Trelegy vs. Breo: How do they compare?
Trelegy Ellipta is an orally inhaled medicine approved by the FDA as a maintenance treatment for asthma and chronic obstructive pulmonary disease (COPD) in adults. Trelegy Ellipta is inhaled once per day and contains 3 medications:
Breo Ellipta is also an inhaled medicine used for the once-daily treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults. However, Breo Ellipta only contains two medicines (also found in Trelegy):
Are the doses the same for Trelegy and Ellipta?
Do not use both Breo Ellipta and Trelegy Ellipta to treat your asthma or COPD. Only use one drug or the other as prescribed by your doctor. Follow your doctor’s instructions exactly.
Do not use other medicines that contain a long-acting beta-agonist (LABA) or an anticholinergic for any reason. Ask your health care provider or pharmacist if any of your other medicines contain LABA or anticholinergic medicines.
Neither of these drugs should be used as a fast-acting (rescue) inhaler for the relief of sudden breathing problems.
Neither Trelegy or Breo are approved for use in children.
Trelegy dosing
Breo dosing
After inhalation of either Trelegy or Breo, you should rinse your mouth with water (without swallowing) to lower the risk of developing oral thrush, a type of fungal infection.
Which is better - Trelegy or Breo ?
Both drugs have been shown to be effective for the treatment of asthma or COPD in controlled clinical studies. However, some patients may need to move up to triple therapy for long-term control of their breathing symptoms or flare-ups. In the past, this often involved the use of two separate inhalers.
Trelegy and Breo studies
COPD Trelegy Ellipta and Breo Ellipta were both compared in a study evaluating over 10,000 patients being treated for COPD. In this study, called the IMPACT study, the main endpoint researchers were looking at was the annual rate of moderate to severe exacerbations ("flare-ups") in patients with COPD.
Asthma In the CAPTAIN study in over 2,400 patients with asthma, Trelegy Ellipta led to an improvement in lung function when compared to Breo using two different strengths of Trelegy: 100/62.5/25 mcg and 200/ 62.5/25 mcg.
Your results can vary as each person’s condition is unique. Your doctor can evaluate your symptoms and determine which treatment may be the best option for you.
Can I use Trelegy or Breo for sudden breathing problems?
No. Neither drug is a rescue medicine for bronchospasm attacks and sudden breathing problems. Use only your fast-acting inhalation medicine (for example, albuterol or levalbuterol) for sudden symptoms.
If you do not have a fast-acting inhaler, call your doctor for a prescription. Seek emergency medical treatment or call 911 if your breathing problems get worse quickly.
Do not take Trelegy or Breo with other medicines that contain a long-acting beta2-adrenergic agonist (LABA) or an anticholinergic for any reason.
Are side effects similar between Trelegy and Breo?
Trelegy contains fluticasone, vilanterol and umeclidinium, while Breo contains only fluticasone and vilanterol. Because Trelegy contains an extra medicine, some side effects may differ between the two drugs.
Examples of similar side effects seen with the use of Trelegy Ellipta or Breo Ellipta include:
Additional common side effects you may experience with Trelegy that were not reported with Breo include:
Additional common side effects you may experience with Breo that were not reported with Trelegy include:
These are not all of the common or serious side effects that can occur with Trelegy Ellipta or Breo Ellipta. See their individual package inserts to review more side effects (in detail), or ask your doctor or pharmacist.
How do Trelegy and Breo come from the pharmacy?
Both Trelegy Ellipta and Breo Ellipta come as dry powder oral inhalers that you use once a day. You breathe the medicine into your lungs. Your doctor, nurse or pharmacist can show you how to use your inhaler. Do not use both of these medicines to treat your asthma or COPD.
These inhalers come with foil strips that contain the medicine. You place the foil strips into the inhaler before you breathe in the medicine.
Which costs more - Trelegy or Breo?
The cost of medications can vary based on your insurance type, coverage, copays, pharmacy and location.
These are expensive medications. If your insurance does not cover these medications, you may be able to receive help for your prescription costs from GlaxoSmithKline (GSK), the manufacturer of these medicines.
In addition, online coupons and discount cards are available that may lower your price if you are paying cash.
If you are still having trouble with the cost of this medicine, contact your doctor to determine if there are other, more affordable options available to treat your asthma or COPD.
Bottom Line
This is not all the information you need to know about Trelegy Ellipta or Breo Ellipta for safe and effective use. Review the full product information and discuss this information with your doctor or other health care provider.
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Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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