Waruwari 2mg medicine Davi Pharm treat muscle spasticity (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tizanidin

Ingredient

Composition information	Content
Tizanidin	2mg

Uses

indications

Waruwari drugs are indicated in the following cases:

Treatment of muscle spasticity caused by scattered sclerosis or spinal cord damage.

muscle or shock.

Pain caused by muscles.

Pharmacology

tizanidin is the agonist α2 - adrenergic, impact on the central nervous system of the spinal cord and on the spinal cord. The medication reduces muscle spasms by increasing the amount of money synap of motor neurons at the receptor α2 - adrenergic. Tizanidine works mainly on neurons with many synap. The result is to reduce the process of stimulating movement neurons on the spinal cord so it reduces muscle contraction and does not cause excessive muscle weakness. The drug has the maximum effect after taken 1.5 hours and the effect after about 3-6 hours. On experimental animals, tizanidin does not act directly on the musculoskeletal fibers or nerve -muscle movement, does not work on the single canal reflex synap. In addition, tizanidin can reduce blood pressure due to drugs attached to imidazoline receptors, but this effect is much weaker than clonidin.

pharmacokinetics

tizanidin well absorbed by oral. After taking about 1.5 hours, the drug reaches the peak concentration in plasma and has the maximum effect, all the effect is about 3-6 hours. Due to the initial metabolism through the liver, oral bioavails reached about 40%. Food does not affect the level of absorption that affects the absorption rate such as shortening the time to reach the peak concentration of about 40 minutes and increasing the peak concentration in plasma about 33%.

tizanidine binds to low plasma proteins, about 30%. The drug is distributed throughout the body, the average distribution volume is 2.4 kg after intravenous use. About 95% of the dose is metabolized through the liver. The half -life of Tizanidin is 2.5 hours, of the metabolites no longer active about 20 - 40 hours.

tizanidin eliminates through the kidney 60%, passes 20%. In the elderly, eliminated by 4 times compared to young people. If attached to renal failure (creatinine clearance coefficient

Before taking Waruwari 2mg medicine Davi Pharm treat muscle spasticity (10 blisters x 10 tablets)

How to use

Waruwari is oral medication.

Oral medication, has a relatively short effect, so it must be taken several times a day (3-4 times/day) depending on the needs of the patient. Need to adjust the dose depending on the response of the patient. Do not exceed the desired treatment effect. Dosage is calculated in tizanidin base.

Dosage

Adults

Treatment of muscle spasticity:

Normal starting dose: 2 mg 1 single dose. After that, depending on the response of each patient, the dose may increase gradually 2 mg, at least 3-4 days apart, up to 24 mg/day divided into 3-4 times. The maximum recommended dose is 36 mg/day.

Treatment of muscle pain:

Take 2 - 4 mg/time, drink 3 times a day. For people with renal failure with creatinine clearance

Elderly

The usual dose is like young people. The dose can be adjusted because the renal clearance can be reduced four times compared to young people.

Children

has not determined the level of safety and effectiveness of the drug.

Severe liver failure

Contraindications.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

Use common poisoning treatments to eliminate drugs such as gastric lavage, active carbon and diuretic such as Furosemid, Manitol.

Also using respiratory, cardiovascular, water and electrolytes.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Waruwari, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: dry mouth, abdominal pain, diarrhea, indigestion.

Muscle muscle: Myasthenia, back pain.

central nervous system: drowsiness, sleep, fatigue, dizziness, depression, anxiety, abnormalities, hallucinations.

Skin: rash, sweating, skin ulcers.

Other: Fever.

Uncommon, 1/1000

Cardiovascular: vasodilation, hypotension standing, fainting, migraine, arrhythmia.

digestive: difficulty swallowing, gallstones, flatulence, gastrointestinal bleeding, hepatitis, black stool.

Hematoma: Hematoma, hypercholesterolemia, anemia, hyperemia, decreased or leukemia.

Metabolic: edema, reduce thyroid activity, lose weight.

Bone muscle: Pathological fracture, arthritis.

Central nerve: Run, easy to touch, convulsions, paralysis, thinking disorders, dizziness, dreaming, personality disorders, migraine, dizziness, nerve pain.

Respiratory: sinusitis, bronchitis.

skin: itching, dry skin, acne, hair loss, urticaria. sensory: Ear pain, tinnitus, deafness, glaucoma, conjunctivitis, eye pain, optic neuritis, otitis media.

Urinary tract inflammation, cystitis, menorrhagia.

