Phospholipid antibody syndrome

Phospholipid antibody syndrome's disease overview

Phospholipid syndrome (antiphospholipid syndrome) occurs when the immune system creates the wrong antibodies that make blood more blood coagulation. This can cause dangerous blood clots in the arteries or veins in the legs, kidneys, lungs and brain.

Pregnancy phospholipid resistance detected in pregnant women can lead to a continuous miscarriage. This is also one of the most common causes of stroke in young people. It is estimated that 1 person with a stroke before 40 years old may have APS.

Pathological phospholipid syndrome affects all age groups but the most common between the ages of 20 and 50. It is first diagnosed in people with lupus (lupus lupus. system erythema) but later it was discovered that APS could occur (this is called the main APS). Currently, there is no way to treat antiphospholipid syndrome that can only use drugs that can reduce risk. Blood coagulation

The consequences of antipholipid syndrome (APS) are blood clots (thrombosis) and pregnancy problems, especially recurrent miscarriage. This can happen at any time during pregnancy but the most common is from 3 to 6 months. APS can also cause other pregnancy problems, such as high blood pressure (pre -eclampsia), children and premature births. APS is currently recognized as one of the most important causes of recurrent miscarriage.

Other problems sometimes related to APS include:

Heart problems - The heart valves may thicken and do not work, or your arteries may be narrowed because their walls become thicker to angina.

Renal problems - APS can cause blood vessels, leading to high blood pressure.

Infertility - Testing for anti -Phospholipid antibodies (APL) is becoming a habit at infertility clinics.

Skin problems - Some people have a rash, often seen at the knees or arms and wrists, with a thread model (called Reto reticular).

Low platelet quantity - Some people with APS have very low platelets - usually no symptoms, although people with very low quantities can be easily bruised or bruising or Strange bleeding or too much.

Causes of Phospholipid antibody syndrome's disease

Antiphopholipid syndrome occurs when the immune system attacks the wrong body of your body that produces antibodies that cause blood to freeze. Antibodies often protect the body against invaders, such as viruses and bacteria.

Antiphopholipid syndrome can be caused by a hidden condition, such as autoimmune disorders

Some drugs.

Unknown cause

Symptoms of Phospholipid antibody syndrome's disease

Signs and symptoms of antiphopholipid syndrome may include:

Blood clots on the legs lead to pain, swelling and redness. These blood clots can move to the pulmonary obstruction.

Make miscarriage many times or stillbirth.

Other complications of pregnancy include dangerous high blood pressure (pre -eclampsia) and premature birth. stroke can occur in a young person with antiphospholipid syndrome but no risk factor is known for cardiovascular diseases.

Against the brain anemia (ray). Similar to stroke, rays usually only exist for a few minutes and does not cause permanent damage.

rash. Some developers develop rashes

Signs and less common symptoms include:

Mental symptoms: chronic headache, including migraine; Memory and convulsions are possible when a blood clot blocks blood flow to the parts of your brain.

cardiovascular disease: Antipholipid syndrome can damage the heart valve. bleeding: Some people have reduced blood cells needed for blood clotting. This can cause bleeding, especially from your nose and gums, bleeding under the skin

Depending on which agency is affected by blood clots and levels of blood flow obstruction to that agency, untreated antiphospholipid syndrome can lead to damage. The agency permanently or death. Complications include:

Renal failure: This can lead to reduced blood flow to your kidney.

Stroke leads to reduced blood flow to part of your brain that can cause a stroke, which can lead to permanent nerve damage, such as partial paralysis and partial paralysis. loss of speaking ability.

Cardiovascular problems: A blood clot on the leg can damage the valves in the vein, causing blood to flow to the heart. This can lead to chronic swelling and discoloration in the lower legs of. Another complication may be heart damage.

Lung problem: pulmonary obstruction.

Pregnancy complications. They may include miscarriage, fetus, premature birth, fetal retardation and dangerous high blood pressure during pregnancy (pre -eclampsia).

