Do I need any blood tests while taking Xalkori?
Yes, you will need blood tests while you take Xalkori to help monitor your liver and kidney function, red and white blood cell counts, and in some cases, your electrolytes or blood sugar levels. These tests are done to help follow your response to treatment, look for possible side effects, and adjust your drug dose, if needed.
Your doctor may also order a blood test to determine if you are pregnant. Xalkori can cause harm to an unborn baby.
Two of the most common types of blood tests ordered in patients being treated for cancer are:
Why do I need blood tests for Xalkori treatment?
Based on your blood test results, your doctor may need to reduce your Xalkori (crizotinib) dose, or temporarily or permanently stop treatment. This will help to minimize any dangerous side effects. Do not change the dose or stop treatment unless your healthcare provider tells you to.
Here are some of the tests your doctor may order:
Complete Blood Count (CBC)
Red blood cells, white blood cells, platelets
Your doctor may order a blood test known as a complete blood count (CBC) with a differential. This test looks at the number and types of blood cells. You may require this blood test weekly, monthly or more often, especially if you develop a fever or infection.
Blood Chemistry Panel (metabolic profile)
Liver
In some people, Xalkori can cause liver toxicity that can be very severe or deadly. Your doctor will order tests to monitor your liver function every 2 weeks during the first 2 months of treatment, then once a month, or more, as needed. Tell your doctor before you start treatment if you have any liver problems.
These liver function tests look at liver enzymes known as ALT (alanine transaminase) and AST (aspartate aminotransferase), total bilirubin and alkaline phosphatase levels.
Tell your doctor if you have any type of liver problems before you start treatment. If you have moderate or severe liver disease, your doctor may decide to lower your dose of Xalkori. Your doctor may look at your aspartate aminotransferase (AST) and total bilirubin levels to decide if a dose adjustment is needed.
Tell your healthcare provider right away if you get any of the following new or worsening symptoms, which may indicate liver toxicity:
Kidney
Tell your doctor before treatment if you have any type of kidney problems. If you have severe kidney disease you might need to take a lower dose of Xalkori.
Your doctor may order these blood tests to assess your kidney function.
Your doctor will use a calculated number called the creatinine clearance (CrCl) to determine if you need dose adjustments of Xalkori for kidney disease. CrCl is calculated using inputs such as your age, weight, height, sex and serum creatinine level.
Electrolytes
Your doctor may order blood chemistry tests that measure the electrolytes in your body like sodium, potassium, chloride, magnesium, as well as bicarbonate. These substances help to keep your body’s fluid levels normal and help the function of your organs such as your heart, muscles, and other organs. Your doctor may also check your glucose (blood sugar) levels.
Tell your doctor right away if you have trouble with swallowing, vomiting, or diarrhea during treatment with Xalkori. Severe nausea, vomiting and diarrhea can occur with Xalkori and may lead to dehydration. Dehydration can lower your levels of electrolytes and can be dangerous. Your doctor will give you medicine to help lower nausea and vomiting when you start Xalkori treatment.
If you have significant vomiting or diarrhea, your doctor may order oral or intravenous rehydration solutions to help replace your fluids and electrolytes.
Tell your healthcare provider right away if you feel dizzy or faint or have abnormal heartbeats or if you take any heart or blood pressure medicines. Also let them know if you have heart problems, including a condition called long QT syndrome.
Pregnancy Test
If needed, your doctor will determine if you are pregnant before starting treatment with Xalkori. They can determine your pregnancy status by ordering a blood test or a urine test. Xalkori can cause harm to an unborn baby when given to a pregnant woman.
Talk to your doctor about effective contraception (birth control) for both you and your partner during treatment.
How long until I get my lab tests with Xalkori?
Unclear or delayed test results can cause worry for anyone. You should be able to see your lab test results online from the lab as soon as they are available. This usually does not take longer than one week, but can vary. Ask your doctor how long until your lab tests are back.
This is not all the information you need to know about Xalkori (crizotinib) for safe and effective use and does not take the place of your doctor’s directions. You may need different tests than the ones listed here. Review the full Xalkori information and discuss this information and any questions you have with your doctor or other health care provider.
Related medical questions
- How effective is Xalkori?
- Will I need to use Xalkori long term?
- Is Xalkori the same as Opdivo or Keytruda?
- Do I need any blood tests while taking Xalkori?
- How long does it take for Xalkori to work?
- How to pronounce Xalkori?
- What cancers are treated with Xalkori?
- How effective is Xalkori?
- Will I need to use Xalkori long term?
- Is Xalkori the same as Opdivo or Keytruda?
- Do I need any blood tests while taking Xalkori?
- How long does it take for Xalkori to work?
- How to pronounce Xalkori?
- What cancers are treated with Xalkori?
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