Zensalbu 2.5mg CPC1HN medicine controls chronic bronchospasm, acute severe asthma treatment (2 blisters x 5 tubes)

ATC code: RO3CC02

Salbutamol has a selective effect to stimulate the beta2 receptor receptor (found in bronchial muscles, uterine muscles, blood vessel smooth muscles) increase the synthesis of ampv, dilate the bronchial smooth muscle, uterus, blood vessels; Stimulating muscle pattern and less effect on the Betal adrenergic receptor on the heart muscle is less effective on the heart.

Smooth muscle relaxation effect depends on the dose and is said to occur through the adenyl cyclase-amp system, with the drug attached to the beta-2-adrenergic receptor in the cell membrane causing ATP transformation into amp to activate protein kinase. This leads to phosphorylation of proteins and eventually increases linked calcium intracellular calcium; The ionized intracellular calcium is reduced to inhibit Actin-myosin bonds, thus relaxing smooth muscles.

As a Beta 2-adrenergic owner, Salbutamol has an anti-allergy effect by acting on moisturizing to inhibit the release of intermediate chemicals that cause bronchospasm such as histamine, neutral white leukemia (NCF) and Prostaglandin D2.

Zensalbu Nebules 2.5 bronchodigade in both normal people and asthma patients or chronic obstructive pulmonary disease (COPD) after drinking. The drug also increases the clearance of mucus (proven in COPD patients and in normal people).

Beta-2-ADRENERGIC receptor stimulates the spreading effects: Increasing free fatty acids, insulin, lactate and sugar; Reducing the concentration of potassium in serum.

pharmacokinetics

salbutamol is eliminated mainly in feces. The majority of Salbutamol dose used in inhaled lines is excreted within 72 hours. Salbutamol is connected to plasma proteins to 10%.

After using the inhalation line, about 10 to 20% of the dose reaches lower gas paths. The rest is kept in aerosol equipment or deposited in the mouth of the pharynx, where the drug is swallowed. The deposits on the gas path are absorbed into the lung tissue and circulatory but not metabolized in the lungs.

By the cycle, Salbutamol is metabolized in the liver and is excreted mainly in urine in a constant form and phenolic sulphate form.

The swallowing part of the inhaled dose is absorbed from the gastrointestinal tract and is significantly transformed into Phenolic Sulphat. The whole drug is unchanged and the link is excreted mainly through the urine.

Need for oxygen breathing when there is a risk of oxygen deficiency due to ventilation.

Due to the many types of aerosol machine on the principle of continuous air flow, maybe the drug will be released into the surrounding environment. Therefore, it is advisable to use Zensalbu Nebules in a room with good ventilation, especially in the hospital when many patients use the aerospm at the same time.

Only use the drug when prescribed by a doctor.

Dosage

Adults and children: The appropriate starting dose of Salbutamol solution when solution is 2.5mg.

may increase the dose to 5mg. Can be used up to 4 times/day. When treating heavy gases in adults, the dose may be higher, up to 40mg/day, under the strict supervision of the doctor at the hospital.

Zensalbu Nebules's clinical effectiveness in children under 18 months of age is not clear. Should consider using oxygen supplement therapy because there may be a lack of transient oxygen oxygen.

If the previous effective dose was poorly responded for at least 3 hours, need a doctor immediately.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

In case of overdose of poisoning, depending on the severity of severity may manifest a number of symptoms such as uncomfortable, headache, dizziness, dizziness, nausea, restlessness, tremor of limb, fast heartbeat, arrhythmia, blood pressure change, convulsions, can lower potassium potassium.

Handling

Stop using salbutamol immediately. Treatment of symptoms. For beta blockers (for example, Metoprolol tartrat) if necessary and need to be in the risk of bronchospasm. The above treatment must be conducted in the hospital.

When using too high dose can cause adverse effects, so it should only increase the dose or increase the frequency of use when indicated by a doctor. In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose?

No data.

Warning and caution when taking drugs

in severe or unstable asthma patients, should not be treated or should not be treated mainly with bronchodilators.

Be cautious when used with patients with toxic armor.

There has been a report on acute angle glaucom in some patients in combination with ipratropium bromid.

Therefore, cautious when used with other anti -cholinergic drugs.

Do not leave the solution or the fog to fly into the eyes.

Beta-2-adrenergic agent treatment is mainly with injection and aerosol that is at risk of severe hypoassian potassium.

Particularly cautious in severe asthma patients because this side effect can increase when used with xanthin derivatives, diuretics and without oxygen. Need to monitor blood potassium in these cases.

Salbutamol can cause changes in metabolic recovery, such as increased blood sugar.

Patients with diabetes may not compensate for these changes in metabolism and have reported on acidosis. This effect may increase when used with corticosteroids. Precautions when taking high doses in patients who are treating acute asthma attacks, monitoring the increase in serum lactate concentration and metabolic acidosis.

Using drugs for pregnant and lactating women

pregnancy

Salbutamol has been shown to cause teratogenic rats when subcutaneous injection at a corresponding dose of 14 times the dosage in humans. There is no scale research in pregnant women. Do not use drugs in this object without knowing the relationship between salbutamol and deformities.

Breastfeeding period

Salbutamol is excreted a small amount of breast milk. The impact of the drug on breastfed babies is not known, so be careful when taking the drug in nursing women.

In cases where the physician needs to consider the benefits and the risk of being encountered.

affects the ability to drive and operate machinery

salbutamol can cause the most common effects, especially irritation, tremor or headache, dizziness. Therefore, it affects the ability to drive and operate machinery.

Drug interaction

Avoid use in combination with unsatisfactory beta owners such as propanolol, isoprenalin, dobutamin, because of the increased cardiovascular effects.

Not for patients being treated with imao (Monoamin oxydase inhibitors) or three -round antidepressants: the effect of salbutamol on the blood vessel system may be affected.

When indicating Salbutamol, it is necessary to reduce other beta stimulants if taking the drug for treatment.

Beta and Salbutamol receptor receptors inhibit each other's effects of loss of treatment and can make the disease worse.