How effective is Xalkori?
Key Points
What kind of drug is Xalkori?
Xalkori (generic name: crizotinib) is a targeted drug therapy known as a tyrosine kinase inhibitor (TKI). It kills cancer cells by targeting a specific area with gene changes that leads to the cancer. Your doctor can test you for these gene changes, which are also called biomarkers.
Xalkori is given as an oral capsule or as oral pellets taken by mouth. It is used to treat ALK-positive (ALK+) or ROS1-positive (ROS1+) non-small cell lung cancer (NSCLC) that has spread to other parts of the body. This type of NSCLC is caused by defects in one of two genes: either the ALK (anaplastic lymphoma kinase) gene (ALK+), or the more rare ROS1 gene (ROS1+).
Xalkori is also approved to treat ALK+ Anaplastic Large Cell Lymphoma (ALCL), a rare form of non-Hodgkin lymphoma (NHL). ALCL makes up about 30% of cases of NHL in young people. About 90% of ALCL cases in young people are ALK-positive. Lymphoma is a cancer of the lymph system which is part of our immune system. NHL involves abnormal growth of white blood cells.
In July 2022, Xalkori was approved to treat anaplastic lymphoma kinase (ALK)-positive inflammatory myofibroblastic tumors (ALK+ IMT) in adults and children one year of age and older whose tumor cannot be removed by surgery, has returned, or failed previous treatment. ALK+ IMT involved solid, soft tissue turmors that often grow in the lungs, pelvis region or abdomen.
Studies of Xalkori for ALK+ NSCLC
Researchers looked at Xalkori treatment in a study with 343 patients with ALK+ NSCLC that had spread to other parts of the body (metastatic). Xalkori treatment was given to 172 patients and chemotherapy was given to 171 patients. The outcomes of the groups were compared. No one had received previous treatment for metastatic NSCLC.
Researchers also looked at the Objective Response Rate (ORR) of the ALK+ tumor, which measures tumor shrinkage. They found that 74% of patients responded to Xalkori treatment compared to 45% of patients taking chemotherapy. The tumor responses lasted a median time period of 11.3 months in people in the Xalkori group compared to 5.3 months in those who received chemotherapy infusions.
Studies of Xalkori for ROS1+ NSCLC
In a smaller study with 50 patients, investigators looked at how effective Xalkori was in patients with ROS1+ non-small cell lung cancer (NSCLC). ROS1+ NSCLC is more rare than the ALK+, occurring in only 1% of patients with NSCLC. Xalkori was not compared to chemotherapy treatment.
Studies of Xalkori for ALK+ ACLC
Xalkori was studied in 26 patients with ALK-Positive Anaplastic Large Cell Lymphoma (ALCL) that had come back after previous treatment or did not respond. Patient ranged in age from 3 to 20 years, with 11 years being the most common age.
Studies of Xalkori for ALK-positive Inflammatory Myofibroblastic Tumors (IMT)
Xalkori is approved to treat ALK-positive (ALK+) inflammatory myofibroblastic tumors (IMT) in adults and pediatric patients 1 year of age and older, that cannot be surgically removed, have returned, or when a previous treatment has failed. ALK+ IMTs, which are soft-tissue solid growths, commonly occur in the lungs, stomach area, or pelvis.
This is not all the information you need to know about Xalkori (crizotinib) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Xalkori information and discuss this information and any questions you have with your doctor or other health care provider.
Related medical questions
- How effective is Xalkori?
- Will I need to use Xalkori long term?
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- Do I need any blood tests while taking Xalkori?
- How long does it take for Xalkori to work?
- How to pronounce Xalkori?
- What cancers are treated with Xalkori?
- How effective is Xalkori?
- Will I need to use Xalkori long term?
- Is Xalkori the same as Opdivo or Keytruda?
- Do I need any blood tests while taking Xalkori?
- How long does it take for Xalkori to work?
- How to pronounce Xalkori?
- What cancers are treated with Xalkori?
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