How effective is Verzenio?
Verzenio (abemaciclib) is a targeted treatment that helps to reduce the growth and spread of cancer cells in the body. It may be used to treat men or women with hormone receptor-positive, HER2-negative (HR+ HER2-), node-positive, early breast cancer at high risk of recurrence. It is also approved for HR+ HER2- advanced or metastatic breast cancer in men or women. Verzenio may be given when cancer has progressed or spread to other parts of the body after treatments such as anti-estrogens or chemotherapy have already been given.
Verzenio belongs to the class of medicines known as CDK 4/6 inhibitors which help to reduce the growth and spread of cancer cells in the body.
Clinical trials have shown favorable results for men or women with early breast cancer and high-risk clinical and pathological factors taking Verzenio plus tamoxifen or ET.
For women taking Verzenio plus anastrozole or letrozole:
For women taking Verzenio in combination with fulvestrant:
For women taking Verzenio as monotherapy:
Verzenio is usually taken twice daily. When taken regularly, consistent blood levels are achieved within five days. Gastrointestinal side effects, such as diarrhea, typically occur in the first month of treatment and can affect up to 81% of patients. The average time to onset of diarrhea was 6 to 8 days. Diarrhea can be severe and requires monitoring and proper management.
Who can use Verzenio?
Verzenio is indicated for the treatment of HR+ HER2- early breast cancer at high risk of recurrence in combination with endocrine treatment (tamoxifen or an aromatase inhibitor). It may also be used to treat HR+ HER2- advanced or metastatic breast cancer:
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