How are Inlyta and Keytruda used in kidney cancer?
Inlyta and Keytruda were approved by the FDA in April 2019 as a combination therapy for first-line treatment of kidney cancer (advanced renal cell carcinoma or RCC) in adults. Advanced kidney cancer means the cancer has spread or cannot be removed by surgery.
Inlyta and Keytruda are given until the kidney cancer has progressed, there are unacceptable side effects, or for Keytruda, up to a period of 24 months. Your doctor will decide how many treatments you need.
Inlyta is also approved:
What is advanced renal cell carcinoma?
You have two kidneys, which are bean-shaped organs located on either side of the backbone in the mid-back area. Kidney cancer starts when normal cells in the kidney change into abnormal cells. These abnormal cells then grow out of control and may spread.
The kidneys have several important functions:
There are several types of kidney cancer, but renal cell carcinoma (RCC) is the most common type. About 90% of kidney cancers (90 of every 100) are RCC.
People can live a normal, healthy life with only one kidney.
Why are Inlyta and Keytruda combined?
Keytruda is a type of immunotherapy drug called an Immune Checkpoint Inhibitor. It binds to the PD-1 receptor on the T-cell to help block cancer cells from linking to and inactivating the cancer-fighting T-cells (an anti-PD-1 therapy)
Inlyta is considered a targeted treatment, not an immunotherapy drug. It is a tyrosine kinase inhibitor and vascular endothelial growth factor receptor inhibitor (VEGF/VEGFR inhibitor). It blocks cell proteins and signals directed at blood vessels to help slow down the growth of new blood vessels that fuel the spread of cancer growth.
Renal cell carcinoma is a type of kidney cancer where programmed death ligand-1 (PD-L1) expression may contribute to cancer growth and vascular endothelial growth factor (VEGF) plays a key role in growth of blood vessels that supply the tumor.
How well does Inlyta and Keytruda work in kidney cancer?
In a clinical trial with 861 patients with advanced renal cell carcinoma, the combination of Keytruda and Inlyta was compared with sunitinib (Sutent) given alone, another tyrosine kinase inhibitor. Statistically significant results were shown in favor of Keytruda and Inlyta for several clinical outcomes.
What kind of side effects are common with Inlyta and Keytruda?
Common side effects of Inlyta when given with Keytruda include:
These are not all the side effects that may occur with these treatments. More serious side effects, such as infusion reactions and autoimmune reactions can occur. Review the side effects in more detail and talk to your doctor about what you can expect with this treatment.
Bottom Line
This is not all the information you need to know about Inlyta or Keytruda for safe and effective use and does not replace your doctor's instructions. Review the full product information, and discuss this information with your doctor or other health care provider.
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- How are Inlyta and Keytruda used in kidney cancer?
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- What is the difference between Opdivo and Keytruda?
- Can you take prednisone with Keytruda?
- Is it covered by Medicare / Medicaid?
- Is Xalkori the same as Opdivo or Keytruda?
- Pembrolizumab vs. nivolumab: how do they compare?
- How are Inlyta and Keytruda used in kidney cancer?
Disclaimer
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