Vitamin C MKP 500mg Mekophar and Scorbut treatment (20 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 20 blisters x 10 tablets
Ingredient Vitamin C
Indication Scorbut disease
Contraindication Kidney stones, urinary stones, anemia due to glazed G6PD, Thalassemia

Ingredient

Composition information	Content
Vitamin C	500mg

Uses

indications

Vitamin C MKP 500 drug is indicated in the following cases:

Preventy and treatment of Scorbut (Vitamin C).

Urine acidosis Some biological functions of ascorbic acid have been clearly defined, including collagen, camnitin, catecholamine, tyrosine, corticosteroids and aldosteron. Vitamin C also participates as a reducing agent in the enzyme metabolic system with Cytochrome P450. The activity of this metabolic enzyme system will be reduced without vitamin C. Vitamin C is necessary to synthesize collagen and other connective tissue components. Vitamin C also regulates absorption, transportation and reserves of iron.

Vitamin C is an effective antioxidant protective agent by removing oxygen, reaction nitrogen (ROS, RNS such as hydroxy, peroxyl, superoxide, peroxide and nitroxide), free oxygen and hypochlorite, are free radicals that are harmful to the body.

Daily needs through a diet requires about 30–100 mg of vitamin C for adults. However, this need varies depending on each person. The deficiency of vitamin C occurs when the food provides not enough vitamin C needed, leading to Scorbut.

Vitamin C deficiency is very rare in adults, but can be seen in young children, alcoholics or the elderly. Vitamin C deficiency is manifested in symptoms of bleeding (small blood vessels, tooth, gums), fragile capillary walls, anemia, cartilage and bone damage, slowly seamless wounds. Use vitamin C completely losing the above symptoms.

pharmacokinetics

absorption:

Vitamin C is easily absorbed after drinking. However, absorption is a positive process and may be limited after huge doses. Provide regular vitamin C through diets from 30–180 mg daily, about 70–90% are absorbed.

Take the dose per 1 g daily, the absorption decreases to about 80% or less. In normal human research, only about 50% of a dose of 1.5 g vitamin C is absorbed.

Vitamin C absorption in the stomach can decrease in diarrhea or stomach disease. Normal vitamin C concentration in plasma is about 10–20 mcg/ml. Plasma concentrations below 1–1.5 mcg/ml when scorbut disease. The total amount of vitamin C reserved in the body is estimated at 1.5 g with about 30–45 mg daily rotation.

Distribution:

Vitamin C is widely distributed in body tissues. High vitamin C levels are found in the liver, leukocytes, platelets, gland tissue and lens of the eye. About 26% of vitamin C in plasma combined with protein. Vitamin C passes through the placenta and is distributed in breast milk.

Metabolism - except:

Acal acid ascorbic oxidizes reversible into dehydrooscorbic acid. A little ascorbic acid metabolizes into non-activity compounds including ascorbic acid-2-sulfate and oxalic acid excreted in urine.

The threshold of abnorbic acid discharged through the kidney is about 14 mcg/ml, this threshold may vary depending on each person. When the body saturated ascorbic acid and blood concentration beyond the threshold, ascorbic acid is unchanged and eliminated into the urine.

Before taking Vitamin C MKP 500mg Mekophar and Scorbut treatment (20 blisters x 10 tablets)

How to use

Vitamin C MKP 500 medicine for oral. Should take medicine when full, do not take the medicine in the evening before going to bed.

Dosage

Dosage: According to the doctor's instructions.

Recommended dose:

Children:

Scorbut disease: Take 100–300 mg/day, divided into several times. Should use other preparations with more appropriate content.

Endulge urine: Take 500 mg/time, 6–8 hours of drinking 1 time.

Adults:

Scorbut disease: Take 100–250 mg/time x 1–2 times/day.

Endulge urine: Drink 4–12 g/day, divided into 3–4 times.

Methemoglobin blood idiopathic: Take 300–600 mg/day, divided into small doses.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Vitamin C MKP 500, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Kidney: increased oxalate urine.

Uncommon, 1/1000

Blood: Anemia hemolysis.

Cardiovascular: flushed, heart failure.

Central nervous system: fainting, dizziness, headache, fatigue, insomnia, drowsiness.

