Zollinger-Elison syndrome

Zollinger-Elison syndrome's disease overview

Zollinger Ellison syndrome is a term that refers to pathological condition when one or more gastrin tumors appear in the digestive system. More than 80% of the cases of gastrin comes from the pancreas and duodenum, and the other position may experience lymph nodes around the pancreas, lymphocytes in the intestine, liver, gallbladder, ... Ability to secrete more gastrin, hormones stimulate the stomach to increase gastric acid secretion, thereby causing peptic ulcer complications.

This is not a common pathological condition, but more than half of patients suffer from Zollinger Ellison syndrome with malignant Gastrin tumors, many cases have metastasized to the metastases to the. Other organs in the body. The disease is often seen in men, at any age but most common in the age of 20 to 50. Treatment of Zollinger Ellison syndrome needs a combination of tumor removal surgery and treatment of ulcerative complications thick duodenum.

Causes of Zollinger-Elison syndrome's disease

So far the specific cause of the formation of tumors in Zollinger Ellison syndrome has not been well understood. However, it has clearly defined the nature of the tumor and a series of events occurring in the pathogen mechanism. Gastrin tumors form inside the pancreas or duodenum secreted a large amount of gastrin. Typically, gastrin is a hormone secreted by pancreatic cells, taking on the task of controlling the production of stomach acid. Increasing the level of gastrin in the blood stimulates the glands of the stomach mucosa to produce more stomach acids than the necessary level. This excess acid is the cause of clinical manifestations and leads to complications of gastric and duodenal ulcer.

Some cases of Zollinger Ellison syndrome are associated with multiple endocrine gland disease type 1 (multiple endCrine neoplasia syndromes 1 - Men 1). This is a genetic syndrome on chromosomes that are usually inherited. Patients with enzyme syndrome 1 appear tumors in many endocrine glands such as pituitary glands, parathyroid glands, including pancreatic island with tumors.

Symptoms of Zollinger-Elison syndrome's disease

Peptic ulcer is the most common complication in Zollinger Ellison syndrome, so clinically the symptoms of peptic ulcer are also a common manifestation of the disease. People with Zollinger Ellison syndrome often face the following symptoms:

  • Abdominal pain, feeling burning, scratching up the upper area or the lower left side of the left flank.
  • Nausea, vomiting. In heavy situations, patients may vomit with bright red blood or bruising
  • Bearing, heartburn
  • Gastroesophageal reflux, esophagus
  • Poor eating, not delicious, prolonged can cause weight loss, body weakness.
  • Gastrointestinal disorders, fat diarrhea

    • The level of clinical manifestation varies depending on the patient with one or more ulcers and ulcers causing complications. The peptic ulceres in Zollinger Ellison syndrome may appear alone or concentrated in many clusters in the duodenum and stomach. Clinical manifestations are often recurrent and repeated if the patient is only treated with the regimen of regular stomach ulcers.

    Transmission route of Zollinger-Elison syndrome's diseaseZollinger-Elison syndrome

    Zollinger Ellison syndrome is a disease that has unknown disease. Some cases are recognized related to enzyme syndrome 1. This is a common genetic disease on chromosomes, so there is no infectiousness. People with Zollinger Ellison syndrome are caused by an enamel syndrome that does not spread to others when interacting with each other.

    People at risk for Zollinger-Elison syndrome's disease

    The objects that are considered to be at higher risk of Zollinger Ellison syndrome than usual are people with relatives in the family with Zollinger Ellison syndrome, especially the direct relatives like parents and English. siblings.

    Prevention of Zollinger-Elison syndrome's disease

    Because the cause of Zollinger Ellison syndrome has not been well understood, the Zollinger Ellison syndrome can currently be considered as an effective disease. When there is any abnormal signs in the digestive tract, patients need to visit at medical facilities with a specialized digestive major for diagnosis of early detection and distinguishing with similar causes. Other.

    Diagnostic measures for Zollinger-Elison syndrome's disease

    Diagnosis of Zollinger Ellison syndrome accurately and promptly play an important role in determining the effectiveness of treatment. The establishment of a diagnosis requires a coordination between clinical examination, personal and family history exploitation as well as appointing appropriate subclinical tests such as:

  • Quantitizing the blood concentration in the blood: The gastrin tumors in Zollinger Ellison syndrome produces a large amount of gastrin so the high level of gastrin is a sign that the patient is suffering from Zollinger Ellison syndrome. This test often requires patients to fast before, and do not use drugs such as H2 resistance and proton pump resistance.

    • Stomach pH measurement: performed in combination with gastrin quantitative tests in the blood, in order to determine the increase in gastric acid secretion. In patients with Zollinger Ellison syndrome, there is an increase in gastric acid secretion and high blood gastrin levels.

  • Gastrointestinal endoscopy: When clinically, there are symptoms of suggestive gastrointestinal ulcer, the doctor will indicate peptic endoscopy to determine the location, level Damage of ulcers. Peptic endomoscopy is also a means of hemostatic treatment in cases of acute ulcerative ulcers and recurrent gastrointestinal bleeding.

    • Endoscopic ultrasound: This is a subclinical medium made in combination with duodenal endoscopy that can help detect tumors in the head of the pancreatic and duodenum.

    Abdominal ultrasound: This is a cheap, non -invasive subclinical means and can be done many times but the ability to detect primary tumors is low, plays a role in work Distinguish diagnosis with other diseases.

  • CT scan or abdominal MRI: Detect the primary gastrin tumors of the disease at a low rate, but showed many advantages in the case of detection of metastases to up to Other organs in the body.

    • Histological tests: The tissue samples taken from ulcerative ulcer through duodenal endoscopy or tissue samples are taken directly from the primary tumor as a cytetric to help identify Histological nature of lesions, or in other words can know benign or malignant damage.

    Zollinger-Elison syndrome's disease treatments

    Treatment of Zollinger Ellison syndrome mainly includes surgery to remove the gastrin tumors from the digestive tract and treat peptic ulcer complications.

    Surgery to remove tumors can be considered a thorough treatment, helping to heal completely in nearly half of the patients. After the surgery, tumors should be conducted a biopsy to make anatomy to determine the nature of benign or malignant tumor. For malignant tumors, removal surgery should be conducted more widely, sometimes it is necessary to coordinate with chemotherapy and radiation.

    Treatment of peptic ulcer by medical methods (using drugs). Note: These groups of drugs have many side effects that are worth considering if abuse such as stomach acidosis, osteoporosis, increased risk of fractures in patients over 50 years old, helpless, reduced libido in men Gender, ... Therefore, the use of drugs must be done under the guidance and prescription of specialists. The patient is absolutely not allowed to use the drug or stop using the drug without the consent of the doctor.

    See also:

  • How to treat stomach ulcers effectively
  • Note to patients with peptic ulcer >
  • When do you need to perform stomach cancer screening?

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