Xalgetz 0.4mg Getz drugs for signs of benign hypertension and syndrome (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Tamsulosin hydrochloride

Ingredient

Composition information	Content
Tamsulosin hydrochloride	0.4mg

Uses

Indications

Xalgetz TM 0.4 mg is indicated in the following case:

Treatment of benign hypertension and syndrome in the prostate (BPH).

These receptors are thought to be involved in the smooth muscle spasm of the prostate and bladder, resulting in increasing the flow rate of urine and reducing benign hypertension syndrome in the prostate. It also improves unstable bladder stimulation syndrome.

pharmacokinetic

absorption

tamsulosin HCl is absorbed almost completely through the gastrointestinal tract (> 90%) when hungry.

TMAX concentration (TMAX) reaches about 4 to 5 hours when hungry and 6 to 7 hours when taking medicine with food.

Use drugs when hungry stomachs increase by 30% bioavailability (AUC) and increase 40% to 70% of the peak concentration (CMAX) compared to when NO.

Distribution

tamsulosin HCl strongly connected to plasma proteins (94% to 99%), mainly with alpha - 1 glycoprotein (AAG), with wide variation. A small amount distributed into the brain, spinal cord and testes.

Metabolism

Slow metabolic drugs in the liver are largely due to cytochrome P450 enzymes. Most drugs are present in plasma in the form of unchanged.

Excretion

Medicines and metabolites are excreted mainly in urine, less than 10% of the dose is present in a constant form. After taking the prescription with the abdomen and the patient is in a stable state, the half -life is about 10 to 13 hours.

Before taking Xalgetz 0.4mg Getz drugs for signs of benign hypertension and syndrome (1 blister x 10 tablets)

How to use

Xalgetz drug is used orally. Should be used about half an hour after meals, at the same time of the day.

Dosage

Signs and proper hypertension syndrome in the prostate: Use 1 Xalgetz TM capsule 0.4 mg daily.

For patients who do not respond to the dose of 0.4 mg for 2-4 weeks, can increase to 2 xalgetztm 0.4 mg tablets (0.8 mg tamsulosin HCI) per day.

If stopped or interrupted for a few days at a dose of 0.4 or 0.8 mg, when used again, it must start with 0.4 mg daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Acute hypotension (70 mmHg systolic blood pressure), vomiting and diarrhea have been observed, can be indicated for infusion and patients should be removed from the same day. If acute hypotension occurs after an overdose, treatment is supporting the cardiovascular system, restoring blood pressure, regulating heart rate by holding patients in the back position. If this method is ineffective, it is possible to prescribe fluid, medications using vasoconstriction if necessary and closely monitor kidney function.

Do not separate because Tamsulosin is highly connected to plasma proteins.

Methods to prevent absorption, such as vomiting. When an overdose of a large amount of Tamsulosin HCl, the stomach can be washed or used as activated carbon and penetrated laxative like sodium sulphate.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The following side effects have been reported while using tamsulosin HCl:

Body: headache, infection, weakness, back pain, chest pain

sensory: blurred vision.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

tamsulosin HCl is contraindicated in the following patients:

Patients with hypersensitivity to Tamsulosin HCl or any ingredient of the drug.

Patients with a history of Hypotenary pressure .

Patients who are taking alpha - adrenergic inhibitors.

Patients with severe liver failure.

tamsulosin HCl is not specified:

Women.

Children.

Caution when using

like other Alpha 1 inhibitors, reducing blood pressure may occur during Tamsulosin HCl treatment in some patients, very rarely fainting. The initial signs of lower blood pressure (dizziness, fatigue), patients should sit or lie down until symptoms disappear.

Before the beginning of Tamsulosin HCl therapy, patients should check to eliminate other signs that may cause the same benign hypertension symptoms in the prostate. Rectal testing by technique and when necessary, determining the specific prostate antigen (PSA) should be tested before treatment and periodically.

There is no report on the use of drugs for patients with end -stage renal disease (creatinine clearance

Patients should be talked about the ability to erect penis pain when treating Tamsulosin and other similar drugs. Patients should be notified of this side effect rarely occur, but if not stopped immediately, it could lead to helplessness.

Mild iromic syndrome (ifis) has been observed in cataract surgery in several patients being treated or previously treated with Alpha 1 Adrenoceptor receptor.

The ability to drive and operate machinery

Patients treated with Tamsulosin HCl should be notified of some symptoms related to standing hypotension as stunned and should be cautious when driving or operating machinery.

Pregnancy

Contraindications.

Breastfeeding period

Contraindications.

Drug interaction

There is a pharmacokinetic interaction between cimetidine and tamsulosin HCl. The results showed significant changes in Tamsulosin HCl clearance system (down 26%) and AUC (up 44%). Therefore, caution should be used when combining Tamsulosin HCl with cimetidine, especially at a higher dosage than 0.4 mg.

Be cautious when using Warfarin and tamsulosin HCl.

tamsulosin HCl should be used carefully when combined with strong or mild CYP2D6 inhibitors (such as fluoxetine) or CYP3A4 (such as ketoconazole), especially at higher doses than 0.4 mg.

Storage

Leave a cool dry place, avoid light, avoid moisture, temperature below 30⁰C.

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