Platelet hemorrhage

Platelet hemorrhage's disease overview

thrombocytopenic hemorrhage (Thrombotic thrombocytopenic Purpura-TTP) is a rare disorder that leads to microchemical anemia and thrombocytopenia. In this disease, small blood clots form throughout the body of the patient but these small blood clots may be very serious.

Small blood clots can block blood vessels to organs in the body, leading to damage to the functions of important organs, such as heart, brain and kidney.

Small blood clots can also use too much of your blood platelets so the patient's blood may then be unable to form blood clots when needed injury, and lead to the consequence of impossible. Hemostasis.

Causes of Platelet hemorrhage's disease

Genetic thrombocytopenia due to genetics

  • There is a form of thrombocytopenia that is inherited through generations according to the recessive gene mechanism. Parents carry the disease gene but often have symptoms of the disease. This genetic form is the result of a mutation in the AdamTS13 gene. This gene plays a role in producing an enzyme that makes blood clotting normally, abnormal coagulation occurs when the enzyme is lost. The enzyme is special proteins that increase the rate of metabolic chemical reactions.

    • thrombocytopenic hemorrhage due to suffering

    In other cases, the body confuses to create proteins that interfere with enzyme function, this condition is called thrombocytopenic hemorrhage due to many different causes such as infected. For example, blood and marrow stem cell transplantation. In some cases, thrombocytopenic hemorrhage may develop during pregnancy or if pregnant women have cancer or infection.

    Some drugs can lead to the development of thrombocytopenia, including:

  • estrogen
  • Hormone therapy
  • Chemotherapy
  • cyclosporine a

    • Symptoms of Platelet hemorrhage's disease

    If thrombocytic hemorrhage (thrombotic thrombocytopenic purpura-TTP), patients may have these symptoms on the skin:

  • There are bruises that are not clear why bruised. This sign is called the bleeding. 
  • Small red or purple spots look like rash.

    • Skin can turn yellow, called jaundice.

    Skin may look pale.

  • Patients with fevers
    • tired
  • Confused

    • Weak

  • Headache

    • In very serious cases, stroke, severe organs or coma may occur.

    complications may include:

  • Renal failure

    • Low platelet quantity

  • Low amount of red blood cells (caused by early breakdown of red blood cells)
  • The problem of the nervous system
  • Serious bleeding
  • Stroke

    • Transmission route of Platelet hemorrhage's diseasePlatelet hemorrhage

    Blood thrombocytopenia is a genetic disease, so it is unable to spread from patients to healthy people.  

    People at risk for Platelet hemorrhage's disease

    Due to thrombocytopenic hemorrhage is a genetic disease, therefore, the high risk of people with family members has had this disease. 

    Prevention of Platelet hemorrhage's disease

    Because scientists still do not know exactly the exact cause of thrombocytopenic hemorrhage, also known as idiopathic platelet hemorrhage , therefore, therefore , there is no effective method of preventing this disease.

    For children's platelet hemorrhage and platelet hemorrhage in infants , parents should pay attention when children have symptoms Above, it is necessary to take the medical facility as soon as possible.

    Diagnostic measures for Platelet hemorrhage's disease

    Diagnosis of thrombocytopenia often requires multiple tests. The doctor may start by physical examination and ask about the current symptoms of the patient.

    The doctor will also check the red blood cells under the microscope will indicate whether they are damaged from thrombocytopenia. The doctor will also check the blood component to know the low platelet level because of the increase in blood clotting, causing increased platelet use demand. They will also check the high concentration of bilirubin, this is the derived substance due to the breakdown of red blood cells.

    Some blood tests that doctors can also specify such as:

  • Antibodies, are proteins that interfere with the enzyme Adamts13
  • Creatinine level
  • Lack of enzyme activity Adamts13, causing thrombocytopenic hemorrhage

    • lactate dehydrogenase, released from damaged tissue caused by blood clots caused by thrombocytopenic hemorrhage

    Platelet hemorrhage's disease treatments

    Doctors often treat platelet hemorrhage by trying to bring the patient's blood clotting ability again.

    plasma

    conventional treatments for thrombocytopenic hemorrhage due to genetics is plasma intravenous injection. Plasma is the liquid part of the blood containing the necessary coagulation factors. 

    An alternative treatment that is common for thrombocytopenic hemorrhage is plasma exchange. This means that the plasma of a healthy donor will replace the patient's plasma. In the laboratory, a technician will separate plasma from the patient's blood using a special machine called cell separator. They will replace your plasma with donated plasma. After that, the patient will pass intravenously. Plasma is donated with water, protein and necessary coagulation factors. 

    Regardless of whether or not genetic hemorrhage hemorrhage is given, patients may need treatment every day until your condition is improved.

    Drugs

    If the plasma treatment is unsuccessful, the doctor may start treating with drugs to prevent the patient's body from destroying the enzyme adamts13. surgery

    In other cases, the spleen of the patient may need surgery to remove.

    See also:

  • The function of platelets
  • Why when dengue, platelets decrease?
  • What is the dengue and how to eat it to get well?

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