels.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vitamin C Kabi 500 mg/5 ml contraindicated in the following case:

Increase oxalate.

Be cautious when used

Taking high doses of vitamin C can lead to greasy phenomenon, so when reducing the dose will lead to vitamin C deficiency.

Increased oxalate oxalate and the formation of calcium oxalate stones in the kidneys may occur after high doses of vitamin C, should avoid high doses of vitamin C for patients with calcium oxalate stones in the kidneys, if necessary, should closely monitor oxalate urinary. Vitamin C can cause acidification of urine, sometimes leading to urate or cystin precipitate, or oxalate stones, or medications in the urinary tract.

Vitamin C high doses of intravenous injection has been fatal, so intravenous use is an unreasonable and unsafe use.

Patients with G6PD deficiency with high doses of vitamin C intravenously may have hemolytic.

Deep vein thrombosis also occurs after high doses of vitamin C.

Using vitamin C can falsify the results of glucose test in urine (fake positive when using copper sulfate reagent or fake negative when using glucose oxidase method).

can cause hemolysis in infants deficiency G6PD.

It is necessary to consider patients who are eating salt restrictions when using vitamin C in the form of sodium ascorbat. Each gram of sodium ascorbate contains 5 meq sodium.

Use carefully with people with a history of kidney stones, oxalate oxalate and oxalate metabolic disorders (increased risk of kidney stones), thalassemia disease (increased risk of iron absorption).

No high doses, prolonged for pregnant women.

The ability to drive and operate machinery

Vitamin C Kabi 500 mg/5ml usually does not affect the ability to drive or operate machinery.

Pregnancy

Ascorbic acid passes through the placenta, the blood concentration in the umbilical cord is 2-4 times the concentration of the mother's blood. Vitamin C 500 mg/5ml not for pregnant women.

Lactation period

Ascorbic acid distributed in breast milk, can be used as directed by a doctor.

Interactive drug

Simultaneously used in the ratio of over 200 mg of vitamin C with 30 elemental iron to increase iron absorption through stomach - intestines.

Simultaneous use of vitamin C with aspirin reduces the absorption and increased secretion of vitamin C and reduces aspirin secretion in urine.

Simultaneous use of Vitamin C and Fluphenazin leads to a decrease in plasma fluphenazin levels.

Vitamin C high doses can destroy vitamin B12.

Vitamin C can increase the effect of aluminum hydroxyd and reduce the effect of amphetamine.

Because vitamin C is a powerful reducing agent, it affects many tests based on reducing oxygen reactions. The presence of vitamin C in urine increases the amount of glucose amount if quantitative with copper reagent (II) sulfate and false reduction of glucose amount if quantitative by glucose oxydase. With other tests, it is necessary to consult a specialized document on the effects of vitamin C.

High doses of vitamin C can reduce the effect of oral anticoagulants.

Medications that reduce the saturation of vitamin C in tissue including aspirin, nicotine from cigarettes, alcohol, iron, phenytoin, some anticonvulsants, tetracycline, estrogen in oral contraceptive pills, some drugs that cause anorexia.

High doses of vitamin C can cause urine acidification causing reabsorption in the renal tubules of acidic drugs, creating an overdose reaction. In contrast, high doses of vitamin C reduces the reabsorption in the renal tubules of base drugs, leading to reduced treatment effect.

Use a combination of ascorbic acid with desferrioxamin in patients with iron overload to increase iron elimination can worsen iron poisoning, especially on the heart in the early stages of treatment when the iron level is too large. Therefore, it is recommended that patients with normal heart function should not supplement ascorbic acid in the first month after starting to use desferrioxamin. Do not use ascorbic acid with desferrioxamin in patients with heart dysfunction.

Patients with renal failure using antacids containing aluminum and oral citrate can cause a potential death brain disease due to increased aluminum concentration in the blood. There is evidence of vitamin C can also cause similar interaction.

Oral contraceptives reduce ascorbic acid levels in plasma.

The cavalry of the drug:

Physical vitamin C injection drugs with penicillin gel medicine.

Ascorbic acid is not compatible with iron salts, oxidative elements and salt of heavy metals, especially copper.

Ascorbic acid injection has been reported as incompatible with aminophyllin, BLEOYMYCIN SULFAT, Erythromycin Lactobionate, Sodium Nafcillin, Sodium Nitrofurantoin, Estrogen combined, sodium bicarbonate and sulphafurazon diethanolamine. Not frequent compatibility, depending on the pH and concentration that occurs with chloramphenicol sodium sucinat.

Storage

Avoid light, temperature not exceeding 30 ° C.

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