How to avoid yeast infections on Jardiance?

Official answer

by Drugs.com

Key Points

What is Jardiance used for?

Jardiance (empagliflozin) is a prescription drug used to help control glucose (blood sugar) in adults and children 10 years of age and older with type 2 diabetes. Jardiance is also approved by the FDA to lower the risk of:

Jardiance is given as an oral tablet once daily and is used in addition to diet and exercise. In adults, it can be added to other medicines for type 2 diabetes such as metformin, sulfonylureas, pioglitazone, and insulin.

Only the 10 mg dose of Jardiance is approved to lower the risk of further worsening of kidney disease, end-stage kidney disease (ESKD), death due to cardiovascular disease, and hospitalization in adults with chronic kidney disease (CKD).

In children, the only other oral medicine approved for type 2 diabetes is metformin. The safety of Jardiance was similar in children when compared to adults, with the exception of an increased risk of hypoglycemia (low blood sugar) whether or not children also used insulin.

Your doctor may occasionally change your dose. Be sure to tell your doctor if you take other diabetes medicines.

What drug class is Jardiance?

Jardiance, classified as an SGLT-2 inhibitor, is made by Boehringer Ingelheim Pharmaceuticals and Eli Lilly.

SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure in type 2 diabetes. They typically carry a low risk of hypoglycemia (low blood sugar levels) when used alone (used as monotherapy).

SGLT-2 inhibitors come as single-ingredient products or combined with other diabetes medicines. Other single-ingredient FDA approved medications in the SGLT-2 inhibitor class include:

Why do yeast infections occur with Jardiance?

The mechanism of how SGLT-2 inhibitors work in type 2 diabetes may be responsible for how the yeast infection occurs.

Does Jardiance cause yeast infections in both women and men?

Yes, genital mycotic (yeast) infections have been reported by the manufacturer in both men and women; however, they occur more frequently in women.

Patients with a history of recurrent or chronic yeast infections may be at greater risk, too.

What do studies say about genital yeast infections with Jardiance?

The manufacturer assessed five placebo-controlled clinical trials as a whole (pooled analysis) to look at the incidence of genital yeast infections with Jardiance.

Overall, the incidence of genital mycotic infections (also referred to as vaginal mycotic infection, vaginal infection, genital infection fungal, vulvovaginal candidiasis, and vulvitis in study analysis) was increased in patients treated with Jardiance compared to taking a placebo.

Table 1. Incidence of Genital Yeast (Mycotic) Infections with Jardiance

Most patients do not need to stop treatment due to the occurrence of a genital yeast infection. In patients treated with Jardiance 10 mg or 25 mg, only 0.2% of patients (2 out of 1,000) discontinued therapy. No patients stopped treatment in the placebo group.

Incidence in women

In pooled Phase 3 studies of over 1,300 women, yeast infections of the vagina (vulvovaginitis) occurred in 5.4% (5.4 out of 100) of patients taking 10 mg daily of Jardiance, 6.4% of women taking the 25 mg strength, and in 1.5% of women using an inactive placebo.

Incidence in men

In men, yeast infection of penis (e.g., balanitis or balanoposthitis) may occur, especially in uncircumcised males and patients with chronic and recurrent infections.

In pooled Phase 3 data of over 1,600 men, yeast infections of the penis occurred in 3.1% (3.1 out of 100) of patients taking 10 mg daily dose of Jardiance, 1.6% of men taking the 25 mg strength, and in 0.4% of men using an inactive placebo.

Symptoms of Genital Yeast Infections

Genital yeast infections are one of the most common side effects linked with the use of Jardiance, even though the incidence is low. Diabetes itself may also increase the risk of having a yeast infection.

Recognizing when a yeast infection is occurring is important for early treatment and successful therapy. When you are prescribed Jardiance, be sure to talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis.

Your doctor may prescribe prescription medications or suggest you use an over-the-counter (OTC) antifungal medicine. Be sure to contact your doctor right away if your symptoms do not improve with treatment.

Symptoms of a vaginal yeast infection in women (vulvovaginitis, candidiasis):

Symptom of a yeast infection of the penis in men (balanitis or balanoposthitis):

Some men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of the penis. Balanitis is most likely to occur in men who have a tight foreskin that is difficult to pull back, or who have poor hygiene. An allergy to condoms or spermicides may also worsen balanitis caused by yeast.

How can I prevent or treat yeast infections with Jardiance?

When yeast infections occur, they usually respond well to treatment. Up to 90% of vaginal yeast infections are cured within 2 weeks or less, often within a few days. Most cases of balanitis respond to treatment within three to five days. Conventional oral prescription or even over-the-counter topical antifungal treatment are usually effective.

The yeast, Candida albicans, is the most common cause of vaginal candidiasis.

Common treatments include:

Longer treatment regimens may be needed if your symptoms are severe or you have frequent or chronic yeast infections. Your doctor might also choose to switch you to a different class of diabetes medication, if required, but this is usually not necessary.

Sexual contact can pass an infection back and forth between partners. If this occurs, you and your partner will need treatment at the same time to prevent further infections.

Lifestyle changes to help avoid a yeast infection

Lifestyle changes may not prevent yeast infections with Jardiance, but they can help to make life more comfortable and hasten your improvement.

Bottom Line

Maintaining control of your blood sugar levels can help you to avoid worsening yeast infections in type 2 diabetes. Genital yeast infections are not common, but can occur with use of Jardiance. Most infections are mild, easily treatable, and improve within a few days after medication is started.

Consider wearing loose-fitting, breathable cotton clothes and change out of wet or moist clothes as quickly as possible.

Speak with your doctor about the side effect of genital yeast infections before you start taking Jardiance. Learn to recognize the symptoms of a yeast infection and have an action plan in place with your doctor.

This is not all the information you need to know about Jardiance for safe and effective use. Review the full Jardiance information here, and speak to your health care provider if you have questions or concerns.