Xarelto 20mg Bayer prophylaxis of stroke and body embolism (1 blister x 14 tablets)

Dosage form Box of 1 blister x 14 tablets
Specifications Rivaroxaban

Ingredient

Composition information	Content
Rivaroxaban	20mg

Uses

indications

drug xarelto is indicated in the following cases:

Preventing stroke and body embolism in patients with atrial fibrillation without valve disease has a risk factor or more such as: Heart failure , Hypertension , age, diabetes, history of stroke or brain anemia. PE relapse.

Rivaroxaban is a highly selective direct inhibitor for a long -term element that has oral effects. The activation of factor X into a remote factor (FXA) through the endogenous and external pathway plays a central role in the blood clotting waterfall.

FXA directly converts prothrombin into thrombin through prothrombinase complex and finally, leading to fibrin blood clots and platelet activation by thrombin. A FXA molecule is capable of creating over 1,000 thrombin molecules due to the amplified nature of the blood clotting waterfall.

Pharmacological effects

The inhibition of a remote factor depends on the dosage.

Prothrombin time (PT), prothrombin time is partially activated (APTT) and Heptest are also prolonged dosage. No need to monitor blood coagulation parameters during treatment with Xarelto.

pharmacokinetics

absorption and bioavailability

Rivaroxaban absorbs oral and oral bioavailability (80-100%). Maximum concentration (cmax) after 2-4 hours of medication.

distribution

Conducting protein in plasma is approximately 92% to 95%. VSS distribution volume is about 50L.

metabolism and elimination

Rivaroxaban is metabolized through CYP 3A4, CYP 202 mechanisms and non -dependent CYP mechanisms. Selling time is about 5-9 hours in young people and about 11-13 hours in the elderly.

Before taking Xarelto 20mg Bayer prophylaxis of stroke and body embolism (1 blister x 14 tablets)

How to use

use orally, should be taken with food.

can grind Xarelto 20mg and mix with water or soft food like apple juice right before use and be used by oral. After taking Xarelto tablets, it should be followed immediately with food.

The crushed Xarelto tablet can be given through the gastric catheter, the crushed drug must be used with a small amount of water through the gastric catheter and then added water. After taking Xarelto tablet is crushed, it should be followed immediately with feeding through the intestinal tract.

Dosage

Prevention of stroke and body embolism in patients with atrial fibrillation (Spaf)

recommended dose is every 20 mg every day

Treatment and prevent relapse DVT and PE

Day 1 to 21: dose 15 mg 2 times/day, maximum 30 mg/day. Xarelto

For patients with prophylaxis of stroke and body embolism, should stop treating VKA and start with Xarelto when the Inr

In patients who move from Xarelto to VKA, should use Xarelto and VKA at the same time until the Inr 2.20 index. In the first two days of the drug conversion phase, VKA dose adjusted according to Test Inr used after the standard dose of VKA.

Stop using anticoagulants and should start taking Xarelto 2 hours before the next use of the injection or at the time of stopping intravenous drugs.

Transferring from Xarelto to anticoagulant drugs

Stop taking Xarelto 20mg and start the first dose of anticoagulant drugs at the time of the next xarelto dose.

Special subjects

Renal failure: Patients with average renal impairment (Creatinine clearance (CrCl) 30-49 ml/minute) or severe (CrCl 15-29 ml/minute):

In stroke prevention and body embolism in patients with atrial fibrillation due to heart valve (spaf), recommended dose is 15 mg once a day. 15 mg twice a day for the first 3 weeks. Then, when the recommended dose is 20 mg once a day, it is advisable to consider reducing the dose every 20 mg once a day to 15 mg on a day if the risk of bleeding is considered to be more than the risk of relapse DVT and PE. Skin rims) with stent:

Patients with atrial fibrillation due to heart valve disease, those who are performed PCI have stent should be used for 15 mg of xarelto once a day (or 10 mg xarelto once daily for patients with average renal insufficiency [CrCl: What to do when overdose?

There is no specific detoxification substance against pharmacological effects of rivaroxaban .

Bleeding management:

In patients with Rivaroxaban if a bleeding complication occurs, the next dose of treatment should be temporarily suspended or stopped completely if appropriate, using symptomatic treatments if necessary.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Xarelto 20mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Blood disorders, hematology: Anemia ;

Eyes: Eye bleeding;

Gastrointestinal disorders: gum bleeding, gastrointestinal bleeding, abdominal pain, indigestion, nausea, constipation , diarrhea, vomiting;

Disorders in Chi: pain in Chi;

Damage, toxicity, postoperative complications: postoperative bleeding, stamping;

Neurology: headache , dizziness;

Other disorders: fever, peripheral edema, decreased strength, general energy, nosebleeds, itching, skin hemorrhage, skin hematoma, ...

Uncommon, 1/1000

Blood disorders, hematology: platelet increase;

On the heart: tachycardia;

Gastrointestinal disorders: dry mouth ;

Lesion, toxicity, postoperative complications: secretion of secretion;

Neurology: brain bleeding and endoscopy, fainting;

Disorders in limb: joint hematoma;

Other disorders: discomfort, reduced liver function, urticaria, ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Xarelto medicine 20mg contraindicated in the following cases:

Patients with hypersensitivity to rivaroxaban or any ingredients of the drug.

Patients with clinical bleeding (such as intracranial bleeding, gastrointestinal bleeding).

Patients are being treated with other anticoagulants, except for specific cases during the transition from one anticoagulant to another anticoagulant or when heparin is not segmented to maintain the opening of the artery or central vein.

Patients with liver disease are associated with coagulation disorders and the risk of clinical bleeding, including patients with cirrhosis with Child Pugh B and C.

Contraindicated Xareto in pregnant women and during breastfeeding.

Caution when using

Hemorrhage risk

Recommendations should be used carefully in diseases that increase the risk of bleeding:

congenital or suffering bleeding disorders;

vascular abnormalities in the spinal or brain;

Should stop treatment with Xarelto at least 24 hours before the intervention if possible and based on the clinical assessment of the doctors.

Neurological anesthesia (external/spinal cord): When anesthesia nerves or spinal cord detection, patients should be treated with anti -thrombotic drugs. Remove pulmonary obstruction, patients who are performed PCI have stent.

The ability to drive and operate machinery

There have been reports on cases of fainting and dizziness and can affect the ability to drive and operate machinery. Patients encountering these harmful reactions should not drive or use machines.

Pregnancy

Contraindicated Xarelto in pregnant women.

Breastfeeding period

xarelto 20mg contraindicated during breastfeeding time.

Drug interaction

pharmacokinetic interaction

It is not recommended to use xarelto simultaneously with antifungal drugs Azole using systemic sugar such as ketoconazole, iTraconazole, Voriconazole and Posaconazole or HIV protease inhibitors. Phenytoin, carbamazepin , phenobarbitone or St. John's Wort may also lead to reduced rivaroxaban levels in plasma.

Pharmacological interaction

Pay attention to the patient if treated simultaneously with any other drug -related drugs: Enoxaparin, NSAIDs, platelet collection inhibitors, warfarin, ...

Food and dairy food: Xarelto 20mg tablets can be taken with food.

Storage

Do not leave the drug at a temperature of over 300C.

Bayer Pharma Company

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.