Sotyktu vs Otezla: How do they compare?
Sotyktu and Otezla are both oral prescription medicines used to treat moderate-to-severe plaque psoriasis, but they work in different ways. Sotyktu blocks a protein called TYK2 (tyrosine kinase 2) to help lower inflammation and improve the severity and number of psoriasis lesions. Otezla works by blocking the phosphodiesterase type 4 (PDE4) enzyme to lower inflammation.
What are they approved for?
In September 2022, the FDA approved Bristol Myers Squibb’s Sotyktu (deucravacitinib) for adults to treat:
Otezla (apremilast), made by Amgen, was first approved in March 2014 and is used to treat adults with:
How are Sotyktu and Otezla taken?
Both drugs are taken orally as a tablet. Sotyktu is taken once per day and Otezla is twice per day.
Sotyktu is given as 6 mg orally once daily.
Otezla is given as 30 mg twice daily after a titration of slowly raising your dose over a period of 6 days.
Which is more effective - Sotyktu or Otezla?
The effectiveness of Sotyktu was compared to Otezla in the head-to-head study called POETYK PSO.
In the pivotal, head-to-head, phase 3 POETYK PSO clinical trials with 1,684 adult patients, Sotyktu, given at a dose of 6 mg orally once daily was more effective in improving skin clearance when compared to an inactive placebo pill and to oral Otezla (apremilast), given at a dose of 30 mg orally twice daily.
The superior effectiveness of Sotyktu compared to placebo and Otezla was seen at both 16 and 24 weeks, and responses from Sotyktu lasted throughout one year (52 weeks).
In addition, the POETYK PSO long-term extension (LTE) trial showed that effectiveness lasted throughout two years (112 weeks) of treatment in adult patients with moderate to severe plaque psoriasis.
Sotyktu has also led to greater clearing of scalp psoriasis in 16 weeks when compared to a placebo or Otezla.
How do common side effects compare between Sotyktu and Otezla?
It’s important to remember rates of side effects cannot be compared outside of direct comparative clinical studies as patient populations, doses and study designs may differ.
A side effect that has been commonly reported with both Sotyktu and Otezla includes upper respiratory tract infections.
Common side effects with Sotyktu are:
Common side effects with Otezla include:
Which is more expensive - Sotyktu or Otezla?
At this time, Sotyktu is more expensvie than Otezla, but both are costly medicines used to treat plaque psoriasis. Your insurance may pay for either product, but you may have to pay a deductible, copay, or co-insurance.
There are no generic alternatives for either product at this time, which could help you save money. The lower-cost generic option for Otezla called apremilast was approved by the FDA in February 2021, but it is not yet on the U.S. market, possibly due to patent protection challenges.
Your cost can vary based on your pharmacy and location, any coupons or discounts you may have, or if you have insurance or a patient assistance program through the manufacturer.
Check with your insurance company. If you are not able to afford the medicine, call the manufacturer who may be able to offer a copay card or other financial assistance.
What is the price for Sotyktu?
The dose for Sotyktu is 6 mg orally once daily. The cash price for a 30-day supply of Sotyktu 6 mg is around $6,501 (30 tablets), but most people do not pay this price.
Bristol-Myers Squibb, the manufacturer of Sotyktu, offers the Sotyktu 360 Support Copay Assistance Program. If you qualify and have commercial based insurance (not Medicare or Medicaid), you may be eligible to get Sotyktu for $0 per month. For additional information contact the Copay Assistance Program at 888-768-9588 (1-888-SOTYKTU).
To learn more about payment options, visit the Sotyktu Pricing Guide
What is the price for Otezla?
The maintenance dose for Otezla for psoriasis is 30 mg twice a day. The cost of brand name Otezla if you are paying cash is around $4854 for a month’s supply of medication (60 tablets); however, most people do not pay this price.
Amgen, the manufacturer of Otezla, offers a $0 co-pay program for eligible patients. If you use Medicare or Medicaid, or are paying cash, you are not eligible for the Otezla co-pay program, but may be eligible through the Patient Assistance Program (PAP) if you cannot afford your medication.
Call Amgen’s SupportPlus at 1-844-4OTEZLA (1-844-468-3952), 8 AM to 8 PM Monday through Friday for more information about coverage for Otezla.
To learn more about payment options, visit the Otezla Pricing Guide.
Note: The above price guides are based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
This is not all the information you need to know about these medicines for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.
Related medical questions
- Sotyktu vs Otezla: How do they compare?
- How is Sotyktu given / administered?
- How long can I take Sotyktu for?
- Sotyktu vs Otezla: How do they compare?
- How is Sotyktu given / administered?
- How long can I take Sotyktu for?
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