Yesom 40 Heterero Treatment of Gastrointestinal ulcer - benign duodenum (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Esomeprazol

Ingredient

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Composition information	Content
Esomeprazol	40mg

Uses

indications

Yesom 40 drugs are indicated in the following cases:

Gastric ulcer - benign duodenum.

Zollinger -Elison syndrome. Learning

Esomeprazol is the S isomers of omeprazol, used similarly to Omeprazol in the treatment of gastric ulcer and gastroesophageal reflux disease.

Esomeprazol is attached to H+/K+ - ATPase (also known as proton pump) in the stomach cell, inhibiting this enzyme system, preventing the final step of the excretion of acidic into the stomach. So Esomeprazol has the effect of inhibiting the basic acid secretion and even when stimulated by any agent.

Dynamic pharmacokinetics

Esomeprazol absorbed quickly after oral, reaching the highest concentration in plasma after 1-2 hours. Esomeprazol's bioavailability increases according to the dose and when used to repeat, reaching about 68% when taking the dose of 20 mg and 98% when taking the dose of 40 mg.

Food slows down and reduces the absorption of Esomeprazol. Esomeprazol is associated with 97% with plasma proteins. The drug is mainly metabolized in the liver thanks to isenzy CYP2C19, the cytochrom peso enzyme system into hydroxyl and desmethyl metabolites is no longer active. Half life eliminated in plasma 1 - 1.5 hours. About 80% of oral doses are eliminated in the form of non -active metabolites in the urine, the rest is eliminated in feces.

Before taking Yesom 40 Heterero Treatment of Gastrointestinal ulcer - benign duodenum (3 blisters x 10 tablets)

How to use

must swallow both follicles, not crushed or chewed. However, if the patient is difficult to swallow, the capsule can be poured slowly inside the follicles into a tablespoon of boiled water to cool, or apple juice, orange juice and drink immediately. Take medicine at least 1 hour before meals.

Dosage

Treatment of gastric ulcer has Helicobacter pylori:

Esomeprazol is a component in the treatment regimen along with antibiotics, for example 3 drug regimen (along with amoxicillin and clarithromycin). Take Esomeprazol at 20mg, twice a day for 7 days, or 40 mg once a day for 10 days (amoxicillin each time 1.0g twice a day and Clarithromycin each time 500mg 2 times a day for 7 days or 10 days).

Treatment of gastroesophageal reflux disease with esophagitis:

Take it once a day 20 - 40 mg for 4 - 8 weeks, can take 4-8 weeks for more if there is still symptoms or manifestations of laparoscopic inflammation.

Maintenance treatment after gustary inflammation:

Take it once a day, 20 mg each time, can last up to 6 months.

Preventive gastric ulceration in people with high risk of stomach complications, but there is a requirement to continue treatment with nonsteroidal anti-inflammatory drugs:

Take oral once a day 20 mg.

Treatment of gastroesophageal reflux symptoms but no esophagitis:

Take 1 time 20 mg per day for 4 weeks, can take 4 more weeks if the symptoms are not completely cured.

Treatment of stomach ulcers due to nonsteroidal anti -inflammatory drugs:

Take every day 20 mg for 4 to 8 weeks.

Treatment of Zollinger-Eleson syndrome:

Depending on the individual and the level of acid secretion of the gastric juice, the daily dose is higher daily in other cases, once used or divided into 2 times a day. When symptoms are controlled, surgery may be used to cut tumors. If the tumor is not completely removed, the medication must be used for a long time.

Severe liver failure does not use more than 20 mg a day. There is no need to reduce the dose in mild and medium liver failure people, kidney or elderly people. Do not take medicine for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Because Esomeprazol is attached to a large part of protein, it may not be removed by the cup. In case of overdose, symptomatic treatment and support.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Yesom 40, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: headache, dizziness, skin extra skin.

Body: fatigue, insomnia, drowsiness, rash, itching, visual disorders.

Body: Fever, sweat, peripheral edema, sensitivity to light, hypersensitivity reactions (including urticaria, angioedema, bronchospasm, anaphylaxis). Liver, hepatitis, jaundice, liver function.

digestive gastrointestinal disorders

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Yesom 40 contraindications in the following cases:

Esomeprazol is contraindicated in patients with hypersensitivity to any ingredients of the preparation or with replacement benzimidazols.

Caution when used

Before taking proton pump inhibitors, it is necessary to eliminate the possibility of stomach cancer because the drug can cover symptoms, slow down the cancer guess.

Be cautious when used in people with liver disease, pregnant or lactating. Precautions must be used when using Esomeprazol for prolonged because it can cause gastritis.

Be cautious when used for children under 18 years of age because of safety and effectiveness.

The drug is not recommended for children.

It is recommended not to use Esomeprazol simultaneously with Atazanavir. If it is necessary to simultaneously use Atazanavir with proton pump inhibitors, it is necessary to carefully monitor clinical and increase the dose of Atazanavir to 400 mg along with 100 mg of ritonavir; Do not use more than 20mg of esomeprazol.

Slow release of Esomeprazol Magnesi contains sucrose. Patients with rare genetic problems in fructose tolerance, poor absorption of glucose-galactose or deficiency of sucrose-isomaltase should not use this drug.

The ability to drive and operate machinery

Patients should note that the drug may cause headaches, dizziness and drowsiness.

Pregnancy

There is no adequate and well -verified research in pregnant women.

Has received sporadic reports on unusual things that occur in young children born from women who used omeprazol during pregnancy.

Lactation period

Because Esomeprazol can be excreted in human milk, because the possibility of serious unwanted effects in young children breastfeeding caused by Esomeprazol, and because the ability to cause tumors has been proven to Omeprazol in studies on cancer effects on white rats, will have to stop nursing or stop drug use, consider important drugs for people Mom.

Interactive drug

Patients treated with proton and warfarin pump inhibitors and may need to be monitored for increase in Inr and prothrombin time.

Esomeprazol may have an influence on CYP2C19, which is the main enzyme metabolism of Esomeprazol.

Concomitance the use of Esomeprazol 30 mg and Diazepam, a substrate of CYP2C19, resulting in a 45% reduction in Diazepam's clearance.

Combined with Clarithromycin: Concomplified use of ecomeprazol, clarithromycin and amoxicillin has led to an increase in plasma concentrations of ecomeprazol and 14-hydroxy-clarithromycin.

Storage

Store less than 30 ° C, avoid moisture. Leave the medicine out of the reach of children.

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