How fast and effective is Nurtec ODT for migraines?
Nurtec ODT is a migraine medication that is used in adults:
Nurtec ODT (rimegepant) works by blocking the calcitonin gene-related peptide (CGRP) receptor.
How fast does Nurtec work?
Nurtec is an orally disintegrating tablet (ODT) that dissolves in the mouth without the need to take it with a glass of water. Because it dissolves in the mouth it is absorbed into the bloodstream quickly and can start working within an hour, with some people being able to get back to their normal activities after this time. It takes 1.5 hours for Nurtec to reach the maximum concentration in the body.
How effective is Nurtec for treating an acute migraine?
In the clinical study (Trial 1/NCT03461757) using Nurtec 75mg ODT or placebo pill they looked at the percentage of patients who were free from pain or free from their most bothersome migraine symptom after two hours.
Percentage of patients pain free after 2 hours
When looking at the percentage of patients from the treatment group, including all age groups, races, men and women, who were pain free after 2 hours:
Table of Percentage of patients pain free after 2 hours
Placebo | Nurtec ODT 75mg | Difference | |
Treatment group | 10.9% | 21.2% | 10.30% |
Age < 40 | 11.5% | 21.1% | 9.60% |
Age > 40 | 10.2% | 21.4% | 11.20% |
Women | 10.7% | 22.6% | 11.90% |
Men | 11.7% | 13.9% | 2.20% |
Percentage of Patients with Absence of their Most Bothersome Migraine Symptom
The study also looked at the absence in the most bothersome symptom (MBS) after 2 hours after dosing. MBS included photophobia, phonophobia, or nausea.
Table of Percentage of Patients with Absence of their Most Bothersome Migraine Symptom
Placebo | Nurtec ODT 75mg | Difference | |
Treatment group | 26.8% | 35.1% | 8.30% |
Age < 40 | 28.0% | 34.6% | 6.60% |
Age > 40 | 25.5% | 35.7% | 10.20% |
Women | 27.8% | 36.3% | 8.50% |
Men | 21.6% | 28.8% | 7.20% |
How effective is Nurtec ODT at preventing Migraines?
The clinical trial (Study 2; NCT03732638) looked at how effective Nurtec ODT was in preventing migraines. The study was a placebo controlled study with one group having Nurtec ODT and the other group receiving placebo, over a 3 month period. The number of migraines was measured for 4 weeks before patients started the trial and then compared the number of migraines in the last 4 weeks (week 9-12) of the trial.
Bottom line:
Related medical questions
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