People at risk for Phospholipid antibody syndrome's disease

risk factors for antipholipid syndrome include:

Sex: This situation is much more common in women than men.

Immune system disorders. There is another autoimmune condition, such as lupus syndrome or sjogren, increasing the risk of antiphospholipid syndrome.

Infection: This condition is more common in people with certain infections, such as syphilis, HIV/AIDS, hepatitis C or Lyme disease.

Drugs: Some drugs have been associated with antiphospholipid syndrome. They include hydralazine for high blood pressure, rhythmic regulating drugs, phenytoin anti -epilepsy (dantin) and antibiotic amoxicillin.

Family history: In the family there are people with APS

There may be antibodies related to antiphospholipid syndrome without developing signs or symptoms. However, these antibodies increase the risk of blood clots, especially if:

Pregnancy

Immobile for a while, such as lying on a bed or sitting on a long flight

Surgery

Smoking

Oral contraceptives or estrogen therapy for menopause

with high cholesterol and neutral fat levels

Prevention of Phospholipid antibody syndrome's disease

Currently there is no measure to prevent phospholipid resistance syndrome

Diagnostic measures for Phospholipid antibody syndrome's disease

Antiphopipid syndrome (APS) can only be diagnosed if:

There are three main blood tests used to diagnose APS. That is:

Anticardipin test

Anti -coagulation test lupus

Anti-beta-2-Glycoprotein tests.

To confirm the diagnostic diagnosis of antiphopholipid syndrome, antibodies must appear in the blood at least twice, in tests that are conducted 12 weeks apart. >

There may be antibodies of phospholipids and never develop any signs or symptoms. The diagnosis of antipholipid syndrome is only performed when these antibodies cause health problems.

Phospholipid antibody syndrome's disease treatments

Antiphopipid syndrome (APS) cannot be cured but the effect can be controlled. Treatment with anticoagulants (blood thinning) can help prevent both blood clots and miscarriage. The commonly used drugs are aspirin, warfarin and heparin.

Select drugs depending on different cases:

Aspirin: Diagnosis of APS but without a history of blood clotting, the doctor may recommend low -dose Aspirin daily. This is not guaranteed to prevent blood clots, but it is known to make blood less sticky.

Warfarin: There are other factors that increase the risk of blood clots, or if you have typical APS symptoms such as migraine or living, you may recommend you use Warfarin instead of aspirin. Also use warfarin when there is a history of blood clotting. The most serious side effect of warfarin during treatment is bleeding. Need to be closely monitored, regular coagulation tests

Treatment pregnant women have antiphospholipid syndrome :

During pregnancy, conventional treatment is low -dose aspirin; However, usually, APS pregnant women are given heparin daily as well as aspirin, especially if the previous miscarriage occurs in the middle to the end of the pregnancy or if there are other pregnancy complications such as pre -eclampsia.

If you are using Warfarin and you are pregnant, you will probably be changed to heparin. This is because Warfarin is likely to harm the baby.

When you are taking blood thinning medicine, you will increase the risk of bleeding.

Other supportive treatments

Exercise: Exercise regularly will help stay healthy and keep your heart healthy.

Diet and nutrition: There is an opinion that increasing the amount of essential fatty acids in your diet, especially omega-3 fatty acids in Oil fish, which can help reduce the risk of coagulation. However, there is no clinical trial to support this idea. Also, fish oil contains a large amount of vitamin A that can be harmful during pregnancy, so we do not recommend this if you think about having children. Eat a balanced, healthy diet that is important for your general health and can help prevent you from developing blood clots.

Stop smoking: Smoking will increase the risk of blood clotting.

Do not drink too much alcohol.

Do not use birth control pills: contraceptive pills increase the risk of coagulation

If you want to use hormone replacement therapy after menopause, this can also increase the risk of blood clots so you should discuss with your doctor. >

Regular health check -ups, especially in objects such as diabetes, high blood pressure or high cholesterol.

If you are taking medicine like Warfarin, be careful to avoid accidents because bruises may be worse.

If you are pregnant, you need regular health checks and do necessary monitoring tests.

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