Mounjaro vs Ozempic: How do they compare?
Overview
Both Mounjaro and Ozempic are prescription medicines, used alongside diet and exercise, to help control blood sugar (glucose) levels in adults with type 2 diabetes. Ozempic is also approved to lower the risk of a major cardiovascular event (like a heart attack or stroke) in patients with type 2 diabetes. Mounjaro has not yet received this indication, although studies are ongoing.
Mounjaro and Ozempic may also lead to significant weight loss, but are not yet specifically approved by the FDA for this use. However, if weight loss is your only goal, the brand of semaglutide known as Wegovy is approved for weight loss (but not blood sugar control in type 2 diabetes).
Gastrointestinal side effects, like nausea and diarrhea, are the most common side effects seen with these drugs. Slowly increasing the dose, as directed by your healthcare provider, may help you more effectively manage the stomach side effects.
Both Mounjaro and Ozempic are given as a weekly subcutaneous injection in the abdomen, thigh, or upper arm. You, or a caregiver, can learn to give these injections at home. The Rybelsus brand of semaglutide is also available as an oral tablet for type 2 diabetes.
These medicines are expensive if you are fully paying out-of-pocket as no generic option is available on the U.S. market. Insurance, discount coupons, copay cards, and manufacturers financial assistance may help lower your out-of-pocket costs, if you qualify. Visit here for more information.
Do Mounjaro and Ozempic both lower A1C?
Yes, both drugs can also help you reach your A1C goal, which can prevent diabetes complications like heart and blood vessel disease, nerve damage, kidney failure and vision loss.
A1C is a laboratory test that shows the average amount of sugar (glucose) in your blood over the past 2 to 3 months. This can help you and your doctor gauge your long-term control of your diabetes.
Your blood sugar levels may start to decline right away, but it can take 2 to 3 months to reach your target A1C goal. A1C is a simple blood test that shows the average amount of sugar (glucose) in your blood over the past 2 to 3 months, giving you an idea of longer-term control of your diabetes.
People with type 2 diabetes usually have an A1C blood test twice per year. For most, but not all people, the goal is less than 7%. Your healthcare provider can inform you of your specific A1C goal.
Are Mounjaro and Ozempic in the same drug class?
Mounjaro and Ozempic are both in the class of drugs known as incretin mimetics but have some differences. Mounjaro acts on both GIP and GLP-1 receptors, while Ozempic acts only on GLP-1 receptors; however, both drugs are effective treatments for type 2 diabetes.
These medicines should not be used together or with other GLP-1 or GIP receptor agonists.
How are they given?
Both Mounjaro and Ozempic are given as weekly injections under the skin (subcutaneously) in the stomach area (abdomen), thigh or upper arm. You, or a caregiver, can learn to give these injections at home using an injector pen.
Which is more effective - Mounjaro or Ozempic?
Mounjaro was compared to semaglutide (Ozempic) in the 40-week, Phase 3 SURPASS-2 study with over 1,870 participants. Researchers sought to see how these drugs affected A1C reduction. A key secondary endpoint was the amount of weight lost. Neither Mounjaro or Ozempic are approved for weight loss at this time, but in patients with type 2 diabetes, they may lead to some weight reduction.
Mounjaro 5 mg, 10 mg, and 15 mg injections were compared to semaglutide (Ozempic) 1 mg injections in adults with type 2 diabetes whose blood sugars were not controlled with 1,500 mg/day of metformin alone. Patients in the study had an A1C of 8.3% and a weight of 94.1 kg (207 lb) at the beginning of the study.
How do side effects compare between Mounjaro and Ozempic?
Gastrointestinal (digestive tract) side effects are the most common side effects for both Mounjaro and Ozempic, and incretin mimetics in general. Stomach side effects are most frequent when doses are first initiated. Slowly increasing the dose, as recommended by your healthcare provider, may help to reduce stomach side effects.
Rates of side effects cannot be compared outside of direct comparative clinical studies as patient populations, doses and study designs may differ.
