Acalabrutinib vs. ibrutinib: How do they compare?
Acalabrutinib, a treatment for chronic lymphocytic leukemia (CLL), appears to have a lower risk of adverse events (such as atrial fibrillation) in comparison to ibrutinib. A 2021 phase III study in the Journal of Clinical Oncology found that while both medications have similar efficacy, acalabrutinib was better tolerated with fewer side effects. In clinical studies:
Researchers have found that acalabrutinib is a more selective Bruton’s tyrosine kinase (BTK) inhibitor. The way that both acalabrutinib and ibrutinib work is by irreversibly binding to and destroying the cancerous B lymphocytes. Acalabrutinib’s increased selectivity means that the risk of off-target cells, or noncancerous cells, is much lower than in ibrutinib, which thus results in a lower risk of adverse effects.
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