Xatral XL 10mg Treatment of symptoms of hypertrophy (1 blister x 30 tablets)

Dosage form Box of 1 blister x 30 tablets
Specifications Alfuzosin

Ingredient

Composition information	Content
Alfuzosin	10mg

Uses

indications

XL 10mg XL drug is indicated in the following cases:

Treatment of functional symptoms of hypertrophy (increasing volume) benign prostate.

Auxiliary treatment in the case of urinary retention must put urinary tract due to benign prostatic hypertrophy.

Pharmacokic

alfuzosin is a derivative of Quinazoline that works when used orally and is a selective antagonistic Synapse on Alpha-1 Adrenergic receptor. In vitro pharmacological research confirms the selection of alfuzosin on Alpha-1 adrenergic receptors at the prostate, bladder triangle and urethra.

Through the direct effect on the smooth muscle of the prostate tissue, alpha blockers reduce the blockage of the bladder. Research in vivo in animals shows that alfuzosin reduces urethral pressure and thus reduces the resistance on the urinary urinary tract.

Mouse research is also aware that the impact of the drug on urethra pressure is more than on blood pressure. From control studies with placebo on patients with benign prostatic hypertrophy, alfuzosin:

Increase the significance of the flow rate with an average ratio of 30% in a group of patients with current urinary speed ≤ 15 ml/second. This improvement is recorded from the first dose.

Means the significance of the bladder sphincter pressure and increases the volume, thus restoring the feeling of urination.

Meaningfully reduced the volume of urine.

These effects help improve irritant symptoms and congestion of urinary tract. Alfuzosin does not affect sexual function.

Moreover, the maximum urinary speed still significantly has the meaning of 24 hours after taking the drug.

pharmacokinetics

absorption (slow release form):

The average of bioavailability reaches 104.4% after using a dose of 10 mg, when compared to the instant release, the dose of 7.5 mg (2.5 mg x 3 times/day), in healthy middle -aged volunteers.

Peak concentration in plasma reaches 9 hours after drinking compared to 1 hour for instant release. Many studies show that the bioavailability of the drug increases when used after meals.

Distribution:

The ratio of plasma protein binding is about 90%.

Metabolism:

alfuzosin metabolizes mostly in the liver.

Era:

The drug excreted through the kidney is only 11% in the form of a compound not changed. Most metabolic components (inactive) are discharged through feces (75–90%). The sale time is 9.1 hours (for slow release).

Alfuzosin's pharmacokinetic properties do not change in the case of chronic heart failure.

Before taking Xatral XL 10mg Treatment of symptoms of hypertrophy (1 blister x 30 tablets)

How to use

Xatral XL 10mg drug used orally. Take medicine right after dinner.

must swallow the tablet with a glass of water. Do not bite, chew, crush or grind into powder.

In case there is a catheter, it is advisable to take the drug from the first day of the pipe and treatment with the drug for 3 to 4 days, that is, taking the drug during the time of the urinary catheter for 2 to 3 days and 1 day after the catheterization.

If you feel that the effect of Xatral XL 10mg The prolonged release tablet is too strong or too weak, notify the doctor or pharmacist.

Dosage

1 tablet/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In case of overdose, patients need to be taken to the hospital in a lying position. Hematopsy should be set out. Due to the ability to cohesive with high protein, alfuzosin is very difficult to be separated.

What to do when forgetting 1 dose?

Side Effects

When using Xatral XL 10mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurology: dizziness, dizziness, discomfort, headache;

digestive: nausea, abdominal pain;

Systemic: Feeling tired, weak.

Uncommon, 1/1000

Neurology: Feeling dizziness, sleeping chicken;

Cardiovascular: Hypotension when switching from a posture to a standing position, increasing heart rate, brushing chest drum, fainting, blushing, edema, chest pain;

Digestive: diarrhea, dry mouth;

Respiratory: stuffy nose;

Skin: skin allergies like lumpy or itching.

Very rare, ADR

Cardiovascular: angina in patients with a history of coronary artery disease.

skin: urticaria.

Not determined frequency

liver: liver damage, cholestatic hepatitis.

Genital: Penis penis lasts.

Instructions on how to handle ADR

When experiencing side effects of Xatral XL 10mg, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Xatral XL 10mg drug is contraindicated in the following cases:

allergies to alfuzosin and/or one of the ingredients of the drug;

Hypotension posture (feeling dizziness often appears when changing from posture lying to stand up);

Liver function (liver failure);

Severe renal function;

Combining drugs with Ritonavir.

Be cautious when using

Some people are particularly sensitive to Xatral XL 10mg manifested by hypotension when moving from a lying position to stand up. This phenomenon may appear in the first few hours after taking the drug, accompanied by the following symptoms: dizziness, fatigue, sweat. If this case occurs, the patient should be placed in a lying position until these temporary symptoms completely disappear.

Soft iris syndrome in surgery (ifis): If you are planning to surgery for cataract surgery (dry bead) in the near future and if you have or are using Xatral XL 10mg, notify your doctor before surgery. This drug can cause side effects and lead to complications during surgery. However, if notified, depending on the treatment process, the doctor will have to be cautious at surgery.

Be cautious when using alfuzosin for the elderly and patients with significant hypotension after taking other Alpha-1 blockers.

For patients with coronary artery disease, alfuzosin should not be indicated. Need to continue treating coronary insufficiency. In the case of angina worse or recurrent, alfuzosin should be discontinued.

Patients need to be notified of swallowing pills. Do not bite, chew, crush or grind into powder. These movements will make the release and absorption of inappropriate drugs lead to unwanted effects that can start sooner.

The ability to drive and operate machinery

It should be noted to those who operate machinery and trains about the risk of posture lowering the posture (hypotension when moving to a standing posture, sometimes accompanied by dizziness), feeling dizziness, fatigue or visual disorders, especially when starting treatment.

Pregnancy

drugs are not for women. Consult your doctor or pharmacist before taking any medication.

breastfeeding period

Xatral XL 10mg is not for women. Consult your doctor or pharmacist before taking any medication.

Drug interaction

does not combine alfuzosin with ritonavir because ritonavir increases allfuzosin concentration in plasma and increases unwanted effects.

Combining non -recommended drugs:

Alpha blockers treat hypertension (prazosin, trimazosin, urapidil) increase the effectiveness of hypotension. The risk of severe posture hypotension.

Ketoconazole, Itraconazole, Clarithromycin, erythromycin increases the concentration of alfuzosin in plasma and increases unwanted effects.

Combining the drug should be cautious: Phosphodiesterase type 5 inhibitors (Sildenafil, Tadalafil, Vardenafil) increase the risk of posture lowering posture, especially in the elderly.

Combining drugs to consider:

Medications for hypertension except Alpha blockers increases the effectiveness of hypotension. Increased risk of posture hypotension.

nitrates, nitrites and related drugs (isosorbide dinitrate, isosorbide, lisidomine, molsidomine, nicorandil, nitroglycerine) increase the risk of hypotension, especially posture hypotension.

Storage

Store drugs at a temperature not exceeding 30ºC.

Leave the medicine out of children's vision and reach.

Do not use the drug beyond the expiry date with the outside of the drug box.

Do not remove cigarettes in wastewater or household waste bins. Ask the pharmacist how to cancel these unused drugs. This will help protect the environment.

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