Can you take Verzenio after Ibrance fails?
Both Verzenio and Ibrance are CDK 4/6 inhibitors, a type of targeted treatment that helps to reduce the growth and spread of cancer cells in the body. The active ingredient in Verzenio is abemaciclib and in Ibrance it is palbociclib.
Because Verzenio and Ibrance are similar treatments and have not been compared in head-to-head trials, the benefits of switching to Verzenio after Ibrance has failed is unknown.
However, research has shown that breast cancer cells can acquire resistance to CDK 4/6 inhibitors by producing higher amounts of CDK6. This will be shown by tumor growth in imaging studies.
What is the difference between Verzenio and Ibrance?
There may also be some advantages for Verzenio over Ibrance.
There may be some disadvantages too. Verzenio is more likely than Ibrance to cause diarrhea; however, most patients can manage this side effect with the anti-diarrhea medication loperamide.
How do Verzenio and Ibrance work?
Verzenio and Ibrance belong to the class of medicines known as CDK4/6 inhibitors.
CDK4/6 inhibitors target particular enzymes, called CDK4 and CDK6. CDK stands for cyclin-dependent kinase, and it is an enzyme that is important for cell division. CDK4/6 inhibitors interrupt signals that stimulate the growth of cancerous cells.
Certain cancers, for example, hormone-receptor-positive breast cancer, are more likely to have disturbances in CDK4/6, and CDK 4/6 inhibitors may form part of the treatment protocol.
Most often, CDK4/6 inhibitors are given at the same time as hormonal therapy (such as an aromatase inhibitor or fulvestrant), although Verzenio may be used alone to treat hormone receptor-positive, HER2-negative metastatic breast cancer in pre-treated patients.
Research suggests CDK4/6 inhibitors may increase the time people have before cancer spreads. More evidence is needed to determine their impact on overall survival.
Common side effects include fatigue and gastrointestinal disturbances, such as nausea, severe diarrhea, and vomiting. Bone marrow suppression resulting in neutropenia and leukopenia may also occur, although anemia and thrombocytopenia are less common. In general, the side effects associated with CDK4/6 inhibitor therapy are less severe than those experienced with chemotherapy.
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