Xilavic 625mg Micro Micro Treatment of severe respiratory infections (10 tablets)

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family that has a broad bactericidal spectrum for many Gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cell walls. But because Amoxicillin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (multiple enzymacteriaceae and Haemophilus influenzae).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicillin, has the ability to inhibit beta - lactamase due to the majority of gram -negative bacteria and staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillin and cephalosporin.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some Entobacter strains and providentia anti -drugs, staphylococcus anti -methicillin staphylococcus also. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps Amoxicillin not be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resist other penicillins and cephalosporins.

It is possible to see Amoxicillin and Clavulanate are bactericidal for pneumococcus, streptococcus beta beta, staphylococcus (sensitive strain with penicillin is not affected by penicillinase), Haemophilus Influenzae and Branhamella Catatrhalis, including strong products lactamase.

In summary, the antibacterial spectrum of the drug includes:

Gram -positive bacteria

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, Pasteurae Multocida.

Anaerobic type: Baceroides including B. Fragilis.

pharmacokinetics

After drinking, amoxicillin and potassium clavulanate absorb good through the gastrointestinal tract. The safety and activity of amoxicillin, potassium clavulanate has been determined in clinical trials that Amoxicillin and Potassium Clavulanate are driven away from meals. Amoxicillin diffuses easily into most tissues and fluid in the body, except for brain tissue and cerebrospinal fluid.

In vivo, clavulanic acid and amoxicillin quickly distributed into the tissues in the body. After taking 500 + 125mg amoxicillin + potassium clavulanate tablets, about 50 - 70% amoxicillin and nearly 25 - 40% of Clavulanic acid excreted raw format within the first 6 hours. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid through the kidney.

Be cautious when using

Before treatment with amoxicillin/acid clavulanic, need to be cautious about the patient's hypersensitivity with penicillin, cephalosporin or other Lactam - lactam drugs.

Serious and life -threatening hypersensitivity reactions (anaphylactic shock) have been reported in patients using penicillin. These reactions can occur in patients with a history of allergies to penicillin or in allergy patients. If the allergic reaction occurs, amoxicillin/clavulanic acid must be stopped immediately and replaced by other appropriate therapy.

In case of an infection that is shown to respond to amoxicillin, it is possible to consider changing the use of amoxicillin/clavulanic acid to the use of a single amoxicillin with the guidance of a doctor.

Seism can occur in patients with renal failure or patients with high doses.

amoxicillin/clavulanic acid should be avoided for patients who suspect mononuclear hypertension because the measles rash is related to the disease after taking amoxicillin.

Simultaneous use of Allopurinol during amoxicillin may increase skin allergies.

For prolonged use can sometimes cause excessive growth of uncertainty bacteria.

Be careful to use amoxicillin/clavulanic acid for patients with liver failure.

Liver diseases have been reported in men and the elderly and may be involved in prolonged medication. These cases are rarely reported in children.

Antibiotic -related inflammation has been reported to most antibiotics and the level of mild to life -threatening. Therefore, be careful in diagnosis when patients have diarrhea while or after antibiotics. When colitis occurs, it is necessary to stop using amoxicillin/clavulanic acid and replace it with another appropriate treatment.

Periodic assessment of organs including kidneys, liver and hematopoietic function is recommended for prolonged medication.

Prothrombin is rarely reported in patients using amoxicillin/clavulanic acid. Strict monitoring must be monitored when prescribing anticoagulants for patients taking amoxicillin/clavulanic acid. Adjusting the oral dosage of anticoagulants may be necessary to maintain anticoagulants in the blood.

In patients with renal failure, the dose should be adjusted according to the degree of renal failure.

While taking amoxicillin high doses, drinking enough water to reduce the possibility of the urinary crystal appearance. In patients using bladder catheter, it is necessary to monitor more closely.

The ability to drive and operate machinery

does not affect.

Pregnancy

There are no complete and well -controlled studies in pregnant women. Because animal studies do not always correspond to humans, only amoxicillin - potassium clavulanate during pregnancy when really necessary.

Breastfeeding period

Ampicillin antibiotics are excreted in milk, so be careful when using amoxicillin - potassium clavulanate in nursing women.

Medicinal interaction

simultaneous use of methotrexate and penicillin can reduce methotrexate excretion, increased toxicity.

Probenecid reduces amoxicillin secretion through the renal tubules. Simultaneous use of probenecid with amoxicillin - potassium clavulanate can increase the concentration of amoxicillin and extend the time of existence in the blood. Amoxicillin - potassium clavulanate can reduce the effectiveness of oral contraceptives. It should be taken into account the ability to prolong blood clots in patients with simultaneous use amoxicillin - potassium clavulanate with anticoagulant drugs.

In patients with Mycophenolate Mofetil, a report reduces the concentration of metabolic metabolites with mycophenolic acid activity (MPA) to 50% after starting to drink amoxicillin/ clavulanic acid. The change of drug concentration at the first dose may not represent the exact change for the overall change of MPA. Therefore, adjusting the dose of mycophenolate mofetil should be very careful based on the whole process of drug use.