Warfarin 5 S.P.M Medicine Short -term treatment of venous thrombosis and acute pulmonary embolism (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Warfarin

Ingredient

Composition information	Content
Warfarin	5mg

Uses

indications

Warfarin 5 drugs are indicated in the following cases:

Short -term treatment: Venous thrombosis and acute pulmonary obstruction, at the beginning of treatment in combination with heparin. Heart disease is at risk of vascular congestion such as ventricular vibration, replacement of heart valves, people with transient ischemia, brain congestion. Coronary artery disease (angina, myocardial infarction).

Warfarin prevents prothrombin synthesis (coagulation factor II), Proconvertin (factor VII), anti hemophilia B element (factor X) and Stuart - Prower factor (factor X) by preventing the activity of vitamin K inherently necessary for the synthesis of these blood coagulation elements in the liver.

The sale time of these factors is very different, the effect of Warfarin's blood clotting usually starts to appear within 24 hours, but it may take 3-4 days to achieve the highest effect. Blood prevention effects usually reach after 5 days. If it is necessary to work quickly, use Heparin at the beginning of using warfarin until the desired results are achieved.

Dynamic pharmacokinetics

After drinking, warfarin is absorbed quickly and completely. All anticoagulant drugs are strongly linked to plasma proteins (98 - 99%).

Selling time is 22 - 35 hours, mainly through the kidneys after metabolism in the liver by cytochrome P450. This metabolism may be inhibited by some drugs such as cimetidine, causing danger bleeding. Some other drugs inhibit warfarin metabolism such as propafenone, increasing blood warfarin levels about 40% and increasing prothrombin time in the corresponding way. Amiodarone increases the concentration of warfarin, because Amiodarone has a very long selling time, up to 50 days, so it can cause serious interaction after treatment.

always attach importance to the risk of drug interaction. After stopping using warfarin, prothrombin returns to normal within 4-5 days.

Metabolic substances have no anticoagulant effect, and excretion in urine after reabsorption from bile.

Before taking Warfarin 5 S.P.M Medicine Short -term treatment of venous thrombosis and acute pulmonary embolism (3 blisters x 10 tablets)

How to use

oral medication. Must take the drug at the same time specified in the days.

Dosage

Initial dose

Dosage is determined for each person.

Dosage depends on INR (international standardized ratio):

INR = Patient's Quick Time/Standard Quick Time = PTR (ISI).

In it:

pt = Quick time.

PTR = The ratio between the patient's quick time is divided by the standard time.

ISI is an international sensitivity index (of thromboplastin used compared to Thromboplastin international reference standard). Thus the ISI of the sample by definition is 1.

Inr of normal people 5, the risk of strong bleeding.

The first dose usual 5 - 10 mg/day for the first 2 days, then adjusted based on the results of Inr.

Elderly people often use low initial dose.

When anticoagulant is needed, use heparin in the first days (injection or subcutaneous). Warfarin treatment may either either or at the same time with heparin, or start after heparin.

Maintenance dose

Most patients are maintained at a dose of 2 - 10 mg/day. Treatment time depends on each person. Typically, anticoagulant therapy must be prolonged when the risk of obstruction is over.

The range of INR's oscillation is recommended:

INR = 2.0 - 3.0: Blood room - clogging for high -risk internal or surgical patients; Treatment of close venous thrombosis and pulmonary embolism, body congestion in patients with atrial fibrillation, valve disease, biological valve or acute myocardial infarction.

INR = 3.0 - 4.5: Prevention of congestion in people with mechanical heart valves or in people with recurrent body congestion.

Periodic Monitoring PT/INR: PT/INR must be determined before treatment. In the first 2 weeks, determine daily or 2 to 3 times per week. Then, every month in the patient was balanced or 1/2 month, if necessary.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? For vitamin K, oral or injection 5 - 10 mg.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Warfarin 5, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Bleeding.

Uncommon, 1/1000

Digestive: diarrhea.

DA: Red Red. hair loss.

Rare, 1/10000

Vasculitis, skin necrosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Warfarin 5 contraindications in the following cases:

Patients who do not cooperate well (do not comply with the doctor's instructions).

Malignant high blood pressure.

severe hemostatic disorders, severe liver disease, cirrhosis, fat stool.

Severe kidney failure. u, gastrointestinal ulcers or genital tract (easy to bleed).

Acute or new surgery in the central nervous system.

However, some patients if needed are still used for treatment, but must be very cautious.

Caution when using

Some factors affecting the effects of drugs such as diet, habitat.

closely monitor people with liver disease, severe heart failure, atrial fibrillation, hyperthyroidism, fever. Elderly people are at risk of serious injury (eg thigh fracture) and physiological changes in subcutaneous and joint tissues, which can cause uncontrolled bleeding.

The following factors can increase the effects of warfarin and need to reduce the dose: people who lose weight, elderly, seriously ill, kidney failure, eat vitamin K.

Factors may need to increase the maintenance dose: weight gain, diarrhea, vomiting, use lots of vitamin K, fat and use some drugs. It is necessary to do the necessary tests when changing the drug form. The effect of warfarin is reversed.

The ability to drive and operate machinery

has not recorded any cases that affect the operation of the train machinery when taking this drug, if you need more information, please consult your doctor.

Pregnancy

Not for pregnant women.

Warfarin and anticoagulants of the Coumarin group through the placenta fence and cause dots of bone cartilage, bleeding and fetal death. Warfarin also increases the risk of bleeding in the mother in the middle 3 months and the last 3 months of pregnancy. It is not recommended to use coagulating drugs of Coumarin during pregnancy. If you need anticoagulant during pregnancy, heparin should be used, because this drug does not go through the placenta.

breastfeeding period

Warfarin does not excrete through breast milk, so it can be used for nursing women.

Drug interaction

The drug increases the effects of warfarin: amiodarone, amitryptyline/nortriptyline, steroids as assimilation, azapropazon, bezafibrate, cefamandol, chlorine hydrate, chloramphenicol, cimetidine, clofibrat, cotrimoxazol, danazol, danazol, danazol, danazol, danazol, danazol, danazol, danazol Dextropoxyphen, dextrothyroxin, dipyridamol, erythromycin, feprazon, latamoxef, metronidazole, miconazole, neomycin, oxyphenbutazon, glucagon, phenformin, phenylbutazon, phenyramidol, quinidine, salicylate, sulfonami (example: example: example: example: example: example: Example: Sulfaphenazol, SulfinPyrazon), Tamoxifen, Tolbutamide and Triclofos, 3 -round antidepressants, urinase, vitamin E, anti -influenza vaccine.

The drug increases or decreases the effects of warfarin: phenytoin, acth, corticosteroids.

Medications reduces the effects of warfarin: alcohol (alcoholism), aminoglutethimid, barbiturate, carbamazepine, ethlorvyol, glutethimid, griseofulvin, dicontalphenazon, methaqualon, primidon, rifampicin, oral contraceptive pills containing Orestrogen, Spironolacton, SucRalFate, vitamins, vitamins, vitamins K.

Storage

In a dry place, avoid light, temperature below 30ºC.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.