Systemic response syndrome

Systemic response syndrome's disease overview

Systemic inflammatory response syndrome are clinical signs created by activating the entire body's immune system. In other words, it is a common inflammatory reaction.

Systematic inflammatory syndrome (Sirs) is sometimes confused with blood infections, but there is an important difference between these two types that is the presence of infection. Systemic response syndrome may occur after injury, inflammation, ischemia or infection, while bleeding only occurs in the presence of infection. Sirs does not always occur after body injuries, but it is often a potential complication. When the presence of infection, sirs can develop into a blood infection if not treated quickly and appropriately.

Causes of Systemic response syndrome's disease

Systemic response syndrome can be caused by infection. However, infection is not the only cause of these symptoms. Some of the most common causes of this syndrome are burns, trauma, cardiovascular disease, lung disease due to heart problems and body surgery response, especially in cardiovascular surgery. >

Potential causes of general inflammatory response syndrome:

Infections

  • pneumonia
  • Infection of wound infection
  • endocarditis

    • Cellitis

    Urinary tract infections

    Poisoning shock syndrome

    necrotic

    Meningitis cholecystitis (gallbladder infection)

    No infection

    Burns, autoimmune disorders, cirrhosis, dehydration, injuries caused by electrical, hemorrhage, myocardial infarction, surgery, infusion reaction.

    Symptoms of Systemic response syndrome's disease

    Systematic syndrome is defined when there are two or more criteria:

  • temperature> 38 ° C or <36 ° C.
  • Frequency heart> 90 times/minute (*).
  • Breathing frequency> 20 times/minute (*) or PacO2 <4.3 kpa.
    • white blood cells> 12 x 10^9/l or <4 x 10^9/l or> 10% young leukocyte (Band form).

    For Systemic response syndrome Children, heart frequency and breathing on + 2SD (standard deviation) compared to normal value by age.

  • Non -specific sirs and may be caused by anemia, inflammation, trauma, infection or a combination of many lesions.
    • infection is determined when microorganisms invade the body to create an inflammatory response or the penetration of those microorganisms into normal tissue is sterile.
  • bacteria (bacteria) is the presence of bacteria in the blood, but this condition does not always lead to sirs or systemic infections (sepsis).
  • Systemic infection (sepsis) when sirs and the cause is due to bacterial infection (suspected or confirmed). In Vietnam, Sepsis is synonymous with blood infections. Diagnosis of infections based on gram transplant or dyeing (blood, pus, urine or other body fluids) or clinically based on (spotting pus, pus, diarrhea, pus burns ...).
  • Severe SEPSIS infection (Severe Sepsis) in accordance with the standards mentioned above and in combination with organ dysfunction, poor perfusion (hypoperfusion), or lowering Blood pressure.

    • Infections leading to hypotension are defined when "systolic blood pressure <90 mm Hg or decreases over 40 mm Hg compared to the initial blood pressure of the patient without due to raw. Other causes of hypotension. ”

    Patients in accordance with the standards of bacterial shock if there is prolonged and abnormal osical osical abnormalities.

    Multi -organ failure syndrome (MODS) is a condition with physiological disorders, in which the organ function does not maintain the home stability. >

    People at risk for Systemic response syndrome's disease

    Inflammatory response syndrome occurs with all ages, from children to adults.

    Prevention of Systemic response syndrome's disease

    Regular prevention includes deep veins and gastrointestinal ulcer prevention. Prolonged antibiotics when clinical indicators, narrow spectrum antibiotics when possible to avoid superinfection (for example, fever, leukocytes, or poor clinical changes).

    Diagnostic measures for Systemic response syndrome's disease

    The diagnosis of the syndrome is based on the presence of the above symptoms and some types of body injuries. When the doctor suspects this syndrome, you will need to do different tests such as blood culture, lactic acid and adequate blood formula.

    Diagnostic tests suspected of the systemic inflammatory response syndrome are:

  • Blood formula

    • Blood culture

  • Urine culture
  • Monkey culture
  • Cultivation of epidemics in the wound (if there is a wound)

    • Liver function

    Heart enzymes

  • Lactic acid
  • Measuring blood gases
  • Cerebrospinal fluid analysis

    • Systemic response syndrome's disease treatments

    There is no selective medication for systemic inflammatory response syndrome. Treatment by specific diagnosis, with the previous disease is progressive, using complicated prevention drugs. There is no drug to change the condition of response to systemic inflammation. Broad -spectrum antibiotics, insulin (in patients with hyperglycemia) and should consider steroids in patients with suitable standards to respond to systemic inflammation.

  • Treat the cause of Sirs.
  • When feasible should be cultured before using antibiotics.
  • Antibiotics with experience not used for all patients with sirs. Antibiotic indications include: doubting the cause of infection. Hematology is not stable. Leukemia decreased (or other immunodeficiency). Spleen cut or equivalent cause (due to severe infection after spleen cut).
  • Because anti -drug bacteria increase, the beginning should use wide spectrum antibiotics when the cause of Sirs is infection but the diagnosis of infections is not specific.
  • Need to monitor hyperglycemia in patients taking painkillers.
  • Patients with hypotension should infusion, and if the blood pressure is still low after the fluid has been compensated, vasoconstrictor should be used. All patients must be compensated enough by intravenous and common line, using 2 intravenous lines or a central vein.
  • Hyperglycemia is common in sirs even in patients without diabetes, even in patients without diabetes.

    • See also:

  • What is blood? How much blood type?
  • Things to know about blood formula tests

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