Lenvatinib vs sorafenib: for first line treatment in HCC?
Lenvatinib is approved to be used alone as the first treatment for a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed by surgery. “First-line treatments”, such as surgery, radiation or drug treatments, are options that might be tried as your first therapy for cancer.
Based on the National Comprehensive Cancer Network (NCCN) 2020 patient guidelines for liver cancer treatment, the preferred first-line drug therapy options for liver cancer include:
Study: Lenvatinib vs sorafenib in inoperable liver cancer
The REFLECT study, conducted by the manufacturer of lenvatinib, compared it to sorafenib treatment, another first-line drug therapy, in 954 patients with previously untreated and inoperable hepatocellular carcinoma (HCC).
Study results showed that lenvatinib was found to be no worse than (non-inferior to) treatment with sorafenib (another first-line drug used for liver cancer that can’t be removed with surgery). In other words, lenvatinib did not show an improvement in survival (how long patients lived) when statistically compared to sorafenib.
In addition, the time that patients lived without their disease getting worse (median progression-free survival or PFS) was doubled with lenvatinib (7.3 months) compared to sorafenib (3.6 months). This equates to a 36% reduction in risk of disease progression or death.
Lenvatinib also showed nearly 3.5 times the overall response rate (ORR) of sorafenib: 41% (range or CI: 36% to 45%) for lenvatinib vs. 12% (range or CI: 10% to 16%) for sorafenib. ORR is the percent of patients whose tumor is destroyed or reduced in size by a drug. The ORR is composed of the complete response (CR) and the partial response (PR) rates. Improvement in numbers shows that the drug is working.
What kind of side effects occurred with lenvatinib and sorafenib?
Side effects of drug treatment are important to consider when looking at treatment options for cancer treatment
Side effects led to a dose reduction or interruption in treatment in 62% of patients receiving lenvatinib, and led to lenvatinib treatment discontinuation in 20% of patients.
More serious side effects (grade 3-4) in patients being treated for HCC in either treatment arm:
Common side effects (at least 20%) with lenvatinib in patients being treated for liver cancer overall:
Bottom Line
This is not all the information you need to know about lenvatinib and sorafenib for safe and effective use. Review the full drug product information at the above links and discuss this information, and any questions you have, with your doctor or other health care provider.
Related medical questions
- How long do you take Lenvima?
- How effective is Lenvima?
- How long does it take for Lenvima to work?
- What type of drug is Lenvima? Is it a chemo drug?
- Is this an immunotherapy or chemotherapy drug?
- How long does it take to work?
- Lenvatinib vs sorafenib: for first line treatment in HCC?
- Is this used for endometrial cancer?
- How does it work?
- How long do you take Lenvima?
- How effective is Lenvima?
- How long does it take for Lenvima to work?
- Is this an immunotherapy or chemotherapy drug?
- How long does it take to work?
- What type of drug is Lenvima? Is it a chemo drug?
- Lenvatinib vs sorafenib: for first line treatment in HCC?
- Is this used for endometrial cancer?
- How does it work?
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions