What happens when you stop taking Ozempic?
If you stop using Ozempic injection for type 2 diabetes or weight loss, much of the weight you have lost will most likely return within a few months to one year after you stop treatment, your blood sugar levels will rise and you may lose any positive benefit for heart health.
Contact your doctor before you stop Ozempic. Type 2 diabetes, obesity or being overweight are chronic (long-term) health conditions. Your healthcare provider may recommend that you transition to another treatment, reduce your dose to help with possible side effects, and maintain your exercise and diet plan to help control weight gain.
If you are having trouble accessing Ozempic due to a drug shortage or cost concerns, your healthcare provider can recommend alternatives or money-saving options. Novo Nordisk, the manufacturer, may be able to offer copay assistance or patient financial assistance, if you qualify.
What happens to your body if you stop Ozempic?
When you stop using Ozempic, all of the drug mechanisms at work to help with blood sugar control and weight loss will stop. Your health problems, like type 2 diabetes or heart disease may worsen and your risk for serious events (like a heart attack or stroke) may increase.
When you stop Ozempic, your full appetite may return within a week, increasing your calorie intake and leading to weight regain. In addition, your blood sugar levels may spike, worsening the effects of type 2 diabetes on your blood vessels, which can lead to eye, heart and nerve disease.
Any common, non-serious side effects you may be experiencing should also stop, for example, stomach side effects (diarrhea, nausea or stomach pain) or injection site reactions.
Studies on stopping semaglutide treatment
STEP 1 trial extension study for semaglutide
The STEP 1 trial extension study looked at weight regain and other effects on the body after stopping treatment with semaglutide. Other studies have shown that stopping weight management treatments usually lead to a regain of the lost weight.
Initially 1961 adults with overweight or obesity received treatment for 68 weeks with semaglutide 2.4 mg (the usual weight loss dose) or a placebo (an inactive agent), in addition to diet and exercise counseling.
After 68 weeks, 327 of the original 1961 participants stopped treatment and counseling for up to 120 weeks. Investigators wanted to see how stopping treatment for 52 weeks changed weight and effects on the body, like blood sugar levels (HbA1c), blood pressure, cholesterol (lipid) levels and markers of inflammation (called C-reactive protein), which may indicate a risk of heart disease.
Of the 327 participants in the original 68 weeks study, those who had received semaglutide had lost on average 17.3% of their body weight compared to 2% of body weight in the placebo group.
Weight regain
Effects on the heart
Why people stop using Ozempic?
Side effects with Ozempic like nausea, vomiting, diarrhea, stomach pain or constipation are common and may be one reason why people stop Ozempic. In most people, these effects usually lessen over a few weeks with continued treatment and slower dose increases.
In studies, about one-third (over 30%) of patients receiving Ozempic experienced stomach side effects, compared to 15% taking a placebo (an inactive treatment). About 3% to 4% of people had to stop treatment due to stomach side effects.
Stomach side effects can get worse with higher doses, so your dose is usually slowly increased to help lessen these reactions.
If you and your doctor decide that you should stop treatment because of stomach side effects, these side effects will usually lessen or go away over about one week to one month.
If you restart Ozempic, your doctor will slowly increase your dose to help avoid stomach side effects. Higher doses of Ozempic at the beginning of treatment may worsen stomach side effects.
5 tips to prevent weight gain after stopping Ozempic
Putting weight back on after stopping a weight loss treatment is common, so know that you are not alone. But there are a few things you can do to help prevent regaining all of your weight.
Finally, don’t beat yourself up. It’s hard to lose weight, we all know that. And putting weight back on, after initially losing it, can take a toll on your mental health. Keep your mood and strength up by staying active, eating healthfully, maintaining your social circles and talking to a trusted friend, family member or healthcare provider when needed.
This is not all the information you need to know about Ozempic (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
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