Zyzocete thephaco medicine reduces symptoms of allergic rhinitis, urticaria (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cetirizin

Ingredient

Composition information	Content
Cetirizin	10mg

Uses

indications

Zyzocete medicine is indicated in the following cases:

Treatment of symptoms of allergic rhinitis long -term season. Histamine, receptor antagonist H1 - ATC code: R06A E07

Cetirizin has anti -allergic effect but does not cause drowsiness in pharmacological doses. Cetirizin has a selective antagonistic effect in H1 receptor, but almost no effect on other receptors, so there is almost no antagonistic effect acetylcholin and no serotonin antagonistic effect. Cetirizin inhibits the early stage of allergic reactions through histamine intermediaries and also reduces the relocation of inflammatory cells and reduces the release of intermediate substances in the late stage of allergic reactions.

Pharmacokinetics

absorption

The drug is absorbed quickly after drinking. The peak concentration in the blood is 0.3 micrograms/ml, achieved later (1.0 ± 0.5) hours. Oral bioavailability does not change when taking the drug with food. Cetirizin's absorption level is not reduced by food, but the absorption rate is reduced.

Distribution

Expression distribution volume is 0.5 l/kg. The associated ratio with plasma protein is 90 - 96%.

Metabolism

Cetirizin is not metabolized for the first time. About 2/3 of the dose is exported in the form of unchanged urine. Half life eliminates plasma for about 10 hours. Cetirizin has linear dynamics at the dose of 5-60 mg.

Elimination

The drug in breast milk but almost does not pass the blood -brain barrier. The clearance of the kidney is 30 ml/min and the sale time is approximately 9 hours.

Before taking Zyzocete thephaco medicine reduces symptoms of allergic rhinitis, urticaria (10 blisters x 10 tablets)

How to use

cetirizin is used orally, can be taken with or outside meals.

Dosage

Children from 6 to 12 years old: Take 5 mg x 2 times/day (1/2 tablets 2 times/day).

Adults and children over 12 years: Take 10 mg/day (1 tablet/day).

Elderly: Currently, there is no recommended data to reduce the dose in the elderly with normal kidney function.

Patients with impaired renal function, adjustable dose according to CLCR as:

Normal kidney function: ClCr> 80 ml/min: 10 mg x1 times/day

mild kidney failure: 50

Moderate kidney failure: 30 What to do when overdose? In children may be excited. When the overdose symptoms need to see a doctor for treatment. Need to stop taking the medicine and notify the doctor or pharmacist. In serious overdose, it is necessary to cause vomiting and gastric lavage along with supportive methods. Up to now, there is no specific antidote.

What to do when you forget 1 dose? Do not take double the dose to compensate for the forgotten dose.

Side Effects

When using Zyzocete, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Chicken sleep phenomenon, dizziness , headache , nausea.

Systemic: Fatigue

Digestive system: dry mouth , sore throat.

Uncommon, 1/1,000

Mental: agitation.

nervous: Perception. stomach - intestines: diarrhea .

Skin and subcutaneous tissue: itching, redness, rash.

Digestive system: Increasing salivation, anorexia or increased appetite.

Systemic: weakness, fatigue.

Rare, 1/10,000

The immune system: hypersensitivity.

Mental: aggression, confusion, depression , hallucinations, insomnia.

nerve: convulsions. heart: tachycardia.

Liver: Abnormal liver function (increased transaminase, alkaline phosphatase, γ-GT and bilirubin).

Skin and subcutaneous tissue: urticaria. Other: edema.

Very rare, ADR

Blood and lymphatic system: thrombocytopenia.

Immune system: Anaphylaxis.

Mental: Movement does not pay attention repeated many times.

eyes: blurred vision.

Skin and subcutaneous tissue: Vascular nervous edema.

Kidney and urinary: difficulty urinating, bedwetting.

No frequency:

Metabolism and nutrition: Increase appetite.

Mental: suicide thoughts.

nerve: Memory loss, memory impairment. eyes: dizziness.

Kidney and urinary: Urinary retention.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Zyzocete medicine is contraindicated in the following cases:

People with a history of allergies to cetirizin, with hydroxyzin.

Sensitive people with any ingredients of the drug.

Children under 6 years old.

Patients with severe renal failure with glomerular filtration less than 10ml/min.

Be cautious when using

need to adjust the dose in moderate or severe renal failure and people who are artificial kidneys.

Need to adjust the dose in people with liver failure in combination with kidney failure.

In some patients using Cetirizin have a chicken sleep, so be careful when driving, or operating the machine, because it is easy to cause danger. Avoid simultaneous use of cetirizin with alcohol and central neurological inhibitors, because of the effect of these drugs.

Caution for patients with epilepsy and patients at risk of convulsions.

Products contain lactose, so the patient does not tolerate galactose, lactase deficiency or malposion of glucose-galactose should not be used.

The ability to drive and operate machinery

Because the drug can cause sleep, dizziness, nausea, it is necessary to be careful to use the drug when driving and operating machinery.

Pregnancy

although Cetirizin does not cause teratogenicity in animals, there is no adequate studies on pregnant women, so should not be used during pregnancy.

breastfeeding period

cetirizin excreted in milk, so nursing mothers should not use.

Interactive drug

Avoid in combination with central neurological inhibitors such as sedation and alcohol.

Cetirizin rods decrease slightly when taken with 400 mg of theophylin.

Do not use slow -release tablets in combination with cetirizin hydrochloride and pseudoephedrin hydrochloride in patients who are taking or stopping imao.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Thanh Hoa Medical Materials Equipment Joint Stock Company is the name of Mono (formerly known as "Thanh Hoa Medical Materials and Repair Station" established in 1976), in 1986, it was renamed Thanh Hoa Medical Materials Equipment Company. Themco is one of the units operating in the field of manufacturing and trading medical and pharmaceutical equipment and pharmaceutical equipment in Vietnam. Themco has a team of masters, engineers, doctors, pharmacists, bachelors ... high professional qualifications, specialized training at home and abroad, promptly meeting the needs of the quality of customers inside and outside the province. The entire operation of Themco is strictly controlled by the quality management system according to ISO 9001: 2015 standards by the WQA organization of the UK of the UK to supervise, evaluate and grant certificates.

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