Zibifer OPV oral solution to treat anemia, potential iron (30ml)

ATC code: B03AB05.

iron is found in all cells and has some important functions. Iron ions are components of some enzymes needed for energy metabolism (for example, cytochrom oxidase, xanthin oxidase, dehydrogenase success) and are also present in the necessary compounds for the transport and use of oxygen (for example, hemoglobin, myoglobin). Cytochrom is used as an electron transport agent in the cell. Hemoglobin is an oxygen from the lungs to tissues and myoglobin that facilitates the muscles using oxygen and reserves. Iron deficiency can affect important functions and lead to disease and death.

Use iron preparations to treat abnormalities in red blood cells due to iron deficiency. Iron stimulating erythrocytes as well as not cure hemoglobin disorders are not due to iron deficiency. Using iron preparations also reduces other iron deficiency manifestations such as tongue pain, difficulty swallowing, nail and skin disorder, cracking in the corner of the lip.

Dynamic pharmacokinetics

iron is absorbed mainly in the duodenum and the first segment. Iron absorption increases when the iron reserve in the body is low or the demand for iron increases. The iron passes through the gastrointestinal mucosa to the bloodstream and immediately attaches it to the transferin. Transferin transports iron to bone marrow and iron merged into hemoglobin. Iron released due to the destruction of hemoglobin is retained and reused by the body. Iron excreted mainly through cells: skin, gastrointestinal mucosa, nails and hair, only an amount of iron spots are eliminated through bile and sweat.

For iron deficiency treatment, anemia, treatment lasts about 1-2 months.

Preventive treatment

Pregnant women: 30 mg/day.

Babies are normal for normal months without breast milk or a part of breast milk: dose of 1 mg/kg/day starts from the birth and continues in the first year.

Lightweight or preterm birth: Starting 2 - 4 mg/kg/day starting at least 2 months, so starting from 1 month of age.

The maximum dose must not exceed 15 mg/day for young children, normal weight or light weight.

Children ≥ 10 years (puberty): Male: 2 mg/day; Female 5 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

How to handle: If taking more than 10 mg/kg of elemental iron has occurred within 4 hours, the stomach must immediately wash with vomiting, or better, gastric lavage through the catheter. If the patient has vomited many times, and especially blood vomiting, vomiting drugs are not used. Gastric lavage should be done with warm water or sodium bicarbonate solution 1 - 5%. The stomach is with DINATRI phosphate solution is also used. Deferoxamine is also used as an additional substance for the gastric solution to create complexes with the elemental iron in the intestinal tract.

In case of overdose, immediately contact the doctor or go to the nearest hospital.

What to do when you forget 1 dose? Do not double the dose to compensate for the forgotten dose.

Caution when using

large amounts of iron causes strong corrosion effects on the gastrointestinal mucosa.

Can temporarily stain the tooth enamel or toothpaste of the newborn.

Using iron preparations for a long time can cause hemosiderin infection, iron tissue diseases.

Too much iron is associated with increased sensitivity to infections.

This drug contains:

methyl paraben and propyl paraben, which can cause allergic reactions (can react late).

Sugar and sorbitol. Patients with rare genetic problems are fructose intolerance, glucose-galactose or sucrase-Isomaltase deficiency.

The effect of the drug on the ability to drive and operate machinery

has not recorded a adverse reaction report or no research on the effect of the drug on the ability to operate machinery, train driving, higher people working and other cases.

Use drugs for women during pregnancy and nursing mothers

Pregnant and lactating women: The drug is used for pregnant and lactating women.

Interactive drugs

Antacids reduces iron absorption. Should take iron as far as this medicine as possible.

Simultaneously using iron -containing oral preparations can hinder some quinolon anti -infections. Do not take iron -containing pills simultaneously with quinolon or within 2 hours after taking quinolon.

Oral iron -containing preparations inhibit the absorption of tetracyclin from the gastrointestinal tract and vice versa, resulting in a decrease in serum concentration of both antibiotics and iron. If taken simultaneously of the drugs is necessary, patients should take tetracyclin 3 hours after or 2 hours before taking iron -containing pills.

Response to the treatment of iron can be delayed in patients with chloramphenicol.

Oral iron -containing preparations reduce the effects of Cupruretic Penicilamin, probably due to its reduced absorption. Should take iron -containing medicine away from this drug (at least 2 hours).