Xonatrix Forte 180mg Davipharm Treatment Symptomatic Symptoms of allergic rhinitis (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Fexofenadine
Indication Rhinitis, allergic rhinitis, sinusitis, itching, contact dermatitis

Ingredient

Composition information	Content
Fexofenadine	180mg

Uses

indicated

xonatrix Forte is indicated in the following cases:

Treatment of symptoms in allergic rhinitis season, chronic urticaria in adults and children over 6 years old.

ATC code: Ronax26.

Fexofenadin is a second -generation antihistamine, which has a specific antagonistic and selective effect on peripheral H1 receptors. The drug is a metabolic substance that has the activity of terfenadin, also competing with histamines at H1 receptors in the digestive tract, blood vessels and respiratory tract, but no toxicity for the heart due to not inhibiting potassium channels related to myocardial cycles. Fexofenadin has no significant effects on acetylcholin, dopamine antagonism and has no effect on inhibiting alpha, or beta - adrenergic receptors. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into receptors H, forming a sustainable complex and separating slowly.

Dynamic pharmacokinetics

Good absorbing drugs when taken orally and starting to work after 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (to about 4 hours). The antihistamine effect lasts more than 12 hours. The associated ratio of plasma proteins of the drug is 60 - 70%, mainly with albumin and alpha1 -acid glycoprotein.

It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin as a metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier. Fexofenadin is very little metabolized (about 5%, mainly in the intestinal mucosa. Only about 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances).

About 3.5% of the dose of fexofenadin metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives. This metabolite is only seen in the stool, so there may be the participation of intestinal bacteria into this metabolism. Fexofenadin's exhaust time is about 14.4 hours, lasting longer (31 - 72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11 - 12%) in constant form.

kidney failure

CLCR 41 - 48 m/minute: The peak concentration is 87%higher, the sale time is longer than 59%.

CLCR 11 - 40 m/minute: The peak concentration is 111%, the sale time is 72%longer. CLCR

Elimination with ineffective blood decomposition.

Before taking Xonatrix Forte 180mg Davipharm Treatment Symptomatic Symptoms of allergic rhinitis (10 blisters x 10 tablets)

How to use

Xonatrix Forte torture. Do not drink with fruit juice. The time to take the drug does not depend on the meal, but not to drink too close (for 15 minutes) with antacids containing magnesi and aluminum.

Dosage

Allergic rhinitis

The usual dosage to treat symptoms for adults and children over 12 years old is 60 mg 2 times/day or 180 mg, oral 1 time/day.

Children under 12 years of age: The formation is not suitable for the designated dose.

Standing chronic urticaria

The usual dose for adults and children aged 12 and older is 60 mg 2 times/day or 180 mg, oral 1 time/day.

Children under 12 years of age: The formation is not suitable for the designated dose.

Elderly and kidney failure

Children aged 12 years and older and adults with renal failure, the elderly: Start using 60 mg orally 1 time/day, adjust the dose by kidney function.

Children under 12 years of age: The form of preparation does not match the specified dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Management:

Use conventional measures to eliminate the drug that has not been absorbed in the gastrointestinal tract.

Supporting and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Xonatrix Forte , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Drowsy, tired, headache, insomnia, dizziness.

digestive: nausea, indigestion.

ENT: Salted to be infected with viruses (colds, flu), susceptible to upper respiratory infections, itchy throat, cough, otitis media, sinusitis.

body: Fever, back pain. genital: abdominal pain during menstruation.

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares.

digestive: dry mouth , abdominal pain. all body: tired.

Rare, 1/1000

Skin: Ban, urticaria, itching.

Systemic body: Fengbo, chest tightness, shortness of breath, redness, anaphylaxis.

Unknown frequency:

Cardiovascular: tachycardia, chest drum.

digestive: diarrhea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Xonatrix Forte contraindicated in the following cases:

Hypersensitivity to fexofenadin, terfenadin, or any ingredients of the drug.

Be cautious when used

Be careful and adjust the appropriate dose when taking drugs for people with impaired renal function because the concentration of drugs in plasma increases due to prolonged semi -exhaust time.

Be careful when taking medicine for the elderly (over 65 years old) often has a physiological impairment of kidney function.

Safety and effectiveness of drugs in children under 6 months of age has not been identified.

It is necessary to stop Fexofenadin at least 24 - 48 hours before conducting injections in the skin.

Use Fexofenadin to make psoriasis.

Using drugs for the elderly (over 65 years old) often has impaired renal physiology.

Safety and effectiveness of drugs in children under 6 months of age have not been identified.

It is necessary to stop Fexofenadin at least 24 - 48 hours before conducting injections in the skin.

Antihistamine drugs can cause unwanted effects: Heart beating fast, brushing chest drums.

Be cautious for people with a history or have cardiovascular disease.

Xonatrix contains lactose monohydrate, patients with galactose tolerance disorders, lactase deficiency or glucose - galactose absorption disorders should not be used.

The ability to drive and operate machinery

Although Fexofenadin is less likely to be drowsiness, but still need to be cautious when driving or controlling machines requires alert.

Pregnancy

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the benefit of the mother is superior to the risk of the fetus.

The period of breastfeeding

It is unclear whether the drug is excreted in milk or not, although it has not seen the unwanted effect in newborn babies when breastfeeding mothers use fexofenadin, so be careful when using fexofenadin for breastfeeding women.

Drug interaction

Fexofenadin does not metabolize through the liver so there is no interaction with other drugs metabolized through the liver.

erythromycin and ketoconazole increase fexofenadin levels in plasma but do not change the QT range.

Fexofenadin concentration may be increased by erythromycin, ketoconazole, verapamil, p - glycoprotein inhibitors.

There is no interaction between fexofenadin and omeprazol. Do not simultaneously use fexofenadin with antacids containing aluminum, magnesi because it will reduce the absorption of fexofenadin.

Fexofenadin may increase alcohol content, central nervous sedatives, cholinergic substances.

Fexofenadin may reduce the concentration of acetylcholininininiserase inhibitors (in the central nervous system), Betahistin.

Fexofenadin may be reduced by concentrations by acetylcholininininiserase inhibitors, amphetamine, acid resistant, grapefruit juice, rifampin.

Fruit juice (oranges, grapefruit, apples) can reduce the bioavailability of fexofenadin by 36%.

Avoid using fexofenadin with ethylic alcohol (alcohol) because of increasing the risk of sedation (sleep).

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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