How long does Suboxone stay in your system?

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Official answer

by Drugs.com
  • The effects of Suboxone last for 24 hours
  • After one dose of Suboxone, no trace of the drug would be expected to be found after 5 to 8 days in healthy people, or 7 to 14 days in those with severe liver disease.

    • Suboxone contains buprenorphine and naloxone and it may be used to treat opioid addiction.

    After the initial treatment period, Suboxone is usually given just once a day, and it’s effects will last at least 24 hours.

    When calculating how long Suboxone lasts in the body, you need to consider the elimination half-life of both drugs. This is the time it takes for half of the drug to be metabolized and eliminated in the body.

  • The elimination half-life of buprenorphine is 24 to 42 hours
  • The elimination half-life of naloxone is 2 to 12 hours.

    • Generally, it takes four to five half-lives for a drug to be totally eliminated from the body.

  • In most healthy people, no trace of Suboxone would be found after 120 to 210 hours (5 to 8 days).

    • Buprenorphine is metabolized and eliminated in the urine and feces. Naloxone is metabolized by the liver and excreted in the urine.

    In people with moderate-to-severe liver disease, the half-life of both buprenorphine and naloxone are significantly prolonged, naloxone more so than buprenorphine.

  • In moderate liver impairment, the half-life of buprenorphine is increased by 35% and naloxone is increased by 165%
  • In severe liver impairment, the half-life of buprenorphine is increased by 57% and naloxone is increased by 122%.

    • Based on a calculation of 5 half-lives for the drug to be totally removed:

  • For people with moderate liver disease, no trace of Suboxone would be expected to be found after approximately 160 to 284 hours (6 to 12 days)
  • For people with severe liver disease, no trace of Suboxone would be expected to be found after approximately 188 to 330 hours (7 to 14 days).

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