Stomach: Nausea, vomiting, heartburn, abdominal pain, abdominal spasms, bloating, diarrhea.

Neurological and bone: pain edge.

Instructions on how to handle ADR

Do not stop the patient suddenly after taking vitamin C high doses for a long time to prevent recurrent scorbut disease, due to the induction of the metabolism of vitamin C because it is a physiological response and the consequence of the previous high -dose vitamin C use.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Vitamin C MKP 500 is contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Do not use high doses of vitamin C for patients with glucose-6-phosphate dehydrogenase (risk of hemolytic anemia).

Be cautious when used

Take vitamin C high doses, prolonged can lead to poor tolerance phenomenon, so when reducing the dose will lead to vitamin C. deficiency deficiency

Take a large dose of vitamin C during pregnancy will lead to scorbut disease in newborns.

Increased oxalate oxalate and the formation of calcium oxalate stones in the kidneys may occur after high doses of vitamin C. Should avoid high doses of vitamin C for patients with calcium oxalate stones in the kidneys. If necessary, it is necessary to closely monitor oxalate urine. Use carefully in patients with a history of kidney stones, increased oxalate urine and oxalate metabolic disorders (increased risk of kidney stones), thalassemia disease (increased risk of iron absorption).

Vitamin C can cause urine acidification, sometimes resulting in Urate precipitation, cystine, oxalate stones or medications in the urinary tract.

Patients with glucose-6-phosphate dehydrogenase-deficiency of oral doses of vitamin C may have hemolytic.

High doses of vitamin C can cause deep vein thrombosis.

Excessive drink and prolonged preparations containing vitamin C can cause enamel corrosion.

Using vitamin C can falsify the results of glucose test in urine (fake positive when using copper sulfate reagent or fake negative when using glucose oxidase method).

Taking high doses of vitamin C for a long time can cause dangerous heart disease in people with high iron reserves or people infected with tissue.

The ability to drive and operate machinery

Caution when used for drivers and operating machinery, people working on high and other cases because the drug can cause headaches, dizziness, fatigue.

Pregnancy

Vitamin C passes through the placenta. Taking high, prolonged doses of vitamin C can increase the demand for vitamin C and lead to scorbut disease in newborns. Be cautious when used for women during pregnancy.

breastfeeding period

vitamin C distributed in breast milk. Caution should be careful when using high doses of vitamin C and prolonged for nursing women.

Medicinal interaction

simultaneously used in the ratio of over 200 mg of vitamin C with 30 elemental iron that increases iron absorption through the stomach. However, the majority of patients have the ability to absorb oral iron well without having to use it simultaneously with vitamin C.

Simultaneous use of vitamin C with aspirin increases the secretion of vitamin C and reduces aspirin secretion in urine.

Salicylate inhibits leukocytes and platelets that absorb vitamin C. Therefore, vitamin C levels in leukemia and in plasma are reduced, only a little higher than the concentration of people with vitamin C deficiency in tissue. However, so far there is no evidence that Salicylate therapy has promoted vitamin C deficiency. Although vitamin C supplementation for people who are using salicylate, vitamin C levels in plasma increases, vitamin C levels in leukemia and body tissue do not increase. Therefore, vitamin C supplementation for people who are using salicylate is not guaranteed. However, patients taking high doses of salicylate without any symptoms of vitamin C deficiency also need to assess the shortage.

Simultaneous use of Vitamin C and Fluphenazine reduces fluphenazine levels in plasma.

The acidification of urine after using vitamin C can change the excretion of other drugs.

Vitamin C high doses can destroy vitamin B12. It is necessary to advise patients to avoid taking vitamin C high doses within 1 hour before or after taking vitamin B12.

Vitamin C can reduce the absorption of selenium (drink at least 4 hours apart).

Vitamin C can increase the effects of hydroxide aluminum and reduce the effects of amphetamine.

Vitamin C is a powerful reducing agent that greatly affects tests based on oxidation reactions. The presence of vitamin C in urine increases the amount of glucose if quantitative with copper reagent (II) sulfate and false reduction of glucose amount if quantitative by glucose oxydase method.

There have been a few vitamin C reports that reduce Warfarin's anticoagulant but not sure.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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