Does it cause weight gain?
Ajovy (fremanezumab-vfrm) is a monoclonal antibody in the class of medicines known as calcitonin gene-related peptide (CGRP) inhibitors. It helps to prevent migraine headaches by binding to the CGRP ligand to prevent receptor binding.
Ajovy, from Teva Pharmaceuticals, is used to help prevent migraine headache attacks in adults 18 years of age and older. It is not used to treat an acute migraine headache.
Which migraine drugs cause weight gain?
In clinical studies submitted to the FDA for approval of CGRP inhibitors, weight gain was not listed as a possible side effect and does not appear in product labels. Some anecdotal reports and surveys have suggested patients may see weight gain with CGRPs, especially Emgality (galcanezumab), but this may be due to other factors.
Other FDA-approved CGRP inhibitors for migraine prevention include:
Emgality is also approved to treat cluster headache episodes in adults.
Older medications used for migraine prevention (but originally were approved for other uses like high blood pressure, depression or seizures) are well-known to be linked with weight gain.
Life-style modification can help to improve your headache status, and may include a plan of weight loss and increased activity. Work with your doctor to adjust your diet and lifestyle to encourage weight loss and greater activity, if needed. Always contact your healthcare provider for any side effects that concern you.
Bottom Line
Weight gain has not been reported in clinical studies as a side effect with the migraine prevention medicine Ajovy. Some anecdotal reports do suggest CGRP inhibitors may cause weight gain.
Other factors related to migraine, such as lack of activity due to chronic headache pain or altered eating habits may play a role in weight gain.
Older medicines from different classes, such as amitriptyline, verapamil or valproate, can be linked with weight gain. Talk to your doctor about weight gain with migraine medicines if this is a concern for you.
This is not all the information you need to know about Ajovy for safe and effective use. Review the full product information here, and discuss this information with your doctor or other health care provider.
Related medical questions
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- Does it cause weight gain?
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