How is Arzerra administered and how long to work?

Drugs.com

Official answer

by Drugs.com

Arzerra (ofatumumab) is administered by an intravenous infusion. It is diluted into a sterile bag of 1000mL sodium chloride for intravenous infusion which is then hung up and the infusion administered into one of your veins via an intravenous line. How long the infusion takes depends on your stage of Chronic Lymphocytic Leukemia (CLL) and if you have had treatment before, but initially Arzerra is usually administered over about 6 hours. The time of the infusion may be shortened, depending on how well you tolerate Arzerra.

How long does it take Arzerra to work?

Arzerra starts working right away but it may take several months before a difference is noted in the progression of your cancer. Trials investigating Arzerra for CLL looked at progression free survival and reported:

  • For patients assigned Arzerra with chlorambucil their previously untreated CLL did not worsen for a median of 22 months, compared to 13 months to those assigned chlorambucil alone
  • 82% of patients had a response including 12% whose cancer went away
  • The responses lasted for an average of 22 months.

    • In those people whose CLL had relapsed:

  • The disease did not get worse for an average of 29 months in those assigned Arzerra plus fludarabine plus cyclophosphamide, compared to 19 months to those assigned just fludarabine and cyclophosphamide
  • 84% of patients had a response including 29% whose cancer went away
  • Patients lived for an average of 56 months.

    • Related medical questions

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    Popular Keywords