How fast does Paxlovid work?

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Official answer

by Drugs.com

Key Points

  • Paxlovid, an oral antiviral medication, will start to work against COVID as soon as you take it, but you may not start to feel better right away.
  • It is important you start treatment as soon as possible, within 5 days of symptom onset and testing positive for COVID. Contact your doctor or pharmacist to determine if you are eligible for treatment, even if your symptoms are mild right now.
  • If you do not feel better or if you feel worse after 5 days, be sure to call your healthcare provider for further advice.

    • Most people who take one 5-day course of Paxlovid (nirmatrelvir and ritonavir) recover from COVID, although there is a possibility of COVID rebound. Currently there are no reports of severe outcomes related to COVID rebound.

    Paxlovid continues to be recommended for early-stage treatment (within 5 days of symptoms onset) of mild to moderate COVID-19 in people at high risk for severe disease. It can lessen symptoms and prevent hospitalization and death. Paxlovid reduces the risk of being hospitalized by 88% when taken within 5 days of symptom onset.

    Do I have to isolate myself after I finish Paxlovid?

    Whether you have taken Paxlovid or not, you can end home isolation after a full 5 days if:

  • your fever has resolved for 24 hours (without the use of fever-reducing medication
  • AND your symptoms are improving (eg, cough, shortness of breath).
  • You should continue to wear a well-fitting mask indoors (if around others) and in public for a full 10 days.

    • If you test positive again after just finishing Paxlovid you should restart the 5-day isolation period and contact your healthcare provider for further instructions.

  • You can end your COVID rebound isolation period after 5 full days if your fever has resolved for 24 hours (without the use of fever-reducing medication) and your symptoms are improving (eg, cough, shortness of breath).
  • However, you should continue to wear a well-fitting mask for another 10 days if rebound symptoms start.
  • Some people may continue to test positive even 10 days after COVID rebound begins, but are much less likely to be contagious by this time.

    • Most doctors do not prescribe a second round of Paxlovid for rebound. It is indicated only for a 5 day treatment in product labeling. Case reports suggest that people who develop COVID rebound after completing Paxlovid have either no symptoms or mild illness. Currently there have been no reports of severe outcomes related to COVID rebound.

    This is not all the information you need to know about Paxlovid (nirmatrelvir and ritonavir) for safe and effective use and does not take the place of your doctor’s directions. Review the full Paxlovid product information and discuss this information and any questions you have with your doctor or other health care provider.

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