How does Taltz compare to Cosentyx for psoriatic arthritis?
Taltz and Cosentyx are similar in the way they work, their side effects, and their potential for interactions, but Taltz does appear to provide patients with psoriatic arthritis (PA) with more quality-adjusted life-years (QALYs) compared with Cosentyx at a marginally lower cost. Cosentyx may have a quicker onset of effect.
Both Taltz and Cosentyx may be used to treat adults with psoriatic arthritis but Cosentyx is also approved for children with psoriatic arthritis over the age of 6. They both belong to the same class of medicines called interleukin inhibitors and work in the same way, that is to selectively bind to interleukin 17A (IL-17A) to reduce inflammation. Interleukin inhibitors are considered a breakthrough in psoriasis and psoriatic arthritis treatment because research has discovered that immune cell TH17 was a major cause of psoriasis and that interleukin-17A was the most abundant cytokine produced by TH17 cells.
Differences in effectiveness
Very few studies have directly compared Cosentyx with Taltz with regards to psoriatic arthritis. Taltz provided more quality-adjusted life-years (QALYs) compared with Cosentyx to patients with psoriatic arthritis (PsA) and concomitant moderate to severe plaque psoriasis at a marginally lower cost in one study published in PharmacoEconomics.
Another study that investigated patients with psoriasis reported that Cosentyx and Taltz were both highly effective in the short- and long-term treatment of psoriasis but that Cosentyx had a more rapid onset and Taltz longer effectiveness.
Other differences
Other differences between Cosentyx and Taltz include:
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