Side Effects: Mounjaro
In Mounjaro studies, the most commonly reported side effects, compared to a placebo (an inactive agent) are:
Overall, stomach side effects occurred in 37% to 44% of Mounjaro-treated patients (compared to 20% of patients on a placebo). In addition, 3% to 6.6% of patients receiving Mounjaro stopped treatment due to gastrointestinal side effects (like nausea, vomiting, and/or diarrhea) compared to placebo (0.4%). Most reports of nausea, vomiting, and/or diarrhea occurred during dose escalation at the start of treatment and decreased over time.
Other reported side effects for Mounjaro included: hypoglycemia (low blood sugar), increased heart rate, allergic reactions, injection site reactions, acute gallbladder disease, and increases in amylase and lipase (pancreas enzymes).
Side Effects: Ozempic
The most common side effects with Ozempic are:
Overall, stomach side effects occurred in 33% to 36% of Ozempic-treated patients (compared to 15% of patients on a placebo). In addition, 3.1% to 3.8% of patients receiving Ozempic stopped treatment due to gastrointestinal side effects compared to 0.4% of the placebo group.
Other reported side effects for Ozempic included: hypoglycemia (low blood sugar), injection site reactions, elevated amylase and lipase (pancreas enzymes), cholelithiasis (gallstones), increases in heart rate, and fatigue, dysgeusia (altered taste), allergic reactions and dizziness.
The labeling for both Mounjaro and Ozempic carry Boxed Warnings for possible thyroid tumors, including cancer, which has been seen in animal studies. Do not use these products if:
In Sept. 2023, the FDA updated the side effects for Ozempic (semaglutide) to emphasize that an ileus, an intestinal blockage, has been reported as a possible side effect. In addition to Ozempic, this warning also exist for Mounjaro (tirzepatide) and other semaglutide products Wegovy and Rybelsus.
An ileus is an intestinal blockage that results in the failure of the intestinal contents to pass through the gut, but it doesn't involve a physical blockage. In paralytic ileus problems with the muscle or nerves found in the intestine interfere with normal muscle contractions.
Because these side effects were voluntarily reported, the FDA cannot reliably determine how often this side effect occurs or if the drug actually caused the ileus. Speak to your doctor about your risk for this side effect.
Symptoms of an ileus can include:
These are not all of the side effects or warnings for these drugs. For more information, see:
Comparing Mounjaro vs. Ozempic Prices
Mounjaro cost
The dose for one Mounjaro (tirzepatide) weekly injection ranges between 5 mg and 15 mg. The typical maintenance dose for Mounjaro is 5 mg per week injected subcutaneously (under the skin). Mounjaro single-dose pens are available in 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 and 15 mg doses. The maximum dosage is 15 mg subcutaneously once weekly.
Ozempic cost
The dose for one Ozempic (semaglutide) weekly injection ranges between 0.5 mg and 2 mg. The typical maintenance dose for Ozempic is 0.5 to 1 mg injected subcutaneously (under the skin) once a week. Ozempic injection pens are available in 2 mg, 4 mg and 8 mg per pen (multi-use, single patient pen). The maximum recommended dose of Ozempic is 2 mg weekly.
*Prices are estimates and are subject to change. Cost can vary for these medicines depending upon your pharmacy and location, your insurance and copays, deductibles, patient financial assistance or any discount coupons you may have.
Using an online coupon may help lower your costs if you are paying cash out-of-pocket for your medicine. Manufacturers may also be able to offer Savings Cards if you qualify. For more information and coupons, visit:
This is not all the information you need to know about Mounjaro or Ozempic for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.
Related medical questions
- Mounjaro vs Ozempic: How do they compare?
- Ozempic vs Wegovy: What's the difference between them?
- What happens when you stop taking Ozempic?
- How does Ozempic (semaglutide) help with weight loss?
- Will my insurance cover Ozempic?
- How does semaglutide work for weight loss?
- What is Ozempic face and how to avoid it?
- What is the difference between Soliqua and Xultophy?
- How does Ozempic affect blood pressure?
- What's the easiest way to open a Rybelsus bottle?
- How does semaglutide work for weight loss?
- What is the difference between Soliqua and Xultophy?
- Why am I not losing weight on Ozempic?
- How does Ozempic affect blood pressure?
- What is Ozempic face and how to avoid it?
- What foods should I eat or avoid when taking Rybelsus?
- Why does Ozempic cause a dry mouth or taste changes?
- Does Wegovy make you pee a lot or urine smell?
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