How effective is Lenvima?
Lenvima, a cancer medicine taken by mouth, has been shown in studies to extend progression-free survival (PFS) in kidney, liver, thyroid and endometrial cancer. In these various types of cancer, PFS has ranged from a median of 7.3 months to 23.9 months, depending upon use.
PFS is the length of time during and after cancer treatment that a patient lives with the disease but it does not get worse.
Lenvima may also be given in addition to other treatments such as everolimus (Afinitor) or pembrolizumab (Keytruda).
View study results with Lenvima here.
What does Lenvima treat?
Lenvima (lenvatinib) is an oral prescription medicine approved by the FDA for the treatment of:
Lenvima is a kinase inhibitor that blocks certain endothelial growth factor (VEGF) receptors. It works by blocking the signals directed at blood vessels to help slow down the growth and spread of certain types of cancer.
How will I take Lenvima?
Lenvima is taken as a an oral capsule once a day, with or without food, at the same time each day. Take it exactly as prescribed by your healthcare provider.
How effective is Lenvima for cancer in studies?
Thyroid cancer: Lenvima vs. placebo
In Feb. 2015, the FDA approved Lenvima to treat thyroid cancer. Lenvima was studied in 392 patients for the treatment of differentiated thyroid cancer (DTC), a type of thyroid cancer that can no longer be treated with radioactive iodine and is progressing. Patients received either Lenvima or a placebo (inactive) treatment during the study.
Progression-free survival (PFS) is the length of time during and after the treatment of the cancer that a patient lives with the disease but it does not get worse.
Advanced renal (kidney) cell cancer: Lenvima + Keytruda vs. sunitinib
Lenvima is used in combination with Keytruda (pembrolizumab) to treat adults with advanced renal cell carcinoma (a type of kidney cancer) as an initial (first-line) treatment. The use was approved by the FDA in August 2021.
In the Phase 3 CLEAR/KEYNOTE-581 trial, when Lenvima was given with Keytruda in patients with advanced renal cell cancer, this study showed a significant improvement when compared to Sutent (sunitinib) on progression-free survival (PFS), overall survival (OS) and confirmed objective response rate (ORR).
Advanced renal (kidney) cell cancer: Lenvima + everolimus vs. everolimus
Lenvima is also used in combination with everolimus to treat adults with advanced renal cell carcinoma following one prior treatment called antiangiogenic therapy, another type of cancer-fighting medicine. This indication was cleared by the FDA in May 2016.
In studies, when Lenvima plus Afinitor (everolimus) were given together in patients with renal cell cancer, the results showed a median progression-free survival (PFS) of nearly 3 times that of everolimus when given alone.
Hepatocellular (liver) cancer: Lenvima vs. sorafeni
In August 2018, the FDA cleared Lenvima for the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC), a type of liver cancer that cannot be fully removed with surgery.
Approval was based on a Phase 3 study against an active comparator (sorafenib, brand name: Nexavar) in unresectable hepatocellular carcinoma.
Endometrial cancer: Lenvima plus Keytruda (pembrolizumab) vs. chemotherapy
In July 2021, the FDA approved Lenvima plus Keytruda (pembrolizumab) for the treatment of patients with advanced endometrial carcinoma (EC) that IS mismatch repair proficient (pMMR), as determined by an FDA-approved test, or NOT microsatellite instability-high (MSI-H), who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation.
In this study, medication included:
The approval was based on the Phase 3 KEYNOTE-775/Study 309 study.
This is not all the information you need to know about Lenvima (lenvatinib) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
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