Can you crush Biktarvy tablets?

Official answer

by Drugs.com

Crushing Biktarvy tablets and adding it to a liquid like water, milk or juice has not been studied and is not recommended by the manufacturer. In addition, no data is available on splitting Biktarvy tablets in half, and this practice is not advised. There is no commercially available liquid formulations of Biktarvy in the U.S.

The prescribing information for Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide fumarate or BIC/FTC/TAF) does not contain information about crushing or splitting the tablet before administration.

No pharmacokinetic studies are available that have evaluated a crushed Biktary tablet in a liquid (eg, milk, water, juice) compared to a whole tablet, or a split vs. whole tablet. Pharmacokinetic studies would give information about how crushing or splitting the tablet would affect properties of the medicine such as absorption.

Studies evaluating the bioequivalence of solid, crushed and dissolved forms of Biktarvy are ongoing according to ClinicalTrials.gov.

Data on file from Gilead, the manufacturer of Biktarvy, states that tenofovir (TAF) and emtricitabine (FTC) are soluble in water, while bictegravir (BIC) is practically insoluble (solubility of 0.1 mg/mL in water at 20°C). TAF, when dissolved in water, has a bitter and burnt flavor.

Biktarvy tablets are film-coated, most likely to help mask the bitter flavor. In general, you should not crush film-coated tablets. The coating may be necessary to prevent rapid breakdown of the medicine or to hide the taste.

Biktarvy is a prescription medicine that is used without other HIV-1 medicines to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children who weigh at least 14 kg (3 lbs).

In October 2021 the FDA approved a new low-dose tablet form of Biktarvy (bictegravir 30 mg / emtricitabine 120 mg / tenofovir alafenamide 15 mg) for children weighing at least 14 kg to less than 25 kg who are virologically suppressed or new to antiretroviral therapy.

How should I take Biktarvy?

Take Biktarvy exactly as your doctor prescribes. Do not crush, split or dissolve Biktarvy tablets unless your doctor tells you to. Typically, Biktarvy tablets are taken by mouth (swallowed whole) once a day. You may take Biktarvy with or without food.

If you take a multivitamin or mineral supplement that contains iron or calcium, take it with food at the same time you take Biktarvy.

Follow your healthcare provider instructions about any limitations on food, beverages, or activity. Ask your healthcare provider or pharmacist about medicines that should not be taken with Biktarvy.

Case Reports

There are case reports in the literature that document the use of crushed Biktarvy, but it is important to know that these results cannot always be generalized. These data are observational and uncontrolled and may not be applicable to you. Talk to your doctor first before you split or crush a Biktarvy tablet.

The manufacturer of Biktarvy states that crushing and dissolving or splitting tablets is not recommended. Do not crush or split Biktarvy unless your doctor prescribes it this way.

A 64-year old male patient with HIV received crushed Biktarvy tablets due to difficulty swallowing due to esophageal cancer and trouble swallowing (dysphagia).

A 39-year woman diagnosed with HIV and toxoplasmosis received nasogastric (NG) feeds due to acute neurologic deterioration, right hemiparesis (difficulty with movement) and dysphagia (trouble swallowing).

This is not all the information you need to know about Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Biktarvy information here, and discuss this information and any questions you have with your doctor or other health care provider.