Vizicin 125 Hasan medicine for bacterial infections (30 packs x 1.5g)

Dosage form Box of 30 packs x 1.5g
Specifications Azithromycin

Ingredient

Composition information	Content
Azithromycin	125mg

Uses

indications

vizicin drugs are indicated in cases of infections caused by drugs that are sensitive to drugs such as:

Lower respiratory infections such as pneumonia , acute bronchitis due to Haemophilus influenzae, Moraxella Catatrhalis, Streptococcus pneumoniae. Between . Drugs. The drug has a strong bactericidal effect by attaching to ribosomes of pathogenic bacteria, preventing their protein synthesis.

azithromycin works well on gram -positive bacteria (streptococcus, pneumococcus, staphylococcus aureus). In Vietnam, these species are about 40%resistant to macrolid groups, so somewhat as the ability to use azithromycin is limited. Some other bacteria strains are also very sensitive to azithromycin such as corynebacterium diphtheriae, Clostridium perfringens, peptostreptoccus, propionibacterium acnes.

Azithromycin works well in gram -negative bacteria (Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella Catatrhalis, Acinetobacter, Yersinia, Legionella Pneumophila, Bordella Pertussis, Bordetella Parapertussis; Neisseria Gonorrhoeae, Campylobacter sp. In addition, this antibiotic is also effective with Listeria Monocytogenes, Mycobacterium Avium, Mycoplasma Pneumoniae, Mycoplasma Hominis, Ureawlasma ureaum, Toxoplasma Gondii, Chlamydia Trachomatis, Chlamydia Pneumoniae, Treponema Pallidum, Borrelia Burgdorferi.

Azithromycin has a moderate effect on Gram -negative bacteria such as E. Coli, Salmonella Enteritis, Salmonella Typhi, Enerobacter, Aeromonas Hydrophila, Klebsiella.

Erythromycin anti -Erythromycin strains may also be resistant to azithromycin as gram -positive strains, including Enterococcus species and most staphylococcus strains of methicillin resistant. The Gram -negative strains are anti -Azithromycin, Proteus, Serratia, Pseudomonas Aeruginosa and Morganella.

Pharmacokinetics

absorption

After drinking, Azithromycin is widely distributed in the body, about 40%bioavailability. Food reduces the ability to absorb Azithromycin by about 50%. After taking the drug, the plasma peak concentration is achieved within 2 - 3 hours.

Distribution

The drug is distributed mainly in lung tissue, tonsils, prostate glands, granulocytes and macrophages ..., many times higher in the blood (about 50 times the maximum concentration in plasma). However, the concentration of the drug in the central nervous system is very low.

Metabolism

Small amount of azithromycin is reduced methyl in the liver and is eliminated through bile in the form of unchanged and partly metabolic form.

Elimination

About 6% of oral dosage except for urine within 72 hours in non -variable form.

Before taking Vizicin 125 Hasan medicine for bacterial infections (30 packs x 1.5g)

How to use

Dissolve the powder with a little warm water, stir and drink. Drink once a day, should drink 1 hour before meals or at least 2 hours after eating.

Dosage

Adults:

Respiratory infections above and below, skin infection and soft tissue. The first day of taking 1 dose of 500 mg, 4 days after single dose 250 mg/day.

Genital transmission disease caused by chlamydia trachomatis, Haemophilus ducreyi, Neisseria gonorrhoeae: Take the only dose of 1 g.

Older people, patients with renal failure or mild liver failure:

No dose adjustment.

Children under 12 years:

Unique dose per day: 10 mg/kg/day for 3 days or the first day 10 mg/kg/time/day, 4 days for 5 mg/kg/time/day.

There is no information on the effectiveness and safety of azithromycin when used for children under 6 months old. Do not take medicine for this object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

There is no specific treatment when overdose. Treatment by gastric lavage and supportive treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using vizicin , you may experience unwanted effects (ADR).

The drug is well tolerated. Most side effects in medium and light, can recover when discontinued.

Common, ADR> 1/100

Gastrointestinal disorders (10%): indigestion, flatulence, diarrhea, nausea, abdominal pain, abdominal spasms, vomiting (usually mild, less occur than using erythromycin).

Rare, 1/10000

Intense disorders

infection: nephritis, vaginitis ...

nerve: headache, drowsiness, dizziness, dizziness, fatigue ...

Skin: Rashes, edema, light sensitivity, peripheral angio ...

Recovery hearing in some patients taking high doses at high doses.

Mentality reduction of the number of neutrophils, fleeting in clinical trials but has not clearly defined the relationship with the medication.

Increased liver transaminase recovery. Some cases of liver abnormalities such as hepatitis, jaundice have been reported.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

vizicin drugs contraindicated in the following cases:

Too hypersensitivity to azithromycin or any antibiotic belonging to the macrolid group.

Children under 6 months of age.

Be cautious when used

Need to adjust the dose for patients with liver failure, renal failure (CLCR

The risk of bacterial infections is not sensitive and fake colitis when using broad spectrum antibiotics such as azithromycin.

Be cautious because azithromycin has the potential to cause allergies such as vascular nerves and anaphylaxis.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

There is no research data on pregnant women. Only use azithromycin when there are no other appropriate drugs.

The period of breastfeeding

There is no research data on breastfeeding women.

It is unclear whether azithromycin is excreted in milk. Therefore, it is necessary to be careful when prescribing the drug for breastfeeding women.

Drug interaction

Food reduces the bioavailability of drugs by up to 50%.

Unsert unused Azithromycin with chicken spurs derivatives due to the risk of chicken poisoning.

Only use azithromycin at least 1 hour ago or at least 2 hours after taking antacids.

Because azithromycin affects digoxin, cyclosporin metabolism, the dose should be monitored and adjusted (if necessary) when using the above drugs.

Coumarin anticoagulant drugs: can be used simultaneously Warfarin and azithromycin but still have to monitor the patient's blood clotting time.

Neutral leukemia when used in combination with rifabutin with azithromycin.

There has been no dynamic effect when used in combination with azithromycin and theophyllline, but still have to monitor theophyllline concentration when shared with these two drugs.

azithromycin has little effect on the pharmacokinetics of carbamazepin, cimetidine, methylprednisolon.

Storage

Store in a dry place, below 30 ° C. Avoid moisture and light.

Other drugs

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