How does semaglutide work for weight loss?
You will lose weight with semaglutide because you will eat less, and feel fuller when you do eat. Semaglutide does this by by targeting an area in the brain (called GLP-1 receptors) that help to regulate your appetite and how much you eat. It closely mimics a natural hormone in the body called incretin, which is made primarily in our digestive tract.
Semaglutide is used as a long-term weight loss treatment in addition to a healthy diet and exercise to help promote weight loss.
What is the mechanism of action of semaglutide?
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist and occupies the GLP-1 receptor in the brain that regulates appetite.
It should not be used with other semaglutide-containing products (such as Ozempic, Rybelsus) or other GLP-1 receptor agonist medicines.
GLP-1 works by helps people to lose weight in 3 ways:
Who can use semaglutide for weight loss?
Semaglutide for weight loss is approved to be used in adults and children 12 years of age and older based on their body mass index (BMI) and the presence of certain health conditions.
Semaglutide (Wegovy) is used in addition to diet and exercise for long-term weight management in:
You can learn how to calculate an adult BMI here. Have your child's pediatrician determine their BMI percentile based on the current charts.
Other prescription drugs that also contain semaglutide are Ozempic (injection) or Rybelsus (oral tablets). These brands are only approved to treat type 2 diabetes, together with diet and exercise, and are not specifically approved for weight loss, but can lead to weight loss.
How long does semaglutide take to work?
You may see some weight loss in the 4 weeks of semaglutide treatment, but the full effect can take several months. After 68 weeks, adults lost about 35 lbs (15.9 kg) in studies, on average.
Your doctor will slowly increase your dose when you start treatment to help lessen stomach side effects like nausea and diarrhea. It typically takes about 17 weeks to reach your final maintenance dose of semaglutide.
This is not all the information you need to know about semaglutide (Wegovy) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
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