Vitamin PP 500mg Mekophar Treatment Treatment Pellagra (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Nicotinamid

Ingredient

Thành phần cho 1 viên

Composition information	Content
Nicotinamid	500mg

Uses

indications

Vitamin PP 500mg drug is indicated in the following cases:

Treatment of Pellagra disease. In the body, nicotinamid is converted into nicotinamid adenin dinucleotid (NAD) or Nicotinamid adenin Dinucleotid phosphate (NADP) catalyzed oxidation - reduction reaction, necessary for cell respiration, Glycogen resolution and lipid transformation.

pharmacokinetics

absorption and distribution

Nicotinamid is quickly absorbed through the gastrointestinal tract after drinking and distributed throughout the body tissue.

Metabolism and elimination

The sale time of the drug is about 45 minutes. Nicotinamid metabolizes the liver into N - methylnicotinamide, derivatives 2 - pyridon and 4 - pyridon. After using nicotinamid in normal doses, only a small amount of nicotinamid excreted into the urine in the formless form; However, when taking large doses, the amount of excretion in the form of unchanged will increase.

Before taking Vitamin PP 500mg Mekophar Treatment Treatment Pellagra (10 blisters x 10 tablets)

How to use

vitamin PP 500mg is a oral medication. Take medicine with a full glass of water.

Dosage

Adults

Take 1 capsule/time, 1-3 times a day. No more than 3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

There has not been a report on the case of nicotinamide overdose.

How to handle

When an overdose occurs, there is no specific detoxification measure. Use common measures such as vomiting, gastric lavage, symptomatic treatment and support.

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using vitamin PP 500mg you can experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea.

Uncommon, 1/1000

Digestive: progressive stomach ulcers, vomiting, anorexia, pain when hungry, flatulence, diarrhea.

Skin: dry skin, hyperpigmentation, jaundice, rash.

Metabolism: liver failure, reducing glucose tolerance, increased sebaceous secretion, gout worse.

Other: hyperglycemia, hyperuricemia, vagus - blood vessels, headache and blurred vision, dry eyes, swelling of the eyelids, dizziness, heart beating fast, fainting, wheezing.

Rare, ADR

Neurology: Anxiety, panic, insomnia.

Kidney: Urine glucose.

Liver: Unusual liver function includes increased serum bilirubin, AST (SGOT), ALT (SGPT) and LDH.

Blood: Prothrombin time is abnormal, lowering blood albumin, anaphylaxis.

muscle - bone: muscle pain.

Cardiovascular: lower blood pressure.

Respiratory: rhinitis.

Instructions on how to handle ADR

Most patients use high doses such as the dose to treat Pellagra, often flushing and neck (in areas prone to red), and are more related to serum concentration rate rather than the total serum concentration of the drug. To limit that unwanted effect, should take medicine with food, increase the dose slowly.

Stop taking the drug if there is any of the following symptoms: Symptoms like the flu (nausea, vomiting, generally feel unwell), reduce the amount of urine and urine dark, discomfort in muscle (swelling, soft or muscle weakness), abnormal heart rate, blurred or gloomy.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vitamin PP 500mg is contraindicated in the following cases:

Hypersensitivity to nicotinamid or any ingredient of the drug.

Severe liver disease.

progressive stomach ulcer.

arterial hemorrhage.

Hypotension is severe.

Be cautious when using

should do tests on liver function and blood glucose before treatment with nicotinic acid or nicotinamide for patients for a long time with high doses beyond physiological needs, every 6-12 weeks in the first year and periodically in the following years.

When using high doses of nicotinamid for the following cases: History of gastrointestinal ulcer, acute coronary artery syndrome, gallbladder disease, a history of jaundice or liver disease, kidney disease, gout, gout arthritis, diabetes. Ethrosin -containing preparations, several studies show that Erythrosin causes mouse thyroid tumors and affects the function of the thyroid gland, but there is no firm conclusion about these effects.

Preparation containing Sunset Yellow is a colorant that can cause allergic reactions in some patients with sensitive atopic, redness, urticaria, shortness of breath, drowsiness or lower blood pressure.

Products containing lactose, cautious for patients with rare genetic disorders in galactose tolerance, lactase lactase deficiency or glucose - galactose absorption disorders.

The ability to drive and operate machinery

Caution when used for train drivers or operating machines because the drug can cause dizziness, headache, blurred vision.

Pregnancy

Do not use this drug for pregnant women, nursing women.

breastfeeding period

Do not take this medication for breastfeeding women.

Interactive drug

Interaction of drugs

Use nicotinamid simultaneously with HMG - CoA Reductase inhibitors may increase the risk of muscle eligibility. Using nicotinamid simultaneously with alpha - adrenergic blockers treating hypertension can lead to excessive hypotension.

Diet and/or dosage of hypoglycemic or insulin medication may need to be adjusted when used simultaneously with nicotinamid.

Nicotinamid use simultaneously with toxic drugs with the liver can increase the toxic effect of the liver.

Do not simultaneously use nicotinamid with carbamazepin because of increased plasma carbamazepine levels, leading to increased toxicity.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.