Xonatrix 60mg Davipharm Treatment Symptomatic Symptoms of Holitis (3 Blister X 10 Tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Fexofenadine
Indication Rhinitis, allergic rhinitis, urticaria, itching, stuffy nose

Ingredient

Composition information	Content
Fexofenadine	60mg

Uses

indications

Xonatrix drug is indicated in case of:

Treatment of symptoms in allergic rhinitis season, chronic urticaria in adults and children over 6 years old.

ATC code: R06AX26.

Fexofenadin is a second -generation antihistamine drug, with specific antagonistic and selective effects on peripheral H1 receptors.

The drug is a metabolic substance of terfenadin, also competing with histamine at H1 receptors in the digestive tract, blood vessels and respiratory tract, but no toxicity for the heart due to not inhibiting potassium channels associated with myocardial cycle.

Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no effect of inhibiting receptors of Alpha, or Beta - Adrenergic.

In the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

Dynamic pharmacokinetics

Good absorbing drugs when taken orally and starting to work after 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (to about 4 hours). Anti -antihistamine effect lasts more than 12 hours.

The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha1 - Glycoprotein acid. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Fexofenadin is very smaller (about 5%, mainly in the intestinal mucosa. Only about 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances). About 3.5% of fexofenadin dose metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives.

This metabolite is only seen in the feces, so there may be the participation of intestinal bacteria in this metabolism. Fexofenadin waste time is about 14.4 hours, longer (31 - 72%) in kidney failure.

Mainly eliminated drugs (approximately 80%) and urine (11 - 12%) in constant form.

Dynamic pharmacokinetics in people with renal failure

CICR 41 - 48 ml/minute: The peak concentration is higher than 87%, the selling time is longer than 59%. Strong.

Before taking Xonatrix 60mg Davipharm Treatment Symptomatic Symptoms of Holitis (3 Blister X 10 Tablets)

How to use

Xonatrix taken orally, do not drink with fruit juice. The time to take the drug does not depend on the meal, but not to drink too close (for 15 minutes) with antacids containing magnesi and aluminum.

Dosage

Allergic rhinitis

The usual dosage to treat symptoms for adults and children over 12 years old is 60 mg x 2 times/day or 180 mg, oral 1 time/day.

Children under 12 years old

Daceller form is not suitable for the designated dose.

The usual dosage for adults and children aged 12 and older is 60 mg x 2 times/day or 180 mg, oral 1 time/day.

Children under 12 years old

Daceller form is not suitable for the designated dose.

Children 12 years and older and adults with renal failure, the elderly: Start using the dose of 60 mg oral 1 time/day, adjust the dose according to the renal function. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Using conventional measures to remove the drug that has not been absorbed in the digestive tract. Support support and treatment.

Hemolysis reduces the concentration of drugs in the blood (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Unwanted effects (ADR) when using xonatrix that you may encounter.

Common, ADR> 1/100

Neurological: Drowsy, tired, headache , insomnia, dizziness.

digestive: nausea, indigestion.

Other: prone to viral infection (colds, flu), abdominal pain during menstruation, susceptible to upper respiratory infections, itchy throat, cough, fever, otitis media, sinusitis, back pain.

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares.

digestion: dry mouth, abdominal pain. all body: tired.

Rare, 1/10000 ≤ ADR

Skin: Ban, urticaria, itching.

Hypersensitivity reactions: Evana, chest tightness, shortness of breath, redness, anaphylaxis.

Unknown frequency

Cardiovascular: tachycardia, chest drum.

digestive: diarrhea.

Instructions on how to handle ADR

ADR of the drug is usually mild, only 2.2% of patients have to stop the drug due to the ADR of the drug. When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Xonatrix contraindicated in the following cases:

Hypersensitivity to fexofenadin, terfenadin, or any ingredients of the drug.

Be cautious when used

Be careful and adjust the appropriate dose when taking drugs for people with impaired renal function because the concentration of drugs in plasma increases due to prolonged semi -exhaust time. Be careful when taking medicine for the elderly (over 65 years old) often has a decline in kidney physiology.

Safety and effectiveness of drugs in children under 6 months of age has not been identified.

Need to stop Fexofenadin at least 24 - 48 hours before conducting injection antigen tests.

Use fexofenadin to make psoriasis worse.

Antihistamine drugs can cause unwanted effects: Heart beating fast, brushing chest drums. Precautions for people with a history or cardiovascular disease.

Xonatrix contains lactose monohydrates, patients with galactose tolerance disorders, lagl lactase deficiency or glucose - galactose absorption disorders should not be used.

The ability to drive and operate machinery

Although Fexofenadin is less likely to be drowsiness, but still need to be cautious when driving or controlling machines requires alert.

Pregnancy

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the benefit of the mother is superior to the risk of the fetus.

The period of breastfeeding

It is unclear whether the drug is excreted in milk or not, although it has not seen the unwanted effect in newborn babies when breastfeeding mothers use fexofenadin, so be careful when using fexofenadin for breastfeeding women.

Drug interaction

Fexofenadin does not metabolize through the liver so there is no interaction with other drugs metabolized through the liver.

erythromycin and ketoconazole increase fexofenadin levels in plasma but do not change the QT range.

Fexofenadin concentration may be increased by erythromycin, ketoconazole, verapamil, p - glycoprotein inhibitors.

There is no interaction between fexofenadin and omeprazol. Do not simultaneously use fexofenadin with antacids containing aluminum, magnesi because it will reduce the absorption of fexofenadin. Fexofenadin may increase alcohol content, central nervous sedatives, cholinergic anti -choliners.

Fexofenadin may reduce the concentration of acetylcholininininiserase inhibitors (in the central nervous system), Betahistin.

Fexofenadin may be reduced by concentrations by acetylcholinininininiserase inhibitors (central nervous system), amphetamine, acid resistant, grapefruit juice, rifampin.

Fruit juice (oranges, grapefruit, apples) can reduce the bioavailability of fexofenadin by 36%. Avoid using fexofenadin with ethylic alcohol (alcohol) because it increases the risk of sedation (sleep).

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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