Other: allergic reactions, difficulty living, abscess, neck pain, bacterial infections, cellular inflammation.

Rare, ADR

Cardiovascular: angina, coronary disorders, heart failure, myocardial infarction, venous inflammation, pulmonary embolism, exterior ventricular ventricular, ventricular tachycardia.

digestive: gastritis, vomiting blood, liver tumors, bowel obstruction, liver damage. blood: hemorrhage, thrombocytopenia, thrombocytopenia.

Metabolic: adrenal impairment, hyperglycemia, hypotension, hypoglycemia, hypoglycine reduction, respiratory acidic infection.

Central nerve: Memory loss, hemiplegia, neuropathy.

Respiratory: asthma.

Skin: peeling skin, herpes simplex, herpes zoster, skin cancer.

sensory: iritis, keratitis.

Urinary urinary: Albuminuria, glucose urinary, hematuria.

Other: cancer, birth defects, suicide intentions.

Instructions on how to handle ADR

To minimize the unwanted effect of the drug such as drowsiness, fatigue, dizziness, dry mouth, nausea, digestive disorders and hypotension, it is necessary to start with low doses and then increase to the effect of the user with tolerance. Rarely have to stop the drug. The illusion is all self -out, there is no manifestation of mental illness, and often occurs when used simultaneously with antidepressants.

Transaminase is temporarily increased, when stopping the drug will return to normal. Muscle weakness is sometimes notified but usually does not cause reduced muscle tone. Strict monitoring should be monitored on blood pressure before increasing the dose to avoid the risk of hypotension. Be cautious when changing a sudden posture from lying or sitting to a upright position.

For people with renal failure, it is necessary to closely monitor unwanted effects to avoid the risk of overdose and need to monitor the kidney function of drug users.

Notify the physician unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Waruwari drugs contraindicated in the following cases:

Hypersensitivity to the drug.

Severe liver failure.

Caution when used

on the cardiovascular system and blood pressure: The drug extends the QT range, causing slow heart rate. As well as α2 - Adrenergic -Adrenergic drugs, tizanidine can cause hypotension. Hypotension effect depends on the dose and appears after single -dose of 22 mg. When changing a sudden posture may increase the risk of hypotension.

tizanidine can cause liver damage, so it is very careful for people to impaired liver function. Aminotransferase should be monitored for the first 6 months of taking the drug (at the time of 1.3 and 6) and then periodically monitoring depends on the clinical condition. Tizanidin has a sedative effect, which can cause sleepiness to be cautious for people who need alertness such as driving, operating machinery ...

tizanidin can cause hallucinations on some drug users.

On the eyes: For experimental animals, medications that cause retinal degeneration and corneal opaque. However, there are no reports on these effects in clinical studies.

On people with renal failure: Use of caution for kidney failure with creatinine clearance

Elderly: Tizanidine only considers the benefits higher than the risk because on the elderly, the kidney clearance can be reduced four times.

Children: Experience using tizanidin for children under 18 years old is very limited. So do not use medicine for children.

to be out of reach of children.

The ability to drive and operate machinery

tizanidin has a small or medium influential effect on the ability to drive and operate machinery: Patients with drowsiness or dizziness or any signs or symptoms of lowering blood pressure should be recommended not to perform activities that require high alertness.

Pregnancy

tizanidin has not been studied on pregnancy. Should only use medication for pregnant people when really necessary.

The period of breastfeeding

has not yet been determined whether or not Tizanidin will be through breast milk or not. Tizanidine is soluble in lipids so it is likely that the drug can be through breast milk. Only use medication for breastfeeders when they have considered their benefits higher than risks.

Medicinal interaction

Medications that cause hypotension: tizanidin also lower blood pressure, so be cautious when used simultaneously with drugs that cause hypotension, including diuretics. Also be cautious when taking tizanidin along with β - adrenergic and digoxin inhibitors because of the risk of hypotension and slow heart rate.

Oral contraceptives: reducing the clearance of tizanidine by about 50%, increasing the unwanted effect of tizanidin.

Alcohol: Increases the area under the concentration - time (AUC) curve of tizanidine by about 20%, an increase of the peak concentration of about 15% thus increasing the unwanted effect of tizanidine. Tizanidine and wine inhibit the central nerve inhibitors.

Phenytoin: Tizanidine increases serum phenytoin concentration. When using these two medications simultaneously, it is recommended to monitor Phenytoin concentration to adjust the dose if necessary.

acetaminophen: tizanidin extends the time to reach the peak concentration of acetaminophen 16 minutes.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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