Can you take Xeljanz with antibiotics and antifungals?
Xeljanz (tofacitinib citrate) can interact with other medications, including certain antibiotics and antifungal medications. In some cases the interaction means that it is not recommended to take Xeljanz and the other drug at the same time, while in other cases it simply means that the dose of Xeljanz you take will need to be reduced.
Xeljanz is primarily metabolized - processed by the body - by CYP3A4, an enzyme in the liver. Taking Xeljanz with other drugs that inhibit or induce CYP3A4 is likely to affect the way your body breaks down Xeljanz, meaning that you could get too much or too little of the drug. Xeljanz is also metabolized to a lesser extent by another enzyme called CYP2C19.
Taking Xeljanz and strong inducers of CYP3A4 is not recommended
Rifampin (Rifadin, Rimactane) is an antibiotic used to treat and prevent tuberculosis (TB). It is also a strong inducer of CYP3A4. It is not recommended to take Xeljanz and rifampin together because rifampin may reduce how well Xeljanz works as it decreases your exposure to the drug.
Adjusting your dose of Xeljanz is recommended when taking it with moderate or strong CYP3A4 inhibitors
The antifungal drugs itraconazole (Sporanox, Tolsura) and ketoconazole (Nizoral) are strong inhibitors of CYP3A4. Fluconazole is a moderate inhibitor of CYP3A4, but also a strong inhibitor of CYP2C19. The antibiotics clarithromycin (Biaxin XL) and erythromycin (E.E.S, Eryc, Erythrocin, Eryped) are also examples of strong inhibitors of CYP3A4.
Taking these drugs at the same time as Xeljanz can increase your exposure to the drug, meaning that the amount of Xeljanz you receive is increased, along with your risk of side effects.
It is recommended that you reduce your dose of Xeljanz while taking moderate or strong inhibitors of CYP3A4. Check with your doctor about what dose of Xeljanz you should take.
Xeljanz’s prescribing information recommends the following dosage adjustments (see table below) for patients taking strong CYP3A4 inhibitors, such as ketoconazole, or moderate CYP3A4 inhibitors that are also strong inhibitors of CYP2C19, such as fluconazole.
Condition that Xeljanz is being used to treat | Recommended Xeljanz dosage adjustment |
Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis | |
Ulcerative colitis | |
Polyarticular course juvenile idiopathic arthritis | |
Related medical questions
- What happens when you stop taking Xeljanz?
- How long does it take to work?
- Can I drink alcohol while taking Xeljanz?
- What is it used for and is it a biologic?
- Does it cause hair loss?
- Can you take Xeljanz with antibiotics and antifungals?
- Does it cause weight gain?
- Does it cause high blood pressure?
- Is Xeljanz approved for ankylosing spondylitis?
- What are JAK inhibitors and how do they work?
- What happens when you stop taking Xeljanz?
- Which JAK inhibitors are approved in the U.S?
- How long does it take to work?
- Can I drink alcohol while taking Xeljanz?
- What is it used for and is it a biologic?
- Does it cause hair loss?
- Can you take Xeljanz with antibiotics and antifungals?
- Does it cause weight gain?
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions