How does Nexavar work? Is it a chemo drug?
Nexavar is an oral cancer drug that is thought to work by blocking certain proteins inside and on the surface of the cancer cell. It also helps to prevent the growth of new blood vessels that help to “feed” the tumor’s growth. This may help kill the cancer cell and keep it from growing and spreading.
Nexavar (sorafenib) is used in adults to treat:
It is classified as a vascular endothelial growth factor (VEGF) inhibitor and tyrosine kinase inhibitor (multikinase inhibitor).
Nexavar was first approved by the FDA in 2005 and is manufactured by Bayer Healthcare. A generic product for Nexavar is now available, which may make this medicine more affordable.
Is Nexavar a chemotherapy drug?
Nexavar (sorafenib) is not a traditional chemotherapy drug but it is used to treat cancer. It is considered a targeted drug therapy and is given by mouth as an oral tablet.
Nexavar is classified as a tyrosine kinase inhibitor (TKI) and VEGF inhibitor (angiogenesis inhibitor). It is approved by the FDA to treat liver cancer, thyroid cancer and kidney cancer.
Does Nexavar cause hair loss?
Like many drugs used to treat cancer, Nexavar has been reported to cause patchy hair loss (alopecia) or hair thinning in 14% to 67% of patients. Hair loss or hair thinning is one of the more common side effects with Nexavar. The highest rates of alopecia have occurred in thyroid cancer studies.
Alopecia, or hair thinning or loss, is a side effect that can occur with many different cancer treatments but is usually reversible when treatment stops. Some people may not have significant hair loss, while for others it may be more noticeable. Sometimes hair may grow back a different texture (more curly) or slightly changed color.
Hair loss can be a distressing side effect for many patients, but there are ways to minimize this.
Related: Common Side Effects and Warnings with Nexavar (in more detail)
Always consult with your doctor and cancer-care team about any medication side effects during your cancer treatment.
This is not all the information you need to know about Nexavar (sorafenib) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
Related medical